Navigation Links
Cisplatin-very Effective Than Carboplatin in Nonsmall Cell Lung Cancer Treatment

Some patients with advanced nonsmall-cell lung cancer (NSCLC) have slightly higher survival rates when treated with the chemotherapy drug cisplatin than another platinum-based drug carboplatin, according to a study in the June 6 Journal of the National Cancer Institute. The authors conclude that cisplatin chemotherapy should remain the standard of care for these patients.

Most clinicians in North America prefer carboplatin to cisplatin because it has fewer side effects and is easier to administer. Andrea Ardizzoni, M.D., of University Hospital in Parma, Italy, and colleagues conducted a review of nine randomized trials comparing the survival of 2,968 NSCLC patients who received either cisplatin- or carboplatin-based chemotherapy.

Patients who received cisplatin lived slightly longer than those treated with carboplatin, with a median survival of 9.1 months compared with 8.4 months. The difference in survival was not statistically significant, because both drugs had side effect. Carboplatin was more likely to decrease blood platelet levels, while cisplatin was more likely to cause nausea, vomiting, and damage to the kidneys.

Christopher and colleagues discuss the renewed rivalry between cisplatin and carboplatin, particularly in the face of new developments in adjuvant chemotherapy for NSCLC patients. The apparent superiority of cisplatin over carboplatin demonstrated in this paper should not be taken lightly, particularly in patients being treated with curative intent.

Equally inadvisable would be the use of cisplatin in patients with metastatic NSCLC for whom the drug may be poorly tolerated, such as those with significant baseline renal impairment, hearing loss, peripheral neuropathy, or other serious medical comorbidities, the authors wrote.


'"/>




Page: 1

Related medicine news :

1. New Way to "See" Genes, Evaluate Effectiveness of Gene Therapies Discovered
2. Inhaled Steroids Safe & Effective for Children with Asthma
3. ZD1839 Proves Effective - A Breakthrough in fighting Lung Cancer
4. Fluoride Found Effective in Osteoporosis
5. Aspirin and Warfarin Are Equally Effective for Stroke Prevention
6. Implantable Contact Lens Found Safe and Effective
7. Effective And Economical Agent For Anthrax
8. Stem Cell Transplants May Be Effective For MS Patients
9. Effective therapy for Huntingtons disease
10. Chemotherapy Effective for Bladder Cancer
11. Drug Effective for Vascular Dementia
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... ... March 23, 2017 , ... Altec ... The Resource Group as their 2016 Microsoft Dynamics Partner of the Year at ... CA. The award recognizes The Resource Group for their outstanding relationship with ...
(Date:3/23/2017)... ... 23, 2017 , ... Sharon Kleyne, host of the nationally syndicated radio program, ... VoiceAmerica, recently talked on her program about how she is looking forward to World ... of an important distinction. World Water Day, Kleyne pointed out, is an occasion for ...
(Date:3/23/2017)... ... March 23, 2017 , ... It’s that time of year ... are thinking about summer internships , which can be frustrating when they don’t ... at Garden Media Group, a boutique public relations firm outside of Philadelphia, have offered ...
(Date:3/23/2017)... Richey, FL (PRWEB) , ... March 23, 2017 , ... ... announce that 2017 marks the 40th Anniversary of ABQAURP’s dedication to Health Care Quality ... honors those who have contributed not only to the association, but also to the ...
(Date:3/23/2017)... ... 23, 2017 , ... On 2 March 2017, the United ... Operations Command’s Patriot Award. The award was presented by the USSOCOM Commander, General ... for its significant and enduring support to the command. , Accepting the ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... March 23, 2017  Cornerstone Pharmaceuticals, Inc., ... major milestone today.  Following successful End-of-Phase I ... Food and Drug Administration (FDA), the Company ... regulatory path forward to conduct pivotal trials ... with acute myeloid leukemia (AML) and pancreatic ...
(Date:3/23/2017)... 2017 BioLineRx Ltd. (NASDAQ/TASE: BLRX), a ... that it has acquired Agalimmune Ltd., a private UK-based company ... a $6 million upfront payment, of which $3 million is ... payments may be made based on development and commercial milestones. ... Agalimmune,s ...
(Date:3/23/2017)... , March 23, 2017 AbbVie, a global ... Award-winning choreographer Julianne Hough is helping to ... in the Know about ME in EndoMEtriosis . " ... inspiring women to learn about and understand endometriosis, a ... and to address their symptoms with a healthcare ...
Breaking Medicine Technology: