Navigation Links
Cigarette Smoke Alters DNA in Sperm, Genetic Damage Could Pass to Offspring

PHILDALPHIA -- The science has long been clear that smoking causes cancer, but new research shows that children could inherit genetic damage from a father who smokes .

Canadian researchers have demonstrated in mice that smoking can cause changes in the DNA sequence of sperm cells, alterations that could potentially be inherited by offspring. The results of their study are published in the June 1 issue of Cancer Research, a journal of the American Association for Cancer Research.

'Here we are looking at male germline mutations, which are mutations in the DNA of sperm. If inherited, these mutations persist as irreversible changes in the genetic composition of off-spring.' said Carole Yauk, Ph.D., lead author of the study and research scientist in the Mutagenesis Section of Health Canadas Environmental and Occupational Toxicology Division. 'We have known that mothers who smoke can harm their fetuses, and here we show evidence that fathers can potentially damage offspring long before they may even meet their future mate.'

Males, whether they are mouse or man, generate a constant supply of new sperm from self-renewing spermatogonial stem cells. Yauk, along with colleagues at Health Canada and McMaster University, studied the spermatogonial stem cells of mature mice that had been exposed to cigarette smoke for either six or 12 weeks to look for alterations in a specific stretch of repeated portions of DNA, called Ms6-hm, which does not contain any known genes. The 'smoking' mice were exposed to two cigarettes per day, the equivalent based on blood levels of tobacco by-products of an average human smoker, according to research previously published by one of the study's co-authors.

Yauk and her colleagues found that the rate of Ms6-hm mutations in the smoking mice were 1.4 times higher than that of non-smoking mice at six weeks, and 1.7 times that of non-smoking mice at 12 weeks. 'This suggests that damage is related
'"/>




Page: 1 2

Related medicine news :

1. Cancers of Colon & Rectum linked to Cigarette Smoking
2. Low-Tar Cigarettes As dangerous As High-Tar Cigarettes
3. Reducing Number Of Cigarettes Not Enough
4. The Harmful Effects Of Cigarette Smoke
5. Dangers Of Cigarette Smoke
6. Genes Linked To Cigarette Addiction
7. Light Cigarettes - Not So Light?
8. Cigarette Smoking Leads To Development Of Type 2 Diabetes In Patients With Coronary Artery Disease
9. Passive Cigarette Smoking Increases Isoprostane Formation
10. British company developing ‘Safer Cigarettes
11. Anti-smoking advertisements to be funded by Cigarette manufacturers
Post Your Comments:
(Date:1/22/2015)... Mass. (PRWEB) January 22, 2015 EBSCO ... (AMA) are expanding their relationship in an effort to ... around the world. While EBSCO has long made AMA journals ... a sales agent for The JAMA Network. , ...
(Date:1/22/2015)... a famous dress online store for wedding dresses and other ... of wedding dresses , and launches a site-wide women’s dress ... on your big day; the wedding gown is the most ... find the most suitable wedding dress. Now, we are proud ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Lower-Auto-Insurance.com has released a ... kit in a car for reducing the costs of an ... will also be able to get lower prices for their vehicle ... an important role in determining policy costs. Because of this, ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 State Forestry ... data management system with support from GEOSYSTEMS, a dedicated ... new solution will leverage Hexagon Geospatial’s ERDAS APOLLO ... data as well as point clouds and documents. This ...
(Date:12/26/2014)... said that nothing makes a lady feel more feminine than ... shows its new selection of navy cocktail dresses , ... navy cocktail gowns are the cornerstones of the site’s cocktail ... dresses in bright neon colors can be dressed up or ...
Breaking Medicine News(10 mins):Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2
... dengue fever that can sometime be deadly and this is ... ,Dengue fever is a benign acute febrile syndrome occurring in ... aegypti), transmitted viral disease. The virus causes Dengue shock syndrome ... as "serotypes") of dengue. , ,Infection and recovery from ...
... Stanford, CA -- Successful eradication of Helicobacter may not ... are left behind. This was reported by Research led ... of Medicine., ,The paper by Mueller et al., ... in the pathogenesis of Helicobacter-induced MALT lymphoma," appears in ...
... Wake Forest University School of Medicine had discovered a drug ... of sleep deprivation on the brain. The research results were ... of Science- Biology, and may go a long way in ... who work round the clock., ,The study’s results are ...
... research report, by researchers from National Institute of Child Health ... suggest that a drug used for reducing the risk of ... an alternative to conducting surgery after a miscarriage., ,The ... of Medicine. , ,The drug, misoprostol, has been used ...
... has entered the Guinness Book of Records after covering a ... in 28 hours. The 68-year-old Jan Klima's feat was announced ... Czech record database., ,The man from Trest, who ... walked to a regular check-up in Prague's Teaching Hospital. Klima ...
... processes between cells that could perhaps be extrapolated to prevent ... ,Normally cells have a blood supply to send nutrients from ... that don't have that, there has to be tiny bridge ... in the same way. This type of a communication network ...
Cached Medicine News:Health News:Dengue fever in Delhi after the Monsoon 2Health News:Dengue fever in Delhi after the Monsoon 3Health News:Dengue fever in Delhi after the Monsoon 4Health News:Helicobacter pylori Antibiotic Treatment of Peptic Ulcer May not Prevent Gastric lymphomas 2Health News:Treatment For Reversal Of Effects Of Sleep Deprivation In Brain 2Health News:Drugs As Alternative To Surgery After Miscarriage 2
(Date:1/23/2015)...  Now available for sale, The Armor1 Ankle Roll Guard is ... sprains by cushioning the ankle from an inversion or ... outside of any shoe type and allows the user ... protection against sprains. With customers in physical therapy, podiatry, ...
(Date:1/23/2015)... N.Y. , Jan. 23, 2015  Lixte Biotechnology Holdings, Inc. ... its Phase I trial of Lixte,s lead compound, LB‑100, is ... John S. Kovach , M.D., the founder ... planned to be completed at a single site. Accrual of ...
(Date:1/23/2015)... Africa , Jan. 23, 2015   Leatt Corporation ... personal protective equipment for all forms of sports, including ... Leatt-Brace® neck brace, announced today that the UISP Lega ... now requires all riders to wear a neck brace ...
Breaking Medicine Technology:The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 2Lixte Biotechnology Holdings Announces Expansion Of Clinical Sites For Its Phase I Trial Of Its Lead Anti-Cancer Compound, LB-100 3Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3
... 2010 /PRNewswire-Asia-FirstCall/ -- Lotus Pharmaceuticals, Inc. (OTC Bulletin Board: ... fast-growing, profitable developer, manufacturer and seller of medicine and ... today that the Company will effect a two-for-one reverse ... minimum share price requirements in connection with its application ...
... 31, 2010 CVS Caremark (NYSE: CVS ... to acquire the Medicare Part D business of Universal ... billion.  Universal American is a leading Medicare Prescription Drug Plan ... acquisition will more than double the size of CVS ...
Cached Medicine Technology:Lotus Pharmaceuticals Announces Approval of Reverse Stock Split 2CVS CAREMARK to Purchase Universal American's Medicare Part D Business 2CVS CAREMARK to Purchase Universal American's Medicare Part D Business 3CVS CAREMARK to Purchase Universal American's Medicare Part D Business 4
The Link SP II Hip stem for cemented revisions...
The proximally modular S-ROM Total Hip System provides custom capability at non-custom prices and is competitive with conventional porous coated systems....
Quatroloc Revision Hip System...
Severe revision options for the knee and hip...
Medicine Products: