Navigation Links
Chronic Metamphetamine Abuse is Related to Cardiovascular Disease

Until about six years ago, methamphetamine use was seen mostly in the western and rural United States. Today, methamphetamine abuse has expanded rapidly throughout the rest of the country and across different ethnic groups. In recent years, the spread of methamphetamine abuse across the United States has been as rapid as it has been alarming.

According to the 2005 National Survey on Drug Use and Health (NSDUH), an estimated 10.4 million Americans ages 12 or older have used methamphetamine at least once in their lifetimes for non-medical reasons.

The study showed that long-term methamphetamine use changes endogenous proteins in drug users, causing aberrant immune responses. As a result, increased levels of proinflammatory cytokines-proteins involved in immune response-may be a previously unrecognized molecular mechanism for the development of cardiovascular disorders such as vasculitus, an inflammation of the blood vessels.

Our previous studies showed that methamphetamine can glycate or add sugars to proteins, said Scripps Research Professor Kim Janda, who conducted this study in collaboration with Scripps Research Assistant Professor Tobin Dickerson and other colleagues. In this study, we found that the immune system responds dramatically to this methamphetamine-induced glycation, which may lead to vascular inflammation and deterioration if left untreated. These problems are the direct result of long-term methamphetamine abuse.

Previous studies may have missed the impact of chronic methamphetamine use on the vascular periphery, Janda said, because they focused on the response of the microglia-the immune cells of the central nervous system-and the appearance of methamphetamine-related neurotoxicity in the central nervous system.

The study found that there was a direct relationship between methamphetamine intake and the level of circulating antibodies in animal models. This immune response, cou
'"/>




Page: 1 2

Related medicine news :

1. Roller coasters – cause “Chronic Headache?
2. In Chronic Diseases - Poor compliance of Patients with drug treatment
3. New Treatment for Chronic Eczema
4. Novel Therapy for Chronic Problem
5. Overcoming Chronic Fatigue
6. Chronic Fatigue, Pain Linked to Sinusitis
7. Chronic Diseases said to Cause Falls in the Elderly
8. Epilepsy Drug May Relieve Chronic Headaches
9. Women Worse Affected By Chronic Cough
10. A Drug That Might Relieve Chronic Cough
11. A Sedentary Childhood Could Lead To Chronic Fatigue Latter In Life
Post Your Comments:
(Date:7/12/2014)... The Passenger Information System market is estimated ... million by 2019, at an expected CAGR of 26.5% ... public transport infrastructure in North America is well developed ... every corner of the region. The growing ridership figures ... service providers are driving the North American Passenger Information ...
(Date:7/12/2014)... HealthDay Reporter SATURDAY, July 12, 2014 ... surgical technique used to grind up uterine growths and remove ... cancer to other parts of a woman,s body, U.S. health ... and Drug Administration also said that women who do undergo ... a written consent stating that they understand the potential risks, ...
(Date:7/12/2014)... July 12, 2014 The Security Analytics ... 2013 to $3,376.6 million by 2019, at an expected ... 2019. The challenges to counter the increasing number of ... of outdated cyber defense systems in organizations are enormous. ... and remodeling their existing architecture to develop better and ...
(Date:7/12/2014)... (HealthDay News) -- If you make exercise fun, you,ll eat ... experiment, 56 adults were led on a 1.4-mile walk and ... a scenic walk. The participants were given lunch after the ... outing ate 35 percent more chocolate pudding for dessert than ... In another experiment, 46 adults were given mid-afternoon snacks after ...
(Date:7/12/2014)... “After my mom’s stroke, she loss the use of her right ... of his left side. Eating became a difficult task for them ... them enjoy eating again,” said an inventor, from Fayetteville, N.C. As ... PLATE (P C H PLATE). , The PATRICIA CAROL HALL PLATE ... for individuals who suffer from stroke, experience tremors or loss of ...
Breaking Medicine News(10 mins):Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 4Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 2Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 3Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 4Health News:Make Exercise Fun, Eat Less Afterwards 2
... COLUMBIA, Mo. Most people have witnessed otherwise intelligent ... intoxicated, but what specifically happens in the brain to ... effects on brain activity from the University of Missouri ... people when they are making a mistake, ultimately reducing ...
... September 1, 2011Scientists involved in DNA vaccine research are ... effective delivery systems and the development of more efficient ... Top investigators in the field recently discussed these and ... "DNA Vaccines: Building on Clinical Progress and Exploring New ...
... THURSDAY, Sept. 1 (HealthDay News) -- Most children need to get ... last year, the American Academy of Pediatrics says. The 2011-12 ... year,s vaccine, but a person,s immunity decreases by as much as ... it,s important for children to get another flu shot this year, ...
... --,Molecular signals from stem cells within the skin,s fatty layer ... to new treatments for baldness in people, researchers report. ... to talk to the dormant stem cells at the base ... hair to grow again," senior study author Valerie Horsley, an ...
... engineer? Sex hormones strongly influence people,s interests, which ... to psychologists. , "Our results provide strong support ... by working with things versus people," said Adriene ... Sheri A. Berenbaum, professor of psychology and pediatrics, ...
... THURSDAY, Sept. 1 (HealthDay News) -- The intensity of exercise, ... your chances of living a longer life, a new study ... that men with high levels of cycling intensity lived 5.3 ... longer, than men with low intensity. Among female cyclists, ...
Cached Medicine News:Health News:Alcohol dulls brain 'alarm' that monitors mistakes, MU study finds 2Health News:GEN reports on advances in DNA vaccine delivery and production 2Health News:Last Year's Flu Shot Won't Protect Kids This Season 2Health News:Mouse Study Could Give New Clues to Fighting Baldness 2Health News:Sex hormones impact career choices 2
(Date:7/10/2014)... 2014  Decision Resources Group finds that while ... specialists are willing to prescribe Durata,s Dalvance (dalbavancin) ... as OPAT, approximately two-thirds of the respondents reported ... hospital inpatients. However, our findings indicate that nearly ... on OPAT following hospital discharge, and most are ...
(Date:7/10/2014)... 2014 Decision Resources Group finds that over ... Food and Drug Administration,s (FDA) approval of Vifor Fresenius ... was approved by the FDA in November 2013 for ... patients on dialysis. Other key findings from ... 2014 : , ...
(Date:1/15/2014)... Jan. 15, 2014 Most osteoporosis patients want a ... recent online survey* sponsored by Mission Pharmacal Company. The ... Osteoporosis Foundation online support community, revealed that 74 percent ... comes in a form other than a pill or ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3
... 12, 2011 Although medical devices possess strong ... medical device companies to invest more resources in ... products.   Tactical marketers in medical ... as troubleshooting post-launch and managing product enhancements, but ...
... Aug. 12, 2011 PLC Systems Inc. (OTCBB: PLCSF), ... reported financial results for the three- and six month ... the company,s RenalGuard® operations, since PLC completed the sale ... during the first quarter of 2011. Results from the ...
Cached Medicine Technology:Medical Device Marketing Groups Focus More Resources on Tactical Activities When Compared to Pharmaceutical Counterparts 2PLC Systems Reports Second Quarter 2011 Results 2PLC Systems Reports Second Quarter 2011 Results 3PLC Systems Reports Second Quarter 2011 Results 4PLC Systems Reports Second Quarter 2011 Results 5PLC Systems Reports Second Quarter 2011 Results 6
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: