Navigation Links
Chronic Metamphetamine Abuse is Related to Cardiovascular Disease

Until about six years ago, methamphetamine use was seen mostly in the western and rural United States. Today, methamphetamine abuse has expanded rapidly throughout the rest of the country and across different ethnic groups. In recent years, the spread of methamphetamine abuse across the United States has been as rapid as it has been alarming.

According to the 2005 National Survey on Drug Use and Health (NSDUH), an estimated 10.4 million Americans ages 12 or older have used methamphetamine at least once in their lifetimes for non-medical reasons.

The study showed that long-term methamphetamine use changes endogenous proteins in drug users, causing aberrant immune responses. As a result, increased levels of proinflammatory cytokines-proteins involved in immune response-may be a previously unrecognized molecular mechanism for the development of cardiovascular disorders such as vasculitus, an inflammation of the blood vessels.

Our previous studies showed that methamphetamine can glycate or add sugars to proteins, said Scripps Research Professor Kim Janda, who conducted this study in collaboration with Scripps Research Assistant Professor Tobin Dickerson and other colleagues. In this study, we found that the immune system responds dramatically to this methamphetamine-induced glycation, which may lead to vascular inflammation and deterioration if left untreated. These problems are the direct result of long-term methamphetamine abuse.

Previous studies may have missed the impact of chronic methamphetamine use on the vascular periphery, Janda said, because they focused on the response of the microglia-the immune cells of the central nervous system-and the appearance of methamphetamine-related neurotoxicity in the central nervous system.

The study found that there was a direct relationship between methamphetamine intake and the level of circulating antibodies in animal models. This immune response, cou pled with antibodies binding to methamphetamine, might make the drug less biologically available leading to an increased need for higher and higher doses, a problem found among chronic methamphetamine users.

The resulting glycated proteins-called advanced glycation endproducts (AGEs)-are associated with a number of diseases including diabetes and Alzheimers disease. Long-lived AGEs can easily modify protein function, initiate adverse cellular reactions, and form damaging deposits on arterial walls.

Methamphetamine-AGE proteins not only increased antibody production, the study said, but were strong enough to overcome the drugs natural immunosuppressive qualities. In addition, a wide range of cytokines directly linked to AGE exposure were increased in rats that self-administered methamphetamine.

The study also showed that even limited daily access to the drug was enough to produce an over-expression of vascular endothelial growth factor (VEGF), a potent signaling cytokine involved in angiogenesis and vasodilation. Our data suggest that even methamphetamine use at lower doses may be enough to increase VEGF to potentially detrimental levels, Janda said.

In addition to Janda and Dickerson, both of Scripps Researchs Skaggs Institute for Chemical Biology and Worm Institute for Research and Medicine, authors of the study, Self-Vaccination by Methamphetamine Glycation Products Chemically Links Chronic Drug Abuse and Cardiovascular Disease, include Scripps Research investigators Jennifer Treweek, George F. Koob, and Sunmee Wee.


Related medicine news :

1. Roller coasters – cause “Chronic Headache?
2. In Chronic Diseases - Poor compliance of Patients with drug treatment
3. New Treatment for Chronic Eczema
4. Novel Therapy for Chronic Problem
5. Overcoming Chronic Fatigue
6. Chronic Fatigue, Pain Linked to Sinusitis
7. Chronic Diseases said to Cause Falls in the Elderly
8. Epilepsy Drug May Relieve Chronic Headaches
9. Women Worse Affected By Chronic Cough
10. A Drug That Might Relieve Chronic Cough
11. A Sedentary Childhood Could Lead To Chronic Fatigue Latter In Life
Post Your Comments:

(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, revealed ... 1-1 ). More than 3.7 billion people under the age of 50 – or ... to WHO's first global estimates of HSV-1 infection . , "The data shocks us ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... Microsoft Dynamics SL User Group (MSDSLUG). Recognized as Microsoft’s official group for end ... Microsoft Dynamics SL software users, partners, industry experts and representatives. Intellitec Solutions’ membership ...
(Date:11/27/2015)... ... November 27, 2015 , ... The ... prided itself for not only fulfilling the needs of advisers and clients but ... affordable price and providing top-tier customer service. However, there's always room for improvement, ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... CBD ... Accreditation of Allied Health Education Programs (CAAHEP) awarded accreditation to its Diagnostic Medical Sonography ... CAAHEP accredited colleges, as only one of twelve colleges and universities in the state ...
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... ... California Medical Associates, Inc. and Dr. Tucker Bierbaum with Emergency Medicine at ... They observed that both STEMI and Sepsis conditions present in similar ways and require ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... November 26, 2015 ... the "2016 Future Horizons and Growth ... Testing Market: Supplier Shares, Country Segment Forecasts, ... their offering. --> ) ... "2016 Future Horizons and Growth Strategies in ...
(Date:11/26/2015)... 2015 Research and Markets ( ) ... Care Market by Type (Dressings, Therapy Devices, Active Wound ... Out-Patient Facility), and Geography - Global Forecast to 2020" ... --> --> The purpose of this ... of the global advanced wound care market. It involves ...
(Date:11/26/2015)... , Nov. 26, 2015 Research and ... of the "2016 Future Horizons and Growth ... Market: Supplier Shares, Country Segment Forecasts, Competitive Intelligence, ... --> --> ... of the Italian therapeutic drug monitoring market, including ...
Breaking Medicine Technology: