Navigation Links
Chromosome Ends Trigger DNA Damage Response For Telomere Protection,,,,

Researchers from the Salk Institute for Biological Studies have suggested that a localized DNA damage response at telomeres after replication is essential for recruiting the //processing machinery that promotes formation of a chromosome end protection complex.

Telomeres, the ends of linear chromosomes, represent a problem for the control of genome stability and the DNA damage machinery. An exposed telomere could readily be taken for a break and recognized as damage, and thus, have to be distinguished from DNA breaks that initiate a DNA damage response.

To prevent the cell's DNA repair machinery from confusing telomeres with broken strands of DNA that need to be repaired, the tips of chromosomes are tucked in and shielded by a phalanx of proteins, forming a protective "cap".

The research team, led by Jan Karlseder, found that several well-known members of the DNA damage response machinery, recruited by the unprotected telomeres, congregate at the tips of chromosomes.

The authors believe that the localization of repair proteins to chromosome ends, and detection of telomeres as damage at this precise time are necessary to trigger the re-formation of a protective telomeric structure.

In contrast to damaged strands of DNA, they hypothesize, the repair process never gets fully underway at telomeres. Instead, the very tips of the chromosomes are looped back, tucked in and covered with telomeric proteins.

The cell tries to fix everything to make sure that the genetic information is safe and complete for the next generation of cells, but in the case of healthy chromosome tips or telomeres, repair would have disastrous consequences.

Repairing telomeres would randomly fuse whole chromosomes end-to-end. During the next cell division the sorting mechanism, which ensures that each daughter cell receives a full complement of chromosomes would inevitably rip the fused chromosomes apart.

The researchers assert that fusion breakage cycles scramble the genome over time, and cause genome instability, which is a hallmark of cancer cells, and this demonstrates the importance of telomeres in preserving genome integrity and preventing cancer development.


'"/>




Related medicine news :

1. Chromosomes to predict oral cancer
2. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
3. Occupational Exposure To Radiation Causes Chromosome Aberrations
4. Chromosome 6 has the Dyslexia Gene
5. Missing Chromosomes Revealed Brain Tumor Therapy Effect – Research Find
6. Cell Survival Depends on Chromosome Integrity
7. Using Multiphoton Microscopy to See Chromosomes in Action
8. Nicotine Dependence Gene Mapped to Chromosome 5
9. Food May Trigger Life-Threatening Asthma
10. Common Plant Triggers Asthma
11. Stress can Trigger Heart Problems
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... Creek, Michigan (PRWEB) , ... June 26, 2016 , ... ... joined as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in ... in honor of the city’s history as home to some of the world’s leading ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned ... developed to enhance the health of felines. The formula is all-natural and is made ... in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root ...
(Date:6/26/2016)... , ... June 26, 2016 , ... ... once they have been diagnosed with endometriosis. These women need a treatment plan ... require a comprehensive approach that can help for preservation of fertility and ultimately ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... 2022" report to their offering. ... with kidney failure, it replaces the function of kidneys by ... and thus the treatment helps to keep the patient body,s ... Increasing number of ESRD patients & substantial healthcare ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that it ... (procalcitonin) assay as a dedicated testing solution for people ... Roche is the first IVD company in the U.S ... assessment and management. PCT is a sepsis-specific ... blood can aid clinicians in assessing the risk of ...
Breaking Medicine Technology: