Navigation Links
Chromosome Ends Trigger DNA Damage Response For Telomere Protection,,,,

Researchers from the Salk Institute for Biological Studies have suggested that a localized DNA damage response at telomeres after replication is essential for recruiting the //processing machinery that promotes formation of a chromosome end protection complex.

Telomeres, the ends of linear chromosomes, represent a problem for the control of genome stability and the DNA damage machinery. An exposed telomere could readily be taken for a break and recognized as damage, and thus, have to be distinguished from DNA breaks that initiate a DNA damage response.

To prevent the cell's DNA repair machinery from confusing telomeres with broken strands of DNA that need to be repaired, the tips of chromosomes are tucked in and shielded by a phalanx of proteins, forming a protective "cap".

The research team, led by Jan Karlseder, found that several well-known members of the DNA damage response machinery, recruited by the unprotected telomeres, congregate at the tips of chromosomes.

The authors believe that the localization of repair proteins to chromosome ends, and detection of telomeres as damage at this precise time are necessary to trigger the re-formation of a protective telomeric structure.

In contrast to damaged strands of DNA, they hypothesize, the repair process never gets fully underway at telomeres. Instead, the very tips of the chromosomes are looped back, tucked in and covered with telomeric proteins.

The cell tries to fix everything to make sure that the genetic information is safe and complete for the next generation of cells, but in the case of healthy chromosome tips or telomeres, repair would have disastrous consequences.

Repairing telomeres would randomly fuse whole chromosomes end-to-end. During the next cell division the sorting mechanism, which ensures that each daughter cell receives a full complement of chromosomes would inevitably rip the fused chromosomes apart.

The researchers assert that fusion breakage cycles scramble the genome over time, and cause genome instability, which is a hallmark of cancer cells, and this demonstrates the importance of telomeres in preserving genome integrity and preventing cancer development.


'"/>




Related medicine news :

1. Chromosomes to predict oral cancer
2. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
3. Occupational Exposure To Radiation Causes Chromosome Aberrations
4. Chromosome 6 has the Dyslexia Gene
5. Missing Chromosomes Revealed Brain Tumor Therapy Effect – Research Find
6. Cell Survival Depends on Chromosome Integrity
7. Using Multiphoton Microscopy to See Chromosomes in Action
8. Nicotine Dependence Gene Mapped to Chromosome 5
9. Food May Trigger Life-Threatening Asthma
10. Common Plant Triggers Asthma
11. Stress can Trigger Heart Problems
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2016)... Louis, Missouri (PRWEB) , ... February 10, 2016 ... ... 2016, in San Diego, will bring together more than 200 of the country’s ... healthcare for the future. , “The true benefit of the Forum is the ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... Armune ... Apifiny® across their network of laboratory service centers across the country. Launched in ... aid clinicians in the detection of prostate cancer. Apifiny order volume exceeded 3,000 tests ...
(Date:2/10/2016)... Burnsville MN (PRWEB) , ... February 10, 2016 ... ... announced that it will attend the Ohio Safety Congress and Expo event March ... held at the Greater Columbus Convention Center. , As the longest running ...
(Date:2/10/2016)... , ... February 10, 2016 ... ... – 1 UNF Drive, Jacksonville, FL 32224, February 26th: Amateur & Professional ... Elite Division - Time: 7:00pm – 10:00pm | Ticket Prices $30, Social ...
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... Anxiety of ... since the start of Medicare Part D a decade ago, according to The ... from older adults on how they are coping with rapidly rising costs. “The ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... 9, 2016 The leader in accelerated orthodontics, ... is the recipient of the 2015 Townie Choice ... Class II medical device that speeds up orthodontic tooth ... pain often associated with treatment, AcceleDent was selected by ... annual Orthotown survey of the most reliable ...
(Date:2/9/2016)... The life of Dr. Jan Vilcek , celebrated immunologist ...  Twists of fate, combined with sheer grit, brought him from ... communist Czechoslovakia to New York City ... history by playing a key role in the development of ...  Dr. Vilcek brings readers along his improbable journey in his ...
(Date:2/9/2016)... The new report "Global Anti-Bacterial Drugs Market Assessment & Forecast: 2015 ... that the North America continued to lead ... that translated into revenues worth US$ 16,907.3 million. ... Asia-Pacific , Latin America , ... global anti-bacterial market is inclined towards North America ...
Breaking Medicine Technology: