Navigation Links
Chromosome 6 has the Dyslexia Gene

Researchers at Yale University have discovered the 'DCDC2' gene associated with dyslexia. Dyslexia causes learning disabilities and affects millions of children around the world. //

The gene called 'DCDC2' gene is located on human chromosome 6 according to the researchers. The researchers found that a genetic alteration in DCDC2 causes disruption in the formation of brain circuits and this genetic alteration is transmitted within families.

"These promising results now have the potential to lead to improved diagnostic methods to identify dyslexia and deepens understanding of how the reading process works on a molecular level," said Jeffrey R. Gruen, M.D. from Department of Pediatrics at Yale School of Medicine.

"We now have strong statistical evidence that a large number of dyslexic cases--perhaps as many as 20 percent--are due to the DCDC2 gene," said Gruen. "The genetic alteration on this chromosome is a large deletion of a regulatory region. The gene itself is expressed in reading centers of the brain where it modulates migration of neurons. This very architecture of the brain circuitry is necessary for normal reading" he further added.

Gruen and co-authors compared specific DNA markers in 153 dyslexic families. For normal reading abilities the brain circuits communicate with each other. However when these circuits are disrupted thee is reading disability that presents as dyslexia. Although compensatory brain circuits are formed to compensate but these are ineffective in most of the children.

"We now have strong statistical evidence that a large number of dyslexic cases--perhaps as many as 20 percent--are due to the DCDC2 gene," said Gruen. "The genetic alteration on this chromosome is a large deletion of a regulatory region. The gene itself is expressed in reading centers of the brain where it modulates migration of neurons. This very architecture of the brain circuitry is necessary for normal reading."

The gene identification will provide a new tool for early diagnosis of dyslexia and more effective educational programs to address the unique needs and special talents of people with dyslexia.

Other authors on the study were Shelley D. Smith, Karl Hager, Matthew Held, Jonathan Liu, Richard K. Olson, Bruce F. Pennington, John C. DeFries, Joel Gelernter, Thomas O'Reilly-Pol, Stefan Somlo, Pawel Skudlarski, Sally E. Shaywitz, Bennett A. Shaywitz, Karen Marchione, Yu Wang, Murugan Parmasivam, Joseph J. LoTurco and Grier P. Page. The study to be published in a special issue of Proceedings of the National Academy of Sciences on October 28

Contact: Karen N. Peart karen.peart@yale.edu 203-432-1326 Yale University
'"/>




Related medicine news :

1. Chromosomes to predict oral cancer
2. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
3. Occupational Exposure To Radiation Causes Chromosome Aberrations
4. Chromosome Ends Trigger DNA Damage Response For Telomere Protection
5. Missing Chromosomes Revealed Brain Tumor Therapy Effect – Research Find
6. Cell Survival Depends on Chromosome Integrity
7. Using Multiphoton Microscopy to See Chromosomes in Action
8. Nicotine Dependence Gene Mapped to Chromosome 5
9. Dyslexia due to cerebellum abnormality
10. Dyslexia may slow a drivers reaction time as much as moderate drinking!!
11. Dyslexia Gene Identified and Called "KIAA0319"
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2017)... , ... January 23, 2017 , ... ... Assisted Living (IHCA/INCAL), will serve as a healthcare industry expert at the 2017 ... panel discussion, moderated by Inside Indiana Business host Gerry Dick, will feature an ...
(Date:1/23/2017)... ... 2017 , ... "ProRandom is a set of camera tools that allow video editors to integrate ... Pro X," said Christina Austin - CEO of Pixel Film Studios. , With ProRandom, ... video footage. ProRandom works by using a virtual camera to create the illusion of ...
(Date:1/23/2017)... ... ... a story of love and redemption, hope and uncertainty as a girl makes her ... Inn at the Mill” is the creation of published author, Lois Kulp, who was born ... Berks County on Crow Hill. The inn, the mill and "Post Yokel" are ...
(Date:1/23/2017)... ... , ... “Some Infallible Characteristics of Christ”: a fascinating and entrancing novel ... the creation of published author, Rev. Dr. Robert W. Thomas, the third of seven ... for over nineteen, a pastor for over fifteen years. He is a graduate of ...
(Date:1/22/2017)... ... January 22, 2017 , ... "Photo Cloud allows FCPX users to add favorited ... with complete ease," said Christina Austin - CEO of Pixel Film Studios. , ... FCPX timeline. Presets include scenes with one, three, four or five focus points. ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... SAN DIEGO and PALMA, ... Laboratoris Sanifit S.L., a clinical-stage biopharmaceutical ... announced that the first patient has been enrolled ... of lead candidate, SNF472, for the treatment of ... haemodialysis (HD). Most ESRD patients, in ...
(Date:1/23/2017)... Jan. 23, 2017 Just two weeks remain until legal experts ... gather in Central London to discuss the flow ... in the market, Parallel Trade 2017 . In the ... of attendees which is available to read in the event download ... Some of ...
(Date:1/21/2017)... ResMed (NYSE: RMD ), BMC ( ... Florida ) today announced they have agreed on a global ... be permitted to sell their existing products in exchange for royalty ... to 3B to close the Florida litigation ... of liability or wrongdoing by any party. The ...
Breaking Medicine Technology: