Navigation Links
Chromosome 6 has the Dyslexia Gene

Researchers at Yale University have discovered the 'DCDC2' gene associated with dyslexia. Dyslexia causes learning disabilities and affects millions of children around the world. //

The gene called 'DCDC2' gene is located on human chromosome 6 according to the researchers. The researchers found that a genetic alteration in DCDC2 causes disruption in the formation of brain circuits and this genetic alteration is transmitted within families.

"These promising results now have the potential to lead to improved diagnostic methods to identify dyslexia and deepens understanding of how the reading process works on a molecular level," said Jeffrey R. Gruen, M.D. from Department of Pediatrics at Yale School of Medicine.

"We now have strong statistical evidence that a large number of dyslexic cases--perhaps as many as 20 percent--are due to the DCDC2 gene," said Gruen. "The genetic alteration on this chromosome is a large deletion of a regulatory region. The gene itself is expressed in reading centers of the brain where it modulates migration of neurons. This very architecture of the brain circuitry is necessary for normal reading" he further added.

Gruen and co-authors compared specific DNA markers in 153 dyslexic families. For normal reading abilities the brain circuits communicate with each other. However when these circuits are disrupted thee is reading disability that presents as dyslexia. Although compensatory brain circuits are formed to compensate but these are ineffective in most of the children.

"We now have strong statistical evidence that a large number of dyslexic cases--perhaps as many as 20 percent--are due to the DCDC2 gene," said Gruen. "The genetic alteration on this chromosome is a large deletion of a regulatory region. The gene itself is expressed in reading centers of the brain where it modulates migration of neurons. This very architecture of the brain circuitry is necessary for normal reading."

The gene identification will provide a new tool for early diagnosis of dyslexia and more effective educational programs to address the unique needs and special talents of people with dyslexia.

Other authors on the study were Shelley D. Smith, Karl Hager, Matthew Held, Jonathan Liu, Richard K. Olson, Bruce F. Pennington, John C. DeFries, Joel Gelernter, Thomas O'Reilly-Pol, Stefan Somlo, Pawel Skudlarski, Sally E. Shaywitz, Bennett A. Shaywitz, Karen Marchione, Yu Wang, Murugan Parmasivam, Joseph J. LoTurco and Grier P. Page. The study to be published in a special issue of Proceedings of the National Academy of Sciences on October 28

Contact: Karen N. Peart karen.peart@yale.edu 203-432-1326 Yale University
'"/>




Related medicine news :

1. Chromosomes to predict oral cancer
2. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
3. Occupational Exposure To Radiation Causes Chromosome Aberrations
4. Chromosome Ends Trigger DNA Damage Response For Telomere Protection
5. Missing Chromosomes Revealed Brain Tumor Therapy Effect – Research Find
6. Cell Survival Depends on Chromosome Integrity
7. Using Multiphoton Microscopy to See Chromosomes in Action
8. Nicotine Dependence Gene Mapped to Chromosome 5
9. Dyslexia due to cerebellum abnormality
10. Dyslexia may slow a drivers reaction time as much as moderate drinking!!
11. Dyslexia Gene Identified and Called "KIAA0319"
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... ... 05, 2016 , ... Freed-Hardeman University President Joe A. Wiley ... joint enrollment and degree completion agreement. The agreement, which begins with the ... FHU|Dickson. , The agreement allows students to be jointly admitted to both ...
(Date:2/5/2016)... ... February 05, 2016 , ... The American public tends to feel ... be safer than regular municipal or well water. The recent experience with lead contaminated ... could go a long way toward increasing public acceptance of recycled waste water as ...
(Date:2/5/2016)... York, New York (PRWEB) , ... February 05, 2016 , ... ... announced the election of Patrick McDermott as Chairman of the National Board of Directors. ... Pat as Chairman of the Board,” stated Leslie A. Chambers , APDA President ...
(Date:2/5/2016)... ... February 05, 2016 , ... In sleep, when the defenses of the ... hallmark feature of patients with eating disorders is significant self-criticism, and consequently these patients ... obsessions are regarded as maladaptive means for coping with this unease, but also leads ...
(Date:2/5/2016)... Boston, MA (PRWEB) , ... February 05, 2016 ... ... hosted its inaugural Columbia University Men’s Soccer Career Development event in New York ... KICVentures, and Rocco Commisso, Chairman and CEO of Mediacom, (both alumnus of the ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016 ... addition of the "Global Obstetrics Partnering ... company profile to their offering. --> ... of the "Global Obstetrics Partnering 2010-2016: ... profile to their offering. --> ...
(Date:2/4/2016)...   Bernstein Liebhard LLP today announced that a ... District Court for the District of Arizona ... all persons or entities who purchased common shares of Insys ... from March 3, 2015 through January 25, 2016 (the "Class ... with violations of the Securities Exchange Act of 1934.  ...
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... and competitive market to drive long-term market growth ... very common set of chronic disorders that affect ... disparate in terms of their symptoms and key ... by dysregulation of immune pathways and an inappropriate ...
Breaking Medicine Technology: