Navigation Links
Chromosome 6 has the Dyslexia Gene

Researchers at Yale University have discovered the 'DCDC2' gene associated with dyslexia. Dyslexia causes learning disabilities and affects millions of children around the world. //

The gene called 'DCDC2' gene is located on human chromosome 6 according to the researchers. The researchers found that a genetic alteration in DCDC2 causes disruption in the formation of brain circuits and this genetic alteration is transmitted within families.

"These promising results now have the potential to lead to improved diagnostic methods to identify dyslexia and deepens understanding of how the reading process works on a molecular level," said Jeffrey R. Gruen, M.D. from Department of Pediatrics at Yale School of Medicine.

"We now have strong statistical evidence that a large number of dyslexic cases--perhaps as many as 20 percent--are due to the DCDC2 gene," said Gruen. "The genetic alteration on this chromosome is a large deletion of a regulatory region. The gene itself is expressed in reading centers of the brain where it modulates migration of neurons. This very architecture of the brain circuitry is necessary for normal reading" he further added.

Gruen and co-authors compared specific DNA markers in 153 dyslexic families. For normal reading abilities the brain circuits communicate with each other. However when these circuits are disrupted thee is reading disability that presents as dyslexia. Although compensatory brain circuits are formed to compensate but these are ineffective in most of the children.

"We now have strong statistical evidence that a large number of dyslexic cases--perhaps as many as 20 percent--are due to the DCDC2 gene," said Gruen. "The genetic alteration on this chromosome is a large deletion of a regulatory region. The gene itself is expressed in reading centers of the brain where it modulates migration of neurons. This very architecture of the brain circuitry is necessary for normal reading."

The gene identification will provide a new tool for early diagnosis of dyslexia and more effective educational programs to address the unique needs and special talents of people with dyslexia.

Other authors on the study were Shelley D. Smith, Karl Hager, Matthew Held, Jonathan Liu, Richard K. Olson, Bruce F. Pennington, John C. DeFries, Joel Gelernter, Thomas O'Reilly-Pol, Stefan Somlo, Pawel Skudlarski, Sally E. Shaywitz, Bennett A. Shaywitz, Karen Marchione, Yu Wang, Murugan Parmasivam, Joseph J. LoTurco and Grier P. Page. The study to be published in a special issue of Proceedings of the National Academy of Sciences on October 28

Contact: Karen N. Peart karen.peart@yale.edu 203-432-1326 Yale University
'"/>




Related medicine news :

1. Chromosomes to predict oral cancer
2. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
3. Occupational Exposure To Radiation Causes Chromosome Aberrations
4. Chromosome Ends Trigger DNA Damage Response For Telomere Protection
5. Missing Chromosomes Revealed Brain Tumor Therapy Effect – Research Find
6. Cell Survival Depends on Chromosome Integrity
7. Using Multiphoton Microscopy to See Chromosomes in Action
8. Nicotine Dependence Gene Mapped to Chromosome 5
9. Dyslexia due to cerebellum abnormality
10. Dyslexia may slow a drivers reaction time as much as moderate drinking!!
11. Dyslexia Gene Identified and Called "KIAA0319"
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... ... February 24, 2017 , ... With millions of Americans ... important that we all are aware of our options and are empowered with ... announce the launch of its newest edition of "Vision and Hearing" in USA ...
(Date:2/24/2017)... CA (PRWEB) , ... February 24, 2017 , ... The ... 2017 national conference convening academic faculty engaged in or interested in palliative care education ... Research,” will be held in North County San Diego on Sept. 28 and ...
(Date:2/24/2017)... ... February 24, 2017 , ... The Radiology Business ... in radiology marketing programs at the annual Building Better Radiology Marketing Programs ... Worth Hotel in Fort Worth, Texas. Nine awards are given out in five categories. ...
(Date:2/23/2017)... ... 2017 , ... Thinksport, the most award-winning sunscreen on the ... Marin. For the second year in a row, cyclists will stay protected from ... thrilled to provide our safe, non-toxic sunscreen to over 2,000 cycling enthusiasts again ...
(Date:2/23/2017)... ... 23, 2017 , ... Rare Disease Report®, which is the ... Rare Disease Day events, hosted by the Rare Disease Legislative Advocates (RDLA) on ... weekly e-newsletter and quarterly publication, will be conducting interviews with patients and advocates ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... BRISBANE, Australia , Feb. 23, 2017  Directors from Pharma ... the two companies have joined forces, resulting in the founding of ... . Pharma To Market are pleased to announce their ... an office in Singapore . The company are ... Consulting as Co-Director of the Singapore based ...
(Date:2/24/2017)... , Feb. 23, 2017 ... insights on the various drugs being developed ... covers all the drugs that are in ... Clinical). The pipeline focuses on novel pharmacologic ... antibodies, stem cell therapies, recombinant proteins and ...
(Date:2/24/2017)... Feb 24, 2017 Medivir AB ... for a new Board of Directors that will be ... Nomination Committee comprises representatives of the company,s three largest ... 2016 who have accepted a seat on the Nomination ... of the 2016-2017 Nomination Committee was as follows:  ...
Breaking Medicine Technology: