Navigation Links
Cholesterol mystery solved through research mice

Researchers at the Wake Forest University School of Medicine developed a breed of research mice to decipher the complexities of cholesterol//.

It studies how "good" cholesterol is used by the body to protect against heart attacks and strokes.

According to John S. Parks, Ph.D., from Wake Forest University School of Medicine, “Being able to develop drugs to raise levels of good cholesterol depends on knowing more about the how and where the particles are formed. These animals provide the first tools to address these questions."

These specially developed mice have mutations in a gene (ABCA1) involved in HDL production. In one group of animals, the ABCA1 gene is selectively deleted in the liver – which means their livers cannot produce HDL. It was through studying these mice that the scientists were able to report in 2005 that the liver is likely the body's main source of good cholesterol – producing 70 to 80 percent.

Scientists also know that very small amounts of HDL are produced in macrophages, cells in the blood vessel walls that are involved in the formation of plaques. Through studying the third group of mice – which produces no HDL in the vessel walls – the scientists hope to answer a conundrum about this source of good cholesterol. Previous research indicates that while the levels of HDL produced in the vessels are very small, it may play a large role in keeping the vessels healthy.

"The animals can help us determine which pathways are affected by drug therapy, which can eventually be translated to human studies. They are a valuable tool in the quest to find a therapy to raise HDL concentrations and retard the development of heart disease,” said Parks. "

Page: 1

Related medicine news :

1. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
2. Eating More Often May Help Lower Cholesterol
3. Caution On Use of Cholesterol Drugs
4. High Cholesterol linked to Alzheimer’s diseas
5. Cholesterol Drug Helps After Angioplasty
6. Cholesterol lowering drugs increase neuropathy risk
7. Almonds Improve Cholesterol
8. Cholesterol-lowering therapy benefits older people also
9. Cholesterol lowering drugs aid people after heart transplant
10. New Cholesterol gene linked to Alzheimers
11. Children’s Cholesterol Matter
Post Your Comments:

(Date:11/30/2015)... Ill. (PRWEB) , ... November 30, 2015 , ... ... Decision Support Solutions, announced at the Radiology Society of North America (RSNA) annual ... have seen over 60% growth from 2014. Throughout 2015, the company has ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... automated breast density assessment and enterprise analytics solutions, here at the 101st ... (South Hall booth #2377). Volpara’s quantitative breast imaging tools enable personalized measurements ...
(Date:11/30/2015)... ... November 30, 2015 , ... It’s inevitable that everyone will experience ... friend, or animal pass away, death lives among us. It is your perspective, however, ... a family of 11 children, author T Sky understands that she may see death ...
(Date:11/30/2015)... , ... November 30, 2015 ... ... is pleased to announce the speakers for “Value-Based Payer-Provider Partnerships: Three Case ... from three innovative value-based care arrangements: Essentia Health and UCare, MissionPoint Health ...
(Date:11/30/2015)... , ... November 30, 2015 , ... The successful filing ... pharmaceutical company. Because it is so important to this key industry segment, Regis Technologies ... your IND Filing” on December 4th at 11am EST. , Federal law does not ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Cumberland Pharmaceuticals (CPIX), today announced that A.J. Kazimi ... December 3, 2015. TIME: 3:15p.m. ET LINK: ... --> DATE: Thursday, December ... --> --> This will ... to ask the company questions in real-time - both in ...
(Date:11/30/2015)... Nov. 30, 2015 Varian Medical Systems (NYSE: VAR ... educational partnership with Apollo Hospitals Group, the largest hospital chain in ... help train radiation technologists in the country. The MoU was signed ... Knowledge, and Ashok Kakkar , Varian,s India ... India , Varian intends to deploy its Access ...
(Date:11/30/2015)... , November 30, 2015 PFE ... at up to 10 G protein-coupled receptor (GPCR) targets ... to research and develop potential new medicines directed at ... multiple therapeutic areas. --> Heptares Therapeutics ("Heptares"), ... and wholly-owned subsidiary of Sosei Group Corporation ("Sosei"; TSE ...
Breaking Medicine Technology: