Navigation Links
Cholesterol mystery solved through research mice

Researchers at the Wake Forest University School of Medicine developed a breed of research mice to decipher the complexities of cholesterol//.

It studies how "good" cholesterol is used by the body to protect against heart attacks and strokes.

According to John S. Parks, Ph.D., from Wake Forest University School of Medicine, “Being able to develop drugs to raise levels of good cholesterol depends on knowing more about the how and where the particles are formed. These animals provide the first tools to address these questions."

These specially developed mice have mutations in a gene (ABCA1) involved in HDL production. In one group of animals, the ABCA1 gene is selectively deleted in the liver – which means their livers cannot produce HDL. It was through studying these mice that the scientists were able to report in 2005 that the liver is likely the body's main source of good cholesterol – producing 70 to 80 percent.

Scientists also know that very small amounts of HDL are produced in macrophages, cells in the blood vessel walls that are involved in the formation of plaques. Through studying the third group of mice – which produces no HDL in the vessel walls – the scientists hope to answer a conundrum about this source of good cholesterol. Previous research indicates that while the levels of HDL produced in the vessels are very small, it may play a large role in keeping the vessels healthy.

"The animals can help us determine which pathways are affected by drug therapy, which can eventually be translated to human studies. They are a valuable tool in the quest to find a therapy to raise HDL concentrations and retard the development of heart disease,” said Parks. "
br>
'"/>




Page: 1

Related medicine news :

1. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
2. Eating More Often May Help Lower Cholesterol
3. Caution On Use of Cholesterol Drugs
4. High Cholesterol linked to Alzheimer’s diseas
5. Cholesterol Drug Helps After Angioplasty
6. Cholesterol lowering drugs increase neuropathy risk
7. Almonds Improve Cholesterol
8. Cholesterol-lowering therapy benefits older people also
9. Cholesterol lowering drugs aid people after heart transplant
10. New Cholesterol gene linked to Alzheimers
11. Children’s Cholesterol Matter
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Pixel Film ... Pro X. , "Film editors can give their videos a whole new perspective by ... Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the ... AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in ... topics including advance care planning, healthcare costs and patient and family engagement. , ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... First ... United States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell ... facility Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether ... latter, setting the bar too high can result in disappointment, perhaps even self-loathing. However, ... their goal. , Research from PsychTests.com reveals that behind the tendency ...
(Date:6/24/2016)... PASADENA, CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. ... he would lash out at his family verbally and physically. , “When something upset him, ... table, he would use it. He would throw rocks at my other children and say ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: