Navigation Links
Cholesterol Plays An Important Role In Finger and Toe Development

The next time you would like to thank somebody for a complete set of 20 digits after counting your newborn's fingers and toes, cholesterol might be all that you need to be grateful for //!

A new study conducted in mice has now found that cholesterol plays a very vital role in development of fingers and toes. The attachment of this pivotal chemical to a specific development protein is the key to proper digit development. Mice devoid of cholesterol developed digits in wrong places, in addition to extra digits. The results of this interesting study have been found in the online edition of the Proceedings of the National Academy of Sciences.

Although the developmental protein named Sonic hedgehog, has been identified as early as 1990, the association of the protein with cholesterol has remained unclear. Previous studies had established that mice lacking the protein developed only a single digit, commonly in the form of a thumb on the front paw.

A specialized group of cells situated at the posterior part of the developing limb bud produce the protein. High concentrations of the protein are found at the site of synthesis. Gradually, it diffuses across the limb bud. The identity of the other digits is dictated by the decreasing concentration of the protein. That a cholesterol molecule had to be attached to the protein, for it to work properly, was found out by further research.

'Questions have remained about what regulates the Sonic hedgehog gradient. And we've been working on that for a number of years. In fact, Sonic hedgehog is the only protein known to be modified by cholesterol,' said Chiang, a senior researcher who led the study.

To further establish the role of cholesterol in functioning of the protein, the researchers created mice that had an altered form of the Sonic hedgehog protein. This ensured that the cholesterol molecule would remain free, as it cannot attach itself to the modified protein.

As exp ected, mice with the modified protein developed digits that were out of place or malformed digits. The index digits were further stunted and out of shape, seemingly more like a normal thumb. Special mice produced in which only 50% of the proteins could attach to cholesterol developed normal digits in addition to duplicated digits.

This duplication could be explained by the farther travel of Sonic hedgehog, than normal as a consequence of non-attachment to cholesterol molecule. 'We found that, without cholesterol, Sonic hedgehog moves more readily, far from its site of synthesis, all the way to the anterior part of the limb bud where it is normally never detected,' explained Dr. Chiang.

Polydactyly, a condition characterized by presence of extra digits, could by triggered by movement of Sonic hedgehog to a place, where it is normally not seen. The exact cause of polydactyly in humans is not completely understood. Although researchers now believe that mutations in some part of the Sonic hedgehog signaling pathway could be responsible for the same.

Sonic hedgehog signaling has been implicated in a number of birth defects such as deformities of spinal cord and brain (more specifically, holoprosencephaly, a congenital malformation of the forebrain) and certain types of cancer. The research group is currently doing more research on role of Sonic hedgehog in the development of the brain and spinal cord.

With our improved understanding of the wide-ranging actions of Sonic hedgehog and developmental biology, we could soon have valuable clues about prevention of birth defects, in the forth-coming years.


'"/>




Related medicine news :

1. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
2. Eating More Often May Help Lower Cholesterol
3. Caution On Use of Cholesterol Drugs
4. High Cholesterol linked to Alzheimer’s diseas
5. Cholesterol Drug Helps After Angioplasty
6. Cholesterol lowering drugs increase neuropathy risk
7. Almonds Improve Cholesterol
8. Cholesterol-lowering therapy benefits older people also
9. Cholesterol lowering drugs aid people after heart transplant
10. New Cholesterol gene linked to Alzheimers
11. Children’s Cholesterol Matter
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2017)... , ... August 17, 2017 , ... A recent report ... the biopharmaceutical industry in 2016 cited deficiencies in data integrity. The FDA outlines their ... 11 ruling. , Presented as part of the Beckman Coulter Life Sciences ...
(Date:8/16/2017)... Bethpage, NY (PRWEB) , ... August 16, 2017 , ... ... Kullen, Long Island’s original family-owned supermarket, has put together suggestions for enjoying the season ... new recipe or activity, everyone in the family can join in on the fun. ...
(Date:8/16/2017)... ... 16, 2017 , ... Blue Health Intelligence (BHI) announced today that ... Dr. Spiro brings over 30 years of clinical, healthcare IT, value-based care, and change ... solutions. , “I am thrilled to welcome Dr. Spiro to BHI,” said Swati ...
(Date:8/16/2017)... SEATTLE, Washington and CARTERSVILLE, Georgia (PRWEB) , ... August 16, 2017 ... ... list of the fastest growing companies in the U.S. for the second year in ... shown strong growth over the past three years. , “To be on the list ...
(Date:8/16/2017)... FL (PRWEB) , ... August 16, 2017 , ... ... standardized product data and images announced today that it was acquired by Advantage ... Industry’s solution for product information. IX-ONE’s members include the industry’s leading suppliers, brokers, ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... 4, 2017 The search for test results ... physician/patient consult has long been the goal of healthcare ... focus of the largest meeting of lab professionals and ... market research firm Kalorama Information.  The firm said scores ... or related supplies and software were at the American ...
(Date:8/2/2017)... BENTON, Ky. , Aug. 2, 2017   Marshall County Hospital in ... team to proactively reduce the risk of hospital-acquired infections (HAIs). The new addition, Tru-D ... UVC light energy to kill deadly pathogens such as C. diff , MRSA, MERS, ... Tru-D SmartUVC ... Tru-D in action in a patient room ...
(Date:7/31/2017)...  Diplomat Pharmacy, Inc. (NYSE: DPLO), has been named one ... by Crain,s Detroit Business . The annual ... three-year revenue growth. This year,s edition measures growth from 2013 ... the complete list, visit crainsdetroit.com/awards/fast_50/2017 .  ... said Phil Hagerman , CEO and chairman of Diplomat. ...
Breaking Medicine Technology: