Navigation Links
Cholesterol Mystery Solved By Nobel Laureates

A 72 year old mystery about cholesterol synthesis which has been bugging scientists for so long has finally been cracked by Nobel laureates. //

The Shoenheimer effect has long been unexplained, but not now. The first evidence for end-product feedback regulation of a biosynthetic pathway was demonstrated when Rudolph Shoenheimer observed that mice synthesized large amounts of cholesterol when fed a low-cholesterol diet, but this synthesis stopped when the mice were fed cholesterol.

In later years, many details of this cholesterol feedback were worked out, but the main mechanism by which cells in the liver sense cholesterol and thus regulate cholesterol production remained unknown.

Joseph Goldstein and Michael Brown finally solve the mystery of the Shoenheimer effect. The authors show that Insig (insulin-induced gene) proteins are essential components of this cholesterol feedback response. They create mice lacking the two mammalian Insig genes -– Insig1 or Insig2 in the liver. On a normal chow diet, the mice over accumulate cholesterol and fats in the liver, but levels of SREBP's and other SREBP target genes (molecules that sense cholesterol and regulate its synthesis) were not reduced. Normally, cholesterol intake reduces SREBP and the genes that synthesize cholesterol and fat, but this response was dysfunctional in the transgenic mice such that fat and cholesterol synthesis was not suppressed. The transgenic mice also had dysregulated levels of HMG-CoA reductase protein, the precursor for cholesterol synthesis.

The data presented indicate that the entire pathway for SREBP processing functions in the liver. Further, this pathway is responsible for the synthesis of cholesterol as well as the feedback suppression of synthesis when cholesterol is taken in from the diet.

Source: By Journal of Clinical Investigation
'"/>




Page: 1

Related medicine news :

1. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
2. Eating More Often May Help Lower Cholesterol
3. Caution On Use of Cholesterol Drugs
4. High Cholesterol linked to Alzheimer’s diseas
5. Cholesterol Drug Helps After Angioplasty
6. Cholesterol lowering drugs increase neuropathy risk
7. Almonds Improve Cholesterol
8. Cholesterol-lowering therapy benefits older people also
9. Cholesterol lowering drugs aid people after heart transplant
10. New Cholesterol gene linked to Alzheimers
11. Children’s Cholesterol Matter
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/30/2016)... (PRWEB) , ... May 30, 2016 , ... ... to use inside of FCPX," said Christina Austin - CEO of Pixel Film ... for use within Final Cut Pro X. Choose from abstract transitions to more ...
(Date:5/29/2016)... ... 29, 2016 , ... Whole Health Supply is happy to announce a new ... available to the public. This is an unusual clipper because it opens to a ... , Everything about this product is concentrated on ease of use, functionality and durability. ...
(Date:5/28/2016)... ... May 28, 2016 , ... After a year and a half of planning the Multiple ... The Multiple Pathways of Recovery Conference was held May 2 -4, 2016 at the ... United Kingdom came together to explore the many pathways individuals use to get into and ...
(Date:5/27/2016)... New Hampshire (PRWEB) , ... May 27, 2016 , ... ... skin care products, announced today that it has been recognized as one of the ... entering parenthood. Badger was named as one of nine small businesses providing progressive benefits ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... educate the many who are unaware of the plight of aphasia. In collaboration ... within the “Stroke Awareness” campaign. , The link between stroke and aphasia is ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... PUNE, India , May 30, 2016 /PRNewswire/ ... research report "Healthcare Analytical Testing Services Market by ... Monitoring, Bioanalytical Services), by End User (Pharmaceutical Companies, ... published by MarketsandMarkets, The market witnessed healthy growth ... grow at a CAGR of 11.3% between 2016 ...
(Date:5/30/2016)... , May 30, 2016 Eye expert ... of premature babies to seek an eye examination ... condition     Moorfields Eye Hospital Dubai, ... London , has identified premature babies as a ... because of their particular vulnerability to retinopathy of prematurity (ROP). ROP ...
(Date:5/27/2016)... 2016 Kitov Pharmaceuticals ... on late-stage drug development, today announced the completion ... pivotal batches required for registration of KIT-302 with ... follows Kitov,s announcement in December 2015, ... its primary efficacy endpoint. "We are ...
Breaking Medicine Technology: