Navigation Links
Cholesterol Mystery Solved By Nobel Laureates

A 72 year old mystery about cholesterol synthesis which has been bugging scientists for so long has finally been cracked by Nobel laureates. //

The Shoenheimer effect has long been unexplained, but not now. The first evidence for end-product feedback regulation of a biosynthetic pathway was demonstrated when Rudolph Shoenheimer observed that mice synthesized large amounts of cholesterol when fed a low-cholesterol diet, but this synthesis stopped when the mice were fed cholesterol.

In later years, many details of this cholesterol feedback were worked out, but the main mechanism by which cells in the liver sense cholesterol and thus regulate cholesterol production remained unknown.

Joseph Goldstein and Michael Brown finally solve the mystery of the Shoenheimer effect. The authors show that Insig (insulin-induced gene) proteins are essential components of this cholesterol feedback response. They create mice lacking the two mammalian Insig genes -– Insig1 or Insig2 in the liver. On a normal chow diet, the mice over accumulate cholesterol and fats in the liver, but levels of SREBP's and other SREBP target genes (molecules that sense cholesterol and regulate its synthesis) were not reduced. Normally, cholesterol intake reduces SREBP and the genes that synthesize cholesterol and fat, but this response was dysfunctional in the transgenic mice such that fat and cholesterol synthesis was not suppressed. The transgenic mice also had dysregulated levels of HMG-CoA reductase protein, the precursor for cholesterol synthesis.

The data presented indicate that the entire pathway for SREBP processing functions in the liver. Further, this pathway is responsible for the synthesis of cholesterol as well as the feedback suppression of synthesis when cholesterol is taken in from the diet.

Source: By Journal of Clinical Investigation
'"/>




Page: 1

Related medicine news :

1. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
2. Eating More Often May Help Lower Cholesterol
3. Caution On Use of Cholesterol Drugs
4. High Cholesterol linked to Alzheimer’s diseas
5. Cholesterol Drug Helps After Angioplasty
6. Cholesterol lowering drugs increase neuropathy risk
7. Almonds Improve Cholesterol
8. Cholesterol-lowering therapy benefits older people also
9. Cholesterol lowering drugs aid people after heart transplant
10. New Cholesterol gene linked to Alzheimers
11. Children’s Cholesterol Matter
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of sub-acute ... of a disaster drill on October 3rd. , Apple Rehab participated with the Shelton ... well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The LTC-MAP ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed ... geared towards children of all ages; it is a non-competitive, non-timed event, which is ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... LA (PRWEB) , ... October 12, 2017 , ... Planet ... in the U.S., announced today its plans to open a flagship location in Covington, ... occupy the former Rooms To Go store next to Office Depot in the Holiday ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... leader in post-acute health care, have expanded their existing home health joint venture ... , AccentCare has been operating a joint venture home health company with Asante, ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Texas , Oct. 11, 2017  Caris Life ... focused on fulfilling the promise of precision medicine, today ... has joined Caris, Precision Oncology Alliance™ (POA) as its ... cancer centers, the St. Jude Crosson Cancer Institute will ... advance the use of tumor profiling, making cancer treatment ...
(Date:10/7/2017)...   Provista, a proven leader in the ... purchasing power, today announced a new resource area on ... is the online home for case studies, articles ... news releases, slideshows and events. ... resources at their fingertips, viewers can also watch short ...
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
Breaking Medicine Technology: