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Chilean President's Cousin Successfully Tests Allergy 'Knockout' Technique on Mice

on with serious consequences.

With a view to overcome this problem, Bachelet and his research colleague Ariel Munitz have designed a small, synthetic, antibody fragment that has the unusual ability of recognizing two targets simultaneously-the receptor CD300a and a mast cell-specific marker. This makes the antibody targets CD300a only on the surface of mast cells, avoiding suppression of other immune cells.

During the study, this antibody potently eliminated four different types of allergic diseases in mice. The researchers also noted that upon administration of the antibody in nose drops, mice suffering from sever chronic asthma completely reverted to normal in less than two months.

Termed RECEPTRA, the pioneering project presents a novel therapeutic strategy for acute and chronic allergic diseases, and is currently being licensed through Yissum, the Hebrew University's technology transfer company, to pharmaceutical companies for further development and eventual clinical trials.

Bachelet predicts that with further development, his technology may become the first line of allergy therapy in the near future.


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