The early progression of chronic kidney disease in children and teens is poorly understood, but a national research team led by //Johns Hopkins scientists is launching the largest-ever study to learn more about this often-stealthy killer.
“There has never, to our knowledge, been a study designed to systematically assess the changes in kidney function over time in children with early kidney disease and to determine how these changes affect behavior, learning, heart disease risk and growth,” says Susan Furth, M.D., Ph.D., a nephrologist at the Johns Hopkins Children’s Center, one of the project’s three principal investigators and lead author of a report on the study, appearing in the Clinical Journal of the American Society of Nephrology.
This NIH-funded, 57-center study hopes to follow over a period of four years 540 children ages 1 through 16 with mild to moderate kidney disease. The Johns Hopkins Children’s Center is one of two clinical coordinating sites, along with the Children’s Hospital at the University of Missouri-Kansas City. The Johns Hopkins Bloomberg School of Public Health is the study’s data coordinating center.
Researchers will collect blood, urine, fingernail and hair samples and will monitor kidney function, height, weight, blood pressure and heart disease by the use of echocardiograms. Periodic surveys are planned to track everything from quality of life and social and cognitive development to sexual maturation during puberty, which is often delayed in teens with kidney disease. Patients will fill out questionnaires detailing everything from symptoms, to use of medications and dietary supplements, to lifestyle and exercise. Researchers will harvest cell lines to study the genetic elements of kidney disease.
Results will be reported incrementally, but some preliminary findings are already in. For example, using data from the pilot study, researchers have refined an existing method - used mostly in EuropePage: 1 2 Related medicine news :1
. Children’s Cholesterol Matter2
. Extensive Campaigning To Warn Against Children’s Growing Affinity To Fast Food In Britai3
. Children’s Stress Levels Directly Related To Maternal Job Satisfaction4
. POCKET To Protect Children’s Privac5
. Children’s obesity linked to video game6
. Children’s Health Improves By Swimmin7
. Teething Problems – Fight Sugar For Children’s Dental Healh8
. Older Teenagers Too To be Treated In Children’s Hospital9
. Parents Unaware of their Children’s Knowledge about Household Firearm10
. Research Documents Children’s Exposure to Pesticide11
. Parental Time Influences Children’s Nutritio