Navigation Links
Childhood Survivors Of Brain Tumors More At Risk For Strokes Later In Life

According to a new research from UT Southwester Medical Center, children who were treated successfully for leukemia or brain tumors are more at risk for strokes later in life. //

In addition, childhood cancer survivors who received higher doses of cranial radiation therapy to kill the cancer showed even greater risk of stroke in later life, according to the study, which appears in the Nov. 20 issue of the Journal of Clinical Oncology and is available online.

"This is important because leukemia and brain tumors are the two most common types of childhood cancer, representing more than half of childhood cancers," said Dr. Daniel Bowers, associate professor of pediatrics and lead author of the study.

Other studies have shown that survivors of childhood leukemia or brain cancer are also at higher risk for cardiac dysfunction, obesity, short stature, and hormone and neurocognitive deficits. This is the first study to examine the risk to survivors for late-occurring strokes, which occur at least five years after their cancer diagnosis.

Leukemia and brain tumors account for 53 percent of all cancers among children younger than 15 years of age and are annually diagnosed in more than 4,400 U.S. children. Most patients live at least five years beyond their diagnosis to become long-term cancer survivors – 79 percent for leukemia and 73 percent for brain tumors.

The peak incidence for both leukemia and brain tumors is during vulnerable neurocognitive development, so researchers suspect that the radiation therapy typically received at such a crucial time may influence the later risk for stroke.

Among the study's findings:
  • Compared with siblings, leukemia survivors were two to three times more likely to suffer a stroke. Brain-cancer survivors were eight to 10 times more likely to suffer a stroke.

  • Brain-tumor survivors treated with radiation therapy were 15 times more likely to suffer a strok e.

  • Patients with a history of relapse of their cancer were at a greater risk for stroke, likely a result of increased radiation treatment, the researchers concluded.

  • The effects of late-occurring strokes, which can be life-threatening or result in permanent or severe disability, can be particularly devastating in these cases because they often hit when the childhood cancer survivors are reaching early adulthood – in their late 20s and early 30s.

    "Many people think, 'You're five years out from your cancer, you must be cured, and you can get on with the rest of your life.' But these patients suddenly develop a new complication of the cancer and its treatments," Dr. Bowers said.

    UT Southwestern is one of 26 sites participating in the Childhood Cancer Survivors Study on long-term side effects for cancer survivors. Children's Medical Center Dallas is also a member and contributed patients to the study. The study established a database of information on some 14,000 patients who survived at least five years after being diagnosed with cancer during childhood. The national database includes about 4,000 leukemia survivors and about 1,700 survivors of brain tumors.

    Dr. Bowers has been culling through the data involving strokes, and previously discovered a greater stroke risk for survivors of Hodgkin disease.

    Brain tumors and leukemia might seem like apples and oranges because leukemia is a bone - marrow cancer and brain cancers are by definition tumors in the brain.

    "But they are similar in important ways," Dr. Bowers noted. "They both are most likely to occur in young childhood, and both groups also get targeted radiation therapy to the brain."

    The current treatment regiments for brain tumors and leukemia are aimed at reducing the use of radiation therapy, a move designed to lessen learning problems associated with radiation therapy.

    "It would be interesting to see whether it m ay also impact the occurrence of strokes," Dr. Bowers said.

    Researchers are now formulating a follow - up study to identify a way of screening patients who might be at risk of having strokes, with the goal of eventually developing a preventive strategy.

    Source-Eurekalert
    SR
    '"/>




    Related medicine news :

    1. Focused Treatment For Childhood Cancer
    2. Osteoporosis associated with Childhood Cancer
    3. Childhood Sunburn Can Lead to Skin Cancer Later
    4. Preventing Childhood Deaths
    5. Radiation Not Needed for Childhood Cancers
    6. Troubled Childhood found to affect your Liver
    7. Elevated LDL levels in Childhood could be Predictors of Heart Disease
    8. Persistent Childhood Wheeze Probably Inherited
    9. Childhood Weight Gain Found To Increase The Risk of Diabetes
    10. The Link Between Childhood Vaccinations And Diabetes Questioned
    11. Troubled Childhood found to affect your Liver
    Post Your Comments:
    *Name:
    *Comment:
    *Email:


    (Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
    (Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
    (Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
    (Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
    (Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
    Breaking Medicine News(10 mins):
    (Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
    (Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Global MEMS Devices Medical Market Analysis 2016 - Forecast to ... The report contains up to date financial ... reliable analysis. Assessment of major trends with potential impact on ... dive analysis of market segmentation which comprises of sub markets, ...
    (Date:6/23/2016)... , , , WHEN: , , ... , , , LOCATION: , , , Online, with free registration ... PANELISTS:  , , , Frost & Sullivan,s Global Vice President of ... Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... witnessing an exceptional era. Several new demand spaces, such as innovative ...
    Breaking Medicine Technology: