Navigation Links
Childhood Abuse Increases the Risk of Alcoholism

Researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH) found that girls who suffered childhood sexual abuse are more likely to develop alcoholism later in life if they possess a particular variant of a gene involved in the bodys response to stress.

The new finding could help explain why some individuals are more resilient to profound childhood trauma than others. With this study we see yet again that nature and nurture often work together, not independently, to influence our overall health and well-being, says NIH Director Elias A. Zerhouni, M.D.

This finding underscores the central role that gene-environment interactions play in the pathogenesis of complex diseases such as alcoholism, adds NIAAA Director Ting-Kai Li, M.D. A report of the study appears in the June 26, 2007 advance online publication of Molecular Psychiatry.

Previous studies have shown that childhood sexual abuse increases the risk for numerous mental health problems in adulthood. However not all abused children develop such problems, a likely indication that genetic factors also play a role. Recent studies have linked the monoamine oxidase A (MAOA) gene with adverse behavioral outcomes stemming from childhood mistreatment.

MAOA is an enzyme that metabolizes various neurotransmitters that regulate the bodys response to stress, explains first author Francesca Ducci, M.D., a visiting fellow in NIAAAs Laboratory of Neurogenetics in Bethesda, Maryland. DNA variations occur within a regulatory area the MAOA-linked polymorphic region (MAOA-LPR) -- of the MAOA gene.

Two such MAOA-LPR variants occur most frequently and result in high or low MAOA enzyme activity. In a recent study, researchers found that maltreated boys who possessed the low activity MAOA-LPR variant were more likely to develop behavior problems than boys with the high activity variant.

Our aim was to test whether this low activity variant influences the impact of childhood sexual abuse on alcoholism and antisocial personality disorder (ASPD) in women, says Dr. Ducci.

She and her colleagues analyzed DNA samples from a group of American Indian women living in a community in which rates of alcoholism and ASPD are about six times higher than the average rates among all U.S. women. Childhood sexual abuse is also prevalent in this population, reported by about half of the women in the community, compared with a U.S. average of 13 percent.

The high rates of sexual abuse and alcoholism in this population make it particularly suitable for studying the interaction of genes and stressful environmental exposures, explains senior author David Goldman, M.D., chief of the NIAAA Laboratory of Neurogenetics.

Analyses of MAOA-LPR genotypes in this study revealed that women who had been sexually abused in childhood were much more likely to develop alcoholism and antisocial behavior if they had the low activity variant whereas the high activity variant was protective. In contrast, there was no relationship between alcoholism, antisocial behavior and MAOA-LPR genotype among non-abused women.

Our findings show that MAOA seems to moderate the impact of childhood trauma on adult psychopathology in females in the same way as previously shown among males, says Dr. Ducci. The MAOA-LPR low activity allele appears to confer increased vulnerability to the adverse psychosocial consequences of childhood sexual abuse.

Dr. Ducci and her colleagues suggest that the effect of MAOA on the hippocampus, a brain region which is involved in the processing of emotional experience, may underlie the interaction between MAOA and childhood trauma. They note that previous research showed that people with the low activity variant at the MAOA-LPR locus have hyperactivation of the hippocampus when retrieving negative emotional information .


'"/>




Related medicine news :

1. Focused Treatment For Childhood Cancer
2. Osteoporosis associated with Childhood Cancer
3. Childhood Sunburn Can Lead to Skin Cancer Later
4. Preventing Childhood Deaths
5. Radiation Not Needed for Childhood Cancers
6. Troubled Childhood found to affect your Liver
7. Elevated LDL levels in Childhood could be Predictors of Heart Disease
8. Persistent Childhood Wheeze Probably Inherited
9. Childhood Weight Gain Found To Increase The Risk of Diabetes
10. The Link Between Childhood Vaccinations And Diabetes Questioned
11. Troubled Childhood found to affect your Liver
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... ... Tampa to offer patients with non-valvular atrial fibrillation (A-Fib) an alternative to long-term ... Since first offering the procedure in April of 2015, Florida Hospital Pepin Heart ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... use ultraviolet light A (UV-A) for photosynthesis, researchers Juntian Xu and Kunshan Gao ... brown seaweeds. The pair observed that when photosynthetically active radiation (i.e. the white ...
(Date:5/5/2016)... ... ... Derrin Doty Group has unveiled the latest charity campaign in their ongoing ... Seattle. The insurance provider’s caring team has been so moved by the sudden death ... from the flu, that they have decided to extend their original campaign. Compassionate community ...
(Date:5/5/2016)... ... 05, 2016 , ... The University of Western States (UWS) ... 2016 National SACA Leadership Conference on the Portland campus September 23-25. The conference ... come together and develop skills to be future leaders in the profession. ...
(Date:5/5/2016)... ... ... Vitenas Cosmetic Surgery has been named as one of the eight recipients ... and the Academy of Architecture for Health. The building, brainchild of founder Paul Vitenas, ... in October of 2014. , The prestigious Healthcare Design Awards are ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 5, 2016 ... addition of the  "Europe Thalassaemia Market and ... their offering.       (Logo: ... Europe Thalassaemia Market and Competitive Landscape Highlights ... pipeline products, Thalassaemia epidemiology, Thalassaemia market valuations ...
(Date:5/4/2016)... Holdings (NYSE: CODI ) ("CODI," "we," "our" ... businesses, announced today its consolidated operating results for the ... Quarter 2016 Highlights , Generated Cash Flow Available ... $13.6 million for the first quarter of 2016; ... first quarter of 2016; , Paid a first ...
(Date:5/4/2016)...  It,s time for an upgrade. There are many medical recorders on the market ... the illustrious DVMAXX HD  offers unparalleled connectivity and functionality.  Ampronix  is a renowned ... manufacturer of innovative technology.  Photo - http://photos.prnewswire.com/prnh/20160503/363416 ... ... ...
Breaking Medicine Technology: