Navigation Links
Chemo may not assist in fighting cancer

According to a study, for post-menopausal women with breast cancer that is affected by estrogen, chemotherapy may offer no benefit and a five-year course after surgery of tamoxifen, which obstructs the hormone, may be the only therapy needed. This finding could mean that some of the thousands of American women// diagnosed each year with breast cancer could avoid the debilitating side effects of taking drugs that chemically kill cancer cells and damage other cells in the body.

The study also found that for post-menopausal women whose breast cancer was not affected by estrogen, chemotherapy followed by tamoxifen offered the best hope of disease-free survival. Tamoxifen works by blocking the action of estrogen, a hormone that can promote the growth of cancer cells.

Richard D. Gelber, a biostatistician at the Dana-Farber Cancer Institute in Boston hopes that, this study will question the routine use of chemotherapy in the ER-positive (estrogen sensitive) group. The information should help physicians tailor cancer treatment for specific patients.

Dr. Andrew D. Seidman, a breast cancer specialist at Memorial Sloan-Kettering Cancer Center in New York City, said the study ``will reaffirm the way that many oncologists are now practicing'' and should help doctors base cancer therapies on the specific characteristics of their patients.

It shows chemotherapy is appropriate for some women, but not others, and that patients who need the therapy can be specifically identified based on the estrogen sensitivity of their tumors and on other factors, Seidman said.

The study, compiled by researchers from nine countries, was limited to breast cancer surgery patients who had completed menopause and whose disease had not spread to the lymph nodes. About 40 percent of the approximately 162,000 women in the United States diagnosed with breast cancer each year fit this category, the study said.

Researchers further divided the 1,550 patients in the study into groups based on whether their cancers were affected or not affected by estrogen. There were 350 in the study whose tumors were not affected by estrogen, described in medical terms as being estrogen receptor negative, or ER-negative. There were 1,000 who were ER-positive. For the remaining 75 patients, the ER status was unknown.

About half in each of these groups were treated with chemotherapy followed by five years of tamoxifen. The other half of each group received tamoxifen only. Researchers followed the patients for an average of almost six years and found the value of chemotherapy depended directly on the estrogen sensitivity of the patients' disease.

Among the ER-positive patients, chemotherapy provided no benefit. The five-year, disease-free survival rate for those who only took tamoxifen was 80 percent, while it was 84 percent for those who had both chemo and tamoxifen.

However, for the ER-negative patients, chemotherapy could be a life saver. The five-year, disease-free survival rate for those who had both chemo and tamoxifen was 82 percent. For ER-negative patients who took only tamoxifen, the survival rate was only 60 percent.

Gelber said the study may improve the lives of patients who are ER-positive because it will ensure they don't have to endure chemotherapy's side effects, such as hair loss, nausea and persistent tiredness. Gelber felt that there is a quality of life burden associated with chemotherapy. On the other hand, he said, the study showed that chemo's side effects were not severe enough that the therapy should be avoided by the ER-negative patients who would benefit. Gelber said a quality-of-life segment of the study showed the side effects from chemo are usually temporary and go away after the therapy ends.


Related medicine news :

1. Acupuncture May Help Chemotherapy Side Effects
2. Chemotherapy Pill Has Fewer Side Effects Than IV
3. Survival rates in breast cancer patients improved with "Dose Dense Chemotherapy"
4. Therapy Boosts Chemotherapy Effects
5. Chemotherapy Effective for Bladder Cancer
6. Hope for Chemo-Resistant Leukemia Patients
7. New Method Of Delivering Chemotherapy
8. Drug That Is Found To Reduce Heart Damage from Chemo
9. The Benefits Of Chemotherapy For Women With Ovarian Cancer
10. New Compound Could Strengthen The Effect Of Chemotherapy
11. Older Breast Cancer Patients Can Be Effectively Treated With Chemotherapy
Post Your Comments:

(Date:11/24/2015)... Leamington, ON (PRWEB) , ... November 24, 2015 , ... ... Innovations with Ed Begley Jr., airing first quarter 2016 via Discovery Channel. Dates and ... laws of the Province, and is in the business of producing and supplying medical ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... ... that the organization will waive paid entry and parking fees at several of ... and Monument Mountain in Great Barrington in support of REI’s Black Friday #OptOutside ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... share their knowledge and experiences at a live taping of the next ... for the Cure of Gastrointestinal Cancers 2015 Symposium at Georgetown University Hotel & ...
(Date:11/24/2015)... R.I. (PRWEB) , ... November 24, 2015 , ... With ... Amica Insurance is sharing safety tips to help protect your family and vehicle. , ... crashes around the 2013 Thanksgiving holiday weekend. Amica is sharing the following safety tips ...
(Date:11/24/2015)... ... November 24, 2015 , ... Chiropractic student Katie ... (CU-KC), in Overland Park, Kansas. Benson, a fifth-trimester student in the university’s ... Cleveland III on October 16. , “Katie is very excited and greatly appreciative ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... Solutions, Inc. (Pink Sheets: ASDS ) ("Ascendant" or the ... a special 1 percent stock dividend on the company,s common ... to shareholders of record December 7, 2015.  The dividend will ... stock. --> --> ... our confidence in Ascendant,s growth strategy as well as the ...
(Date:11/24/2015)... 24, 2015  Figure 1, a free mobile-first network ... cases, has launched a new completely redesigned web version ... allows radiologists, who work primarily on a desktop, to ... with its radiologist user base, Figure 1 is hosting ... North America (RSNA) Annual Meeting. ...
(Date:11/24/2015)... BEACH, Fla. , Nov. 24, 2015 /PRNewswire/ ... , has recently announced the launch of their ... --> ... --> --> ... for during travel and vacation, just got a ...
Breaking Medicine Technology: