Navigation Links
Chemo drugs cause cognitive decline in breast cancer patients

Chemobrain is a condition of cognitive decline experienced by several cancer patients receiving chemotherapy. This was confirmed by a recent study conducted on the // effect of chemotherapy on cognitive functions in mice.

Dr. Gordon Winocur of the Baycrest Research Centre for Aging and the Brain carried out the analysis at Trent University in association with Drs. Ian Tannock and Janette Vardy of Princess Margaret Hospital.

The study was published in the September 2006 issue of Pharmacology, Biochemistry and Behavior (Vol. 85, Issue 1) and will be available online next week. The findings were presented at a workshop held in combination with the 8th World Congress of Psycho-Oncology in Venice last week.

"In our study, we identified learning and memory deficits in the mild to moderate range in the drug-treated mice compared to the controls," says Dr. Winocur. "That the deficits were relatively small is encouraging. It's important that cancer patients continue with these drugs and know that if they experience mild to moderate impairments in their cognitive functions, this level of change is potentially manageable."

While there is growing evidence from studies of cancer patients on chemotherapy that the chemobrain effect does exist, many of the studies have suffered from methodological limitations. These include small samples, less than adequate controls and failure to account for other factors, including disease-related complications and stress, which could affect performance.

This latest study, using an animal model, afforded researchers the opportunity to look at the direct effects of chemotherapy drugs on cognitive performance without interference from potentially confounding variables.

In the study, 25 healthy female mice were split into two groups: the drug treatment group received standard doses of methotrexate and 5-fluorouracil (5FU), two drugs widely used in women to prevent recurrence of breast ca ncer; and the control group received a saline solution. Both groups were given their treatments over three weeks.

One week after the final injection they were put through a series of spatial/non-spatial memory tests and conditional rule learning tests in a water maze. The behavioral tasks enabled investigators to assess various aspects of learning and memory associated with different brain regions. The drug treatment group scored lower on the spatial memory task (hippocampus) and the task requiring strategic and working memory components (frontal lobes), especially when there were long delay intervals, compared to the control group. The drug group was not impaired on a cued memory test or in discrimination learning, tasks that are not affected by selective damage to the frontal lobes or hippocampus.

"This indicates that the adverse effects of this treatment regimen of methotrexate and 5FU probably do not extend to all regions of the brain. It appears that the hippocampus and frontal lobes are primarily affected," says Dr. Winocur.

Because the behavioral testing was initiated two weeks after the last treatment and completed within four to five weeks, the study assessed only the short-term effects of the drugs. This is important because it raises the possibility that at longer treatment intervals there might have been some recovery of cognitive function, notes Dr. Winocur.

Source-Eurekalert
GYT
'"/>




Related medicine news :

1. Acupuncture May Help Chemotherapy Side Effects
2. Chemotherapy Pill Has Fewer Side Effects Than IV
3. Survival rates in breast cancer patients improved with "Dose Dense Chemotherapy"
4. Therapy Boosts Chemotherapy Effects
5. Chemotherapy Effective for Bladder Cancer
6. Hope for Chemo-Resistant Leukemia Patients
7. New Method Of Delivering Chemotherapy
8. Drug That Is Found To Reduce Heart Damage from Chemo
9. The Benefits Of Chemotherapy For Women With Ovarian Cancer
10. New Compound Could Strengthen The Effect Of Chemotherapy
11. Older Breast Cancer Patients Can Be Effectively Treated With Chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... ... December 08, 2016 , ... The West Virginia ... 1, 2017. The name change aligns the entire company with its existing ... care quality. , “We are very proud of the achievements associated with the ...
(Date:12/8/2016)... ... December 08, 2016 , ... After enjoying record-breaking attendance at ... for its 33rd Annual Issues & Research Conference, March 2-3, 2017, at ... the conference is “Persistent Challenges and New Opportunities: Using Research to Accelerate the ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... “Natural Language Processing–Enabled and Conventional Data Capture Methods for Input to Electronic Health ... . , Results of the comparative usability study demonstrate that a dictation-based method ...
(Date:12/8/2016)... ... December 08, 2016 , ... Mirixa Corporation , a ... other pharmacist-delivered patient care services, has announced the promotions of Karen Litsinger to ... president of sales. , Litsinger joined Mirixa in 2008 after serving as ...
(Date:12/8/2016)... ... ... With the increasing demand for dental implants, the National Association of Dental ... dentists and patients about the safety issues related to dental restorations. According to the ... is projected to reach $6.4 billion in 2018 with more than 30 million Americans ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... QUEBEC CITY , Dec. 8, 2016 /PRNewswire/ ... key US patents for improving the accuracy, reproducibility ... CD images in long and small bone orthopaedic ... proprietary approach to creating personalized orthopaedic restorations based ... create personalized orthopaedic restorations, the company harnesses the ...
(Date:12/8/2016)...  A new study by a pair of Geisinger ... therapy to treat chronic pain is not only ineffective, ... consequences, including death. Palliative care physicians ... , M.D., authored the study which provides a review ... study was published in the December 2016 edition of ...
(Date:12/8/2016)... Information products and services provider Elsevier has launched ... world,s largest abstract and citation database of peer-reviewed literature, providing the ... 5,000 publishers. The new set of metrics will improve decisions on ... adjust a journal,s editorial strategy. ... , CiteScore metrics comprise ...
Breaking Medicine Technology: