Navigation Links
Change in Course of Treatment: Exploring Better Ways

At the Annual Meeting of the American Society of Clinical Oncology today, the results of a large, multicenter, international study laying the groundwork for decisions that included when or if a change in treatment should be made were presented.

In patients with metastatic colorectal cancer, counting circulating tumor cells before and after the start of treatment could help doctors decide when and if a change in course of treatment is necessary.

Few studies have examined the relationship of CTC and a patient's prognosis in cancer. This is an important area of research in metastatic colorectal cancer because there are little data to help physicians chose which treatment is best for which patients or to determine when a change in treatment is warranted.

"If we had a way to know early on that a tumor isn't responding to a particular drug, we could switch to a different treatment before growth of the cancer is seen on a CAT scan," said Neal J. Meropol, director of the gastrointestinal cancer program at Fox Chase Cancer Center and lead investigator of the study. "If we could determine that the tumor was destined to grow after a few weeks of treatment, we'd be able alter course even before the first scan."

For this study, Meropol and his colleagues examined the association between the circulating tumor cell number and progression-free and overall survival for 430 adult patients with metastatic colorectal cancer.

The number of CTC was measured at baseline, one month, and several other points after the start of treatment. CTC were isolated and counted by an immunomagnetic cell separation technique, an FDA-approved technology developed by Immunicon Corporation. CT scans were obtained in usual practiceat baseline and every 6-12 weeks after starting treatment. Having 3 or more CTC (per 7.5 mL of blood) was defined as "unfavorable" in an initial analysis. Patients with fewer than 3 CTC were considered favorab le.

Before initiation of the first treatment (baseline), 53 percent of patients had no detectable CTC. These patients had superior median survival times compared with those patients who had circulating tumor cells. A favorable CTC number before treatment is associated with better progression free survival and overall survival.

In addition to its predictive value at baseline, the CTC was also a strong indicator of prognosis as early as 3-5 weeks after treatment initiation. "Patients with unfavorable CTC had a shorter median survival time. This was even seen in those patients whose CT scan the gold standard for tumor evaluation- indicated no disease progression," Meropol explained.

The median overall survival of patients with a favorable CTC before treatment was almost double that of those with an unfavorable CTC (18.5 months vs. 9.4 months). Patients with a favorable CTC had a median progression free survival of 7.9 months and those with an unfavorable CTC had a progression free survival of 4.5 months. The measurement of CTCs consistently provided prognostic information even when tested at 6-12 weeks.

Another key finding was the predictive value of a change in CTC. Among patients with unfavorable CTC at baseline, those whose numbers decreased after treatment to fewer than 3 had improved progression-free survival and overall survival.

"Potentially, this tool could be useful in the clinic to make real-time decisions about whether a treatment is helping. Our ultimate goal is to continue effective treatment, but spare patients the side effects of a treatment that is destined to fail. This is the direction that future studies must take."


'"/>




Related medicine news :

1. GlaxoSmithKline - Changes Lamictal(R) Label Appearance and Packaging
2. Change in walking might indicate Dementia
3. Change in weight not a risk in healthy men
4. Changes in cabin pressure pose risks for moms-to-be
5. Dietary Changes Could Reduce The Risk for Stroke
6. Link Between High Blood Sugar And Behavioral Changes
7. Improving Lighting Could Bring About A Change In Alzheimers Patients
8. Specific Changes In A Particular Gene Found To Increase The Risk of Alzheimer’s Diseas
9. Impotence Drugs Ordered by FDA to have Label Change
10. Ultrasounds To Detect Changes In Heart Motions
11. Change In Diet May Slow The Progression Of Prostate Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... in scholarships to students studying complementary medicine. Allison Outerbridge is this year’s ... her award on May 18 at the university’s Student Leadership Awards ceremony. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... There are many ways to cook a hot ... suggests that Americans prefer their dogs straight off the grill. Of the 90 percent ... favorite way to cook a hot dog, far outpacing other cooking methods such as ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... ... and clinical outcomes, hosted members and suppliers for its inaugural Member Conference at ... on their mission of elevating the operational health of America’s healthcare providers. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... On Memorial Day, Hope ... lost their lives in military battle for the country. The nonprofit Hope For ... provide more programs that empower independence for disabled military veterans, as well as police, ...
(Date:5/26/2016)... ... May 26, 2016 , ... There are nearly 14.5 million people living with ... worldwide. On Sunday, June 5, 2016, communities around the world will gather to recognize ... , National Cancer Survivors Day® is an annual worldwide Celebration of Life that is ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... Digital Health Dialog, LLC dba EngagedMedia ... US Patent and Trademark Office of U.S. Patent ... for electronic opt-­in and processing of discount coupons ... compliance and otherwise. Logo - http://photos.prnewswire.com/prnh/20160524/371583LOGO ... "Our technology allows for individuals to opt­-in to ...
(Date:5/24/2016)... , May 24, 2016 ... Markt gebracht, die es Ärzten erlaubt, ihre Expertise ... behandeln: MDLinking kombiniert Live Streaming mit einer Instant-Messaging-Funktion ... zu kommunizieren. Mediziner in Europa, Afrika, Asien und ... bereits für die Plattform registriert. Information ...
(Date:5/24/2016)... HENDERSON, Nev. , May 24, 2016  Diana ... painfully "eats" her organs from the inside out.  This ... her completely dependent on her children and grandchildren to ... of her wheelchair, Diana,s family cannot haul the wheelchair.  ... rides in the car, and Diana is left to ...
Breaking Medicine Technology: