Navigation Links
Cellular Pathway Yields Potential New Weapon in Vaccine Arsenal

When a cell has to destroy any of its organelles or protein aggregates, it envelops them in a membrane, forming an autophagosome// , and then moves them to another compartment, the lysosome, for digestion.

Two years ago, Rockefeller University assistant professor Christian Münz showed that this process, called autophagy, sensitizes cells for recognition by the immune system’s helper T cells. But he didn’t know how often this pathway is used or how efficient it is. Now, a new study published online today in the journal Immunity goes a long way toward addressing these questions and shows that the pathway is so common that it could be a valuable new way of boosting vaccine efficacy.

There are two types of T cells: Helper T cells encourage their counterpart, killer T cells, to hunt down and attack invading pathogens. T cells typically recognize antigens only once they’re presented to them by major histocompatibility compex (MHC) scaffolding molecules on a cell’s surface. Antigens on MHC class I molecules are recognized by killer T cells and had originally been thought to come only from sources inside a cell (proteins from the nucleus or other cellular part); those on MHC class II molecules are recognized by helper T cells and had been thought to come from sources outside the cell, such as fragments of dead, infected cells. But as Münz discovered two years ago, an autophagy pathway allows intracellular antigens to be presented on MHC class II molecules.

Now Münz, head of Rockefeller’s Laboratory of Viral Immunobiology, and Dorothee Schmid, a graduate student in the lab, have shown that the autophagy pathway is far more widespread than they thought: They found that a surprising number of cells with MHC class II molecules on their surfaces used the autophagy pathway. In skin (epithelial) cells and two other types of immune cells (dendritic and B cells), 50 to 80 percent of the autophagosomes moved into the loading compartment for MHC cl
'"/>




Page: 1 2

Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
3. Unchecked Cellular Repair Pathway Causes Liver Cancer
4. New Way to Open Cellular Ion Channels, Implications for Drug Design
5. Cellular System Causing Destruction Of Faulty Proteins In Cystic Fibrosis Identified
6. Gene May Regulate Cellular Aging
7. Cellular Cues Identified for Stroke Recovery
8. Cocaines Use During Pregnancy May Cause Lasting Cellular Effects
9. Scientists Identify Cancer Pathway
10. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
11. Unchecked Cellular Repair Pathway Causes Liver Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cellular Pathway Yields Potential New Weapon Vaccine Arsenal

(Date:8/1/2015)... ... August 01, 2015 , ... On March 19, 2015 Phil Valentine – the Executive Director ... Appalachian Trail by stepping off Springer Mountain and heading north. Since that day, ... Phil reached Connecticut and was greeted by friends and family. He visited CCAR and ...
(Date:7/31/2015)... ... July 31, 2015 , ... When the weather turned hot and ... new type of sod called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) for ... commemorate introduction of this new type of sod, Super-Sod is giving away red Adirondack ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Ticket Down ... is currently going on in Chicago at Grant Park. The festival will end ... of North America to Chicago for the annual Lollapalooza. This unique and unbelievably ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... run by GoodThreads. The store can be accessed by visiting http://www.curemeso.org/store . ... which are customizable. The best part: whenever a product is purchased, the Meso ...
(Date:7/31/2015)... , ... July 31, 2015 , ... There’s no better ... even when it comes time to cook the next meal, making July the most ... by practicing best grilling tips and recipes. , Make the next cookout different than ...
Breaking Medicine News(10 mins):Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3
... parents’ when compared to rugby-codes. But this opinion stands challenged, ... for the highest injuries as compared to all other types ... topped the charts of contact sports injuries, the second place ... and the last , being soccer. ,A report published ...
... suspected to have contacted meningococcal disease are being treated at ... who hail from Cobar and Mudgee respectively, are showing signs ... possible to relate both the cases, based on the evidence ... Western Area Health Service. In addition, family members and friends ...
... SOS has found that firms are concentrating on "tracking ... than stockpiling protective equipment like gloves and masks in ... // ,The survey found that only 36 of ... steps, "Organizations with distributed, global workforces want to be ...
... expression pattern of certain microRNA’s heve been found that ... ,The analysis of these findings indicates that miRNAs may ... for lung cancer. ,The Ohio State University ... of Medicine, Tokyo, Japan; National Cancer Centre Research Institute, ...
... LONDON - A drug trial in northwest London went horribly ... trial are now battling for life at the emergency ward ... in the trial of a drug to treat conditions such ... volunteers were given a placebo and were healthy, but the ...
... frozen embryos are stored in Britain. They are living balls of ... their lives to begin again. // , Lois Walker ... was born in April 2000. Her gestation period lasted for more ... been an eight-celled embryo and spent about 30 months in a ...
Cached Medicine News:Health News:Lung cancer molecular profile discovered by researchers. 2Health News:Frozen embryos stored in Britain 2
(Date:7/31/2015)... 2015 More than 1,500 substance abuse prevention ... in Indianapolis Aug. 2-6 for ... Training Institute . The week-long training, held at the ... of our nation,s biggest public health challenges – youth ... is a one-of-a-kind intensive training opportunity, offering more than ...
(Date:7/31/2015)... , July 31, 2015  Boston Children,s ... benefiting from 3D printing of their anatomy before ... life-threatening cerebrovascular malformations (abnormalities in the brain,s blood ... Reporting online today in the Journal of ... of 3D printing and synthetic resins to create ...
(Date:7/31/2015)... 2015 Egalet Corporation (Nasdaq: EGLT ... focused on developing, manufacturing and marketing innovative pain ... announced underwritten public offering of 7,666,667 shares of ... of $11.25 per share. The shares of common ... upon the exercise in full by the underwriters ...
Breaking Medicine Technology:Community Leaders From Across The Country Head To Indianapolis For CADCA 2015 Mid-Year Training Institute Aug. 2-6 23D Printing Helps Doctors Rehearse Complex Brain Procedures 23D Printing Helps Doctors Rehearse Complex Brain Procedures 33D Printing Helps Doctors Rehearse Complex Brain Procedures 4Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4
The ImagingPlanet 55 mm Surgical Microscope Adapter. Superior optical quality and precise engineering make this 55mm focal length adapter an excellent decision for use with your Zeiss surgical micro...
... Capture Archive Manage ... Images. ,Introducing Optronics DVMR- office, ... system designed for the physician's ... from a variety of high-resolution ...
... Optronics QuantiFIRE represents the latest innovation ... scientific grade CCD imaging for microscopy. ... Monochrome CCD camera developed exclusively for ... fluoresence or NIR imaging applications where ...
... This system is the most ... world. Developed in the USA after ... safety, and complete precision with maximum ... exfoliation. It is superior to traditional ...
Medicine Products: