Navigation Links
Cause of ‘Down Syndrome’ cannot be pinned down to maternal age aloe

New study unravels that other factors play a strong role along with maternal age in determining the incidence of Down's Syndrome.// Many older women who have been either contemplating a planned pregnancy or have found out that they are pregnant often find themselves reeling under the heavy load of traditionally handed down fears of the possibility of having to go through a pregnancy were the chances of the fetus (unborn developing baby) being malformed or mentally challenged, owing to their advanced age.

Well, though the theory is not just a punch in the air, as its medically proven that older women do stand a greater risk in having to give birth to a child afflicted with ‘Down’s Syndrome’. However, recent research has also brought to the fore other factors alsowhich play a role.

Markus Neuh?user and Sven Krackow researchers from the Institute of Medical Informatics, Biometry and Epidemiology at University Hospital Essen, in Germany point out that the chances for a baby to be born with Down’s Syndrome would also depend on the number of children that have been already borne by his mother and also on the age difference he shares with his nearest sibling.

Their studies based on actual data which data back to a period( when abortions were certainly not in vogue!)from 1953 to 1972, show that the rates of incidence of Down’s Syndrome is often considerably higher in older women going through their first pregnancy than older women who have already borne children. Getting Pregnant for the first time around at a later age can be riskier than late second or third pregnancies . A larger gap between pregnancies too seem too favor Down’s Syndrome.

Down Syndrome is the result of the genetic abnormality trisomy 21. Trisomy has been the focus of extensive medical research but the exact mechanism is still not understood. One feature common to most trisomies is an increase in frequency of trisomic pregnancies with increasing matern al age. There is strong evidence for uterine selection against genetically disadvantaged embryos. However, as women approach the menopause and the risk of future infertility increases, this selection, or filtering stringency, is expected to relax.

Neuh?user and Krackow’s paper provides evidence that older mothers, who give birth to children with Down Syndrome, have a relaxed stringency of quality control of embryos (or relaxed filtering stringency), which increases the probability that these women will bring children with developmental defects to full term. They believe that this relaxed filtering stringency is an adaptive maternal response and it might explain why the rate of Down Syndrome accelerates with increasing maternal age. These findings have important implications for the prevention of abnormal fetal development. The authors conclude that “clearly, identification of the relaxation control mechanisms and therapeutic restoration of a stringent screen holds promise not only for Down Syndrome.”

Source-Eurekaler
MTS
'"/>




Related medicine news :

1. Is Diabetes the Leading Cause of Kidney Failure in India
2. Antibiotics Dangerous for Diarrhoea in Children Caused by E.Coli
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Breast Cancer Surgery Causes Psychological problems
5. Arthritis Drug May Cause Liver Damage
6. Causes of weakness in the aged
7. Gene Mutation Causes Ovarian Failure
8. Does Radiation Cause Lung Cancer?
9. Chronic Diseases said to Cause Falls in the Elderly
10. Vision Loss Due To Diabetic Retinopathy a Major Cause Of Concern
11. Low Testosterone Levels the Cause Of Depression In Men
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along ... updates for the primary prevention of cardiovascular diseases during the 15th Annual ...
(Date:10/13/2017)... ... ... Apple Rehab Shelton Lakes , which specializes in the delivery of ... part of a disaster drill on October 3rd. , Apple Rehab participated with the ... as well as the Connecticut Long Term Care Mutual Aid Plan (LTC-MAP). The ...
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... will be giving viewers the lowdown on sciatica in a new episode of ... that focuses on current events and innovation and investigates each subject in-depth with ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... 12, 2017   Divoti USA will engrave ... the standard of the latest FDA requirements, which stipulates new criteria ... Anyone in need of Medical ID jewelry such as Medical ID ... are engraved in terms of the new FDA requirements . ... Divoti offers this dark mark ...
(Date:10/11/2017)... 11, 2017  Caris Life Sciences ® , a ... promise of precision medicine, today announced that St. Jude ... Oncology Alliance™ (POA) as its 17 th member. ... Jude Crosson Cancer Institute will help develop standards of ... tumor profiling, making cancer treatment more precise and effective. ...
(Date:10/10/2017)... COUNTY, Calif. , Oct. 10, 2017  NDS received FDA ... Mobile  — a medical-grade battery-powered display stand specifically designed for endoscopy ... to transform technology into a clinical solution to support the improvement ... Innovative Design ... ZeroWire Mobile Wireless Solution ...
Breaking Medicine Technology: