Navigation Links
Cataplexy During Status Cataplecticus Resembles REM Sleep

Cataplexy is a sudden temporary loss of muscle tone in the body, which occurs during times of intense emotional states like laughter or anger. Cataplexy is one of the symptoms of// narcolepsy, which is a compulsive disorder to fall asleep.

In narcolepsy there are compulsive sleep attacks and the person has an irresistible urge to sleep even in the most unlikely circumstances like driving.

A study has led to the discovery that cataplexy during status cataplecticus partially resembles normal rapid eye movement (REM) sleep but without the other imaging characteristics of this state.

The first efforts to identify the neural structures and pathways underlying cataplexy during status cataplecticus in a narcoleptic patient, with the use of brain perfusion single photon emission computed tomography (SPECT), have led to the discovery that cataplexy during status cataplecticus, a case of prolonged cataplexy, partially resembles normal rapid eye movement (REM) sleep but without the other imaging characteristics of this state, according to a study published in the February 1st issue of the journal SLEEP.

The study, conducted by Dorothée Chabas, MD, PhD, of Université Pierre et Marie Curie-Paris, and Assistance Publique H?pitaux de Paris, focused on a 68-year-old woman with hypocretin-deficient narcolepsy-cataplexy, who suffered status cataplecticus after having stopped clomipramine. The woman underwent a 99mTc-ethylcysteinate dimmer brain SPECT during an episode of cataplexy. This image was compared with her brain SPECT during an intervening asymptomatic period. Subtraction SPECT coregistered to magnetic resonance imaging (MRI)-determined anatomic areas differentially perfused during cataplexy and basal wakefulness state.

According to the results, the areas hyperactivated during cataplexy correspond on brain MRI with the cingular area, the left and right orbitofrontal cortex, the right temporal cortex and the right put amen, which are all activated during normal REM sleep. There was, however, no hyperactivation of the pons, amygdale or occipital cortex, other imaging characteristics of normal REM sleep.

"To my knowledge, this report is the first of imaging analysis comparing brain activation during a cataplectic episode with a nonsymptomatic state in the same subject," said Chabas. "Previous imaging studies have failed to show structural changes in the brain of narcoleptic patients, but functional changes could be demonstrated. The method used in this particular study analyzed functional features specifically related to the mechanisms of cataplexy. Picturing brain activity during cataplexy, a transient and unpredictable neurologic state, is challenging. It is, however, easier to study cataplexy during status cataplecticus."

The National Heart Lung and Blood Institute estimated that nearly three out of four people with narcolepsy also have cataplexy, a major symptom of narcolepsy, which is characterized by a sudden, bilateral loss of muscle tone (and possible fall) with preserved consciousness. It is usually triggered by emotions. Mild attacks of muscle weakness can cause: Head nodding Drooping eyelids Difficulty speaking Difficulty moving arms or hands or a weakened grip Buckling of the knees

Persons who think they might have a sleep disorder are advised to discuss the problem with their primary care physician, who will refer them to a sleep specialist.

Source-Eurekalert
PR
'"/>




Related medicine news :

1. Oxygen Usage During Exercise Could Indicate Heart Problems
2. Predicting The Risk Of Preeclampsia During Pregnancy
3. Drugs Taken During Pregnancy Found To Affect Unborn Babies
4. Alcohol Consumption During Pregnancy Not Safe
5. The Importance Of “ Good ”Control Of Diabetes During Pregnanc
6. The Effects Of Dental X-Rays During Pregnancy Questioned
7. The Use Of Antioxidants To Diminish Effects of Alcohol During Pregnancy Questioned
8. Oxygen Consumption During Workouts Could Indicate Heart Problems
9. Folic Acid Supplementation During Pregnancy Could Help Prevent Spina Bifida
10. Being Obese Increases Ones Risk Of A wrong Diagnosis During Medical Imaging
11. Avoiding Drugs During Pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... ... 2016 , ... EB Medicine presented its first-ever “Issue of ... in Ponte Vedra Beach, FL. The awards honor the outstanding work of leading ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the efforts ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic ... Frederick area economy by obtaining investment capital for emerging technology companies. SCP ... that have already resulted in more than a million dollars of capital investment ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, MTI-GlobalStem, a ... cells and other difficult to transfect cells, announces its launch of the PluriQ™ ... Gene Editing System is a complete system for culturing and transfecting human ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 The vast ... an outpatient dialysis facility.  Treatments are usually 3 times ... hours per visit, including travel time, equipment preparation and ... patient, but especially grueling for patients who are elderly ... a skilled nursing and rehabilitation centers for some duration ...
(Date:6/23/2016)... 2016  Experian Health, the healthcare industry ... patient payment and care experience, today announced ... and services that will enhance the breadth ... These award-winning solutions will enable healthcare professionals ... in an ever-changing environment and redefine front-office ...
(Date:6/23/2016)... 23, 2016  The National Pharmaceutical Council (NPC) ... health policy research organization as its newest member.  ... senior vice president and chief scientific officer, Mallinckrodt ... the NPC Board of Directors. ... has joined us in support of our efforts ...
Breaking Medicine Technology: