Navigation Links
Carriers With Alzheimer's High Risk Gene Type Age Normally Until the Disease Strikes

Researchers from Australia have come to the conclusion that a high risk genotype that raises the chances for Alzheimer's disease, does not add changes in the carrier//, pertaining to communication skills and memory during most of their adulthood. Those with the high risk gene seem to get affected by dementia, only much later in old age, along with other factors.

The study, has been described as the largest of its kind. This research unearthed that both carriers and non-carriers seem to age normally in the same pattern with similar decline in cognitive function over the years. Decades later, carriers show up with symtoms of aging that begin to snowball into pronounced symptoms of dementia. The findings imply that the genotype which promotes risk of developing this degenerative disorder plays a role much later. The findings are published in the January issue of Neuropsychology, by the American Psychological Association (APA).

The study may help rule out the possibility of very early Alzheimer's as the cause of the decline among carriers before they reach old age,write the authors, "[Alzheimer's disease] processes may occur later in the lifespan and add to normal cognitive aging to produce a dementia syndrome." The study confirmed that carriers of the APOE4 gene type (allele), which confers higher risk for Alzheimer's, are just like other people their age throughout most of adult life in terms of core mental functions. Previous findings had been unclear. Lead author Anthony Jorm, PhD, DSc, explains, "Although some areas of cognitive decline begin from early adulthood onwards, this is not due – as some have speculated -- to very early Alzheimer's changes in the brain."

The APOE gene helps to transport cholesterol through the production of apolipoprotein E. People carry two copies of APOE, each being one of four APOE alleles. APOE4 raises Alzheimer's risk. In this study, researchers at the University of Melbourne and Australian Nation al University assessed whether the small percentage (varying by ethnicity) of the population that carries at least one copy of APOE4 are cognitively different from non-carriers long before anyone shows signs of dementia.

The authors studied 6,560 people living in Canberra or neighboring Queanbeyan enrolled in the PATH Through Life Project, a long-term study of aging that assesses people in the age groups of 20-24, 40-44, and 60-64 years every four years for a period of 20 years. Jorm and his colleagues evaluated whether, in each age group, carriers of APOE4 (27 percent in their sample) were significantly different from non-carriers on tests of functions affected by Alzheimer's: episodic memory, working memory, mental speed, reaction time, and reading vocabulary.

Performance on all tests (except for reading vocabulary, which tends to hold up with age) declined across age groups, a sign of normal cognitive aging. However, APOE4 did not affect performance at any age. Thus the researchers conclude that at least between ages 20 and 64, people with APOE4 age normally in those central cognitive functions.

This finding suggests that APOE4 heightens the risk for Alzheimer's in old age through an additional, as-yet-unknown process that accelerates or intensifies normal changes, pushing them into the range of disease. Jorm provides an analogy. "In general, hair becomes thinner with age," he says. "However, there are some people who have an additional hereditary factor that makes them bald at an early age."

Source-Eurekalert
MST
'"/>




Related medicine news :

1. Alzheimer Gene Carriers Found To Have Memory Problems
2. Fruit Bats Act As Carriers of Ebola Virus
3. Financial Allowances Being Offered To Poor Vietnamese HIV Carriers
4. Coffee Reduces Risk of Breast Cancer in BRCA1 Mutation Carriers
5. HIV Carriers Join Hands to Fight for their Rights
6. HIV Carriers Form an Association to Fight Social Stigma in Jharkhand
7. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
8. Decrease in testosterone levels lead to Alzheimers
9. Smokers are prone to Alzheimers
10. Over-The-Counter Drugs May Prevent Alzheimers
11. Alzheimers followed by head injury
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
(Date:10/12/2017)... CA (PRWEB) , ... October 12, 2017 , ... ... Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent technology. ... a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can ...
(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics ... PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... of Morris F. Collen, a pioneer in the field of medical informatics, this prestigious ...
(Date:10/12/2017)... ... 12, 2017 , ... Information about the technology: , Otomagnetics ... enable prevention of a major side effect of chemotherapy in children. Cisplatin and ... For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... Ky. , Sept. 19, 2017   ZirMed Inc ... predictive analytics, today announced that it has been ranked #1 ... Black Book™ Rankings 2017 User Survey. ZirMed was ... solution for large hospitals and medical centers over 200 beds ... Black Book,s healthcare technology user survey history. ...
(Date:9/13/2017)... ATLANTA , Sept. 13, 2017   OrthoAtlanta ... to the Atlanta Football Host Committee (AFHC) for the 2018 ... Monday, Jan. 8, 2018, at Mercedes-Benz Stadium in ... part of the AFHC "I,m In" campaign, participating in many ... ...
(Date:9/12/2017)... 12, 2017  ValGenesis Inc., the global leader ... pleased to announce the appointment of Dr. ... Board of Directors and Chairman of Advisory Board ... science companies to manage their entire validation lifecycle ... in this process. Furthermore, ValGenesis VLMS enables rigorous ...
Breaking Medicine Technology: