Navigation Links
Carnitine deficiency in children and adolescents with type 1 diabetes

Carnitine is essential for the lipid and carbohydrate metabolism, and is known to increase the sensitivity of the cells to insulin.// The use of glucose by the peripheral tissues and proper metabolic control in Type 1 diabetes has potential impact on long-term complications.

In diabetes, the metabolism of carbohydrate and fat is abnormal and an association between the proper metabolic control and the development of complications is widely recognized. Decreased plasma carnitine levels have already been reported in patients with type 2 diabetes and an underestimated role of carnitine in the clinical course and the complications has been suggested.

The development of microvascular complications is uncommon during childhood and adolescence; however, the principles of proper metabolic control must be imparted from the onset. Recognition of carnitine deficiency in these patients may thus have therapeutic implications.

In a study published in vol 18 (5) of Journal of Diabetes and its Complications, researchers from the Department of Paediatrics, University of Crete, Greece investigated the carnitine levels in children and adolescents with Type 1 diabetes.

The plasma total, free, and acylcarnitine levels in 47 children and adolescents with type 1 diabetes were determined by a radioisotopic assay and compared to the values of a series of anthropometric measurements and metabolic parameters, including blood glycosylated hemoglobin Alc, serum cholesterol and triglycerides, and urine microalbumin levels.

The results from the study confirm the relative deficiency of total and free carnitine in children and adolescents with Type 1 diabetes. Furthermore, clear evidence is provided that this decrease is time related and that patients with long-standing Type 1 diabetes are prone to carnitine alterations. Larger studies are needed in order to draw firm conclusions and to explore a possible role, if any, of supplementary carnitine in the prevention of diabetic complications.

Medindia on Type-1 Diabetes: Diabetes is a group of diseases with one thing in common - a problem with insulin. The problem could be that your body doesn't make any insulin, doesn't make enough insulin or doesn't use insulin properly.

The type-1 diabetes is caused by the loss of insulin secreting beta-cell due to selective autoimmune destruction of the pancreatic beta cells. In this type exogenous insulin is required to prevent diabetic ketoacidosis.
'"/>




Related medicine news :

1. Teens vitamin D deficiency an epidemic
2. WHO hopes to wipe away Iodine deficiency diseases by 2005
3. Gene responsible for immune deficiency discovered
4. Iron deficiency found in children with prolonged bottle feeding
5. Incidence of iron deficiency reduced by nutrient enhanced cereal- rice
6. Sunny Side Up - Vitamin-D deficiency linked to Schizophrenia
7. Prostate cancer risk pronounced with selenium-protein deficiency
8. Gastric bypass can cause deficiency of Vitamin A
9. Vitamin B deficiency may lead to poor athletic performance
10. Gene Therapy for Hereditary Immunodeficiency Diseases
11. Starvation in pregnant women can cause heart disease to their children
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/30/2016)... ... November 30, 2016 , ... The Fertility Centers of ... a Cigna Infertility Center of Excellence. The Cigna Center of Excellence recognizes participating ... honor to be designated a Cigna Infertility Center of Excellence," said Fertility Centers ...
(Date:11/30/2016)... , ... November 30, 2016 , ... "I hate when ... arm while brushing my teeth," said an inventor from Bridgewater, N.J. "I thought that ... develop this handy device." , He developed the patent-pending DEFLECTOR to prevent saliva and ...
(Date:11/30/2016)... Palm Beach Gardens, FL (PRWEB) , ... November ... ... leader in eating disorder and mental health treatment has announced the opening of ... facility provides specialized partial hospitalization and intensive outpatient treatment for adults and adolescents, ...
(Date:11/30/2016)... ... November 30, 2016 , ... In ... been a focus of public policymakers and system stakeholders in many states. To ... its Medical Price Index for Workers’ Compensation, Eighth Edition (MPI-WC) . , ...
(Date:11/30/2016)... ... 2016 , ... The Clinical Data Interchange Standards Consortium (CDISC) ... goes into effect next month. Sponsors whose studies start after December 17, 2016 ... The current FDA Data Standards Catalog specifies the use of CDISC standards: ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... 2016 On Thursday, the NASDAQ Composite ... while the Dow Jones Industrial Average managed to stay in ... markets, which prompted Stock-callers this morning to look at the ... NUVA ), Smith & Nephew PLC (NYSE: ... and Cesca Therapeutics Inc. (NASDAQ: KOOL ). You ...
(Date:12/2/2016)... , Dec. 1, 2016  Today, Simpson Healthcare Executives, ... honor of being selected as winners of multiple awards ... Executives Website at the PLATINUM level, Blue Zones Menu ... at the GOLD Level, and our proprietary 3ConneX Platform ... Simpson Healthcare Executives, we are excited to showcase our ...
(Date:12/2/2016)... , Dec. 2, 2016 Allergan plc (NYSE: ... provided additional information on its previously announced Accelerated Share Repurchase ... ... As previously announced, the Company entered ... under which the Company will repurchase $10 billion of its ...
Breaking Medicine Technology: