Navigation Links
Cannabinoids Regulate Inflammation Process

Endocannabinoids produced in human body have anti-inflammatory effect. Scientists from the University of Bonn have discovered this in experiments on mice. The study may also have implications for therapy. In animal experiments, a solution with an important component made from cannabis reduced allergic reactions of the skin.

Extracts of the hemp plant cannabis are traditionally used as a popular remedy against inflammation. At the beginning of the last century this natural remedy was even available at every chemists. But due to the intoxicating effect of the component THC (tetrahydrocannabinol) the plant was taken off the chemists shelves in the 1930s.

THC acts on the cannabinoid receptors, of which there are two types, CB1 and CB2. Both receptors are made such that THC can attach itself to them. In the brain this causes the intoxicating effect of hashish, cannabis and marijuana. But why does the body have CB1 and CB2 anyway" For two decades it has been known that the human body also produces its own cannabinoids.

Like THC they can attach themselves to the receptors. The brain scientist Professor Andreas Zimmer from the Bonn Institute of Molecular Psychiatry is investigating what the function of this endocannabinoid system is. Mice without CB1 receptors show psychological abnormalities, he explains. By contrast, CB2 regulates the growth of bones, for example.

Coincidence However, according to these most recent results, endocannabinoids also seem to play an important part in regulating inflammation processes. As is often the case with important discoveries, coincidence was involved. In scientific experiments mice are given an ear clip, so that researchers can tell them apart. In most cases the mice can handle this without problems, Dr. Meliha Karsak, a member of Professor Zimmers team, explains.

With our mice this was different. The skin around the ear clips became inflamed. There are genetically modified s trains of mice in which both cannabinoid receptors are dysfunctional. And it was in precisely these strains that the inflammation occurred,' she explains.

Together with the Bonn dermatologists Dr. Evelyn Gaffal and Professor Thomas Tting the researchers investigated these findings. Skin rash can be caused by allergens in laboratory mice. 'However, normally these rashes are only minor,' Dr. Gaffal emphasises. 'However, strains of mice in which the cannabinoid receptors are missing react much more intensely. We observed something similar when we blocked the receptors with medication.'

Step on the brakes When inflammation occurs the endocannabinoids act like someone stepping on the brakes. They prevent the body from doing too much of a good thing and the immune reaction from getting out of control. This is consistent with the fact that at the beginning of the infection the endocannabinoid concentration increased in the mice.

'Apart from that there are strains of mice in which the breakdown of these active substances produced by the body is malfunctioning,' Evelyn Gaffal says. 'They have an increased endocannabinoid concen-tration in their skin. In our experiments these animals also showed a less marked allergic reaction.'

The results open up new options for the treatment of skin allergies and inflammation. Firstly, drugs which prevent the breakdown of endocannabin-oids look promising. But the old household remedy cannabis could also make a comeback as an ointment. In the experiment on mice this approach has already been successful.

'If we dabbed THC solution on to the animals' skin shortly before and after applying the allergen, a lot less swelling occurred than normal,' Professor Thomas explains. 'THC attaches itself to cannabin-oid receptors and activates them. In this way the active substance reduces the allergic reaction.' Incidentally, ointment like this would probably not have an intoxicating effect, for this the amount of THC contained would be much too small.


'"/>




Related medicine news :

1. Cannabinoids drug for inflammatory bowel
2. Cannabinoids - Antidepressant And Inflammatory Bowel Disease Treatment
3. Brain Enzyme Found To Regulate Weight
4. Chemical Signaling Helps Regulate Sensory Map Formation In The Brain
5. Researchers Purify Protein That Could Regulate Male Hormones
6. Ayurveda Massage Centres in Kerala to be Regulated
7. A Protein In Brain Regulates Anxiety And The Consumption Of Alcohol
8. Study States That CNS Could Regulate Arthritis
9. Gene May Regulate Cellular Aging
10. Gene Involved In Common Birth Defect Also Regulates Skin Biology
11. A New System To Regulate Use Of Chemicals
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... , ... October 13, 2017 , ... ... throughout Arkansas that offers insurance and financial preparation services, is providing an update ... City Rescue organization. , Rock City Rescue is a locally recognized nonprofit that ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... established the certification process to promote standards of excellence for the field of ... scheduled for March 22 – 25, 2018 in Orlando, Florida at the Omni ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes ... a mock evacuation of the facility as part of a disaster drill on October ... Hose EMS and Shelton City Emergency Manager, as well as the Connecticut Long ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... COUNTY, Calif. , Oct. 10, 2017  NDS received FDA ... Mobile  — a medical-grade battery-powered display stand specifically designed for endoscopy ... to transform technology into a clinical solution to support the improvement ... Innovative Design ... ZeroWire Mobile Wireless Solution ...
(Date:10/5/2017)... , Oct. 5, 2017  In response to ... Oral and Maxillofacial Surgeons (AAOMS) released prescribing recommendations ... to be used as a first-line therapy to ... Recognizing the value ... White Paper "Opioid Prescribing: Acute and Postoperative Pain ...
(Date:10/4/2017)... OBP Medical , a leading ... today announced regulatory approval from Brazil,s ... Nacional de Vigilância Sanitária (ANVISA)) to market ... with integrated LED light source and smoke evacuation ... of a tissue pocket or cavity during surgical ...
Breaking Medicine Technology: