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Cancer-Killing Viruses Employ Multiple Mechanisms

did not suffer the same fate as cancer cells. In fact, infection actually stimulated the cells to a higher level of cancer-fighting immune activation, as well as priming the cancer-killing ability of natural killer cells and T cells.

These experiments indicate that in addition to killing cancer cells by invading them, the reovirus may support early, innate anti-tumor immunity as well as longer-lasting adaptive immunity against cancer. Discovery of the “immune connection” has lead to a more complete picture of how oncolytic viruses kill cancer cells. If scientists can enhance the anti-tumor immune response, they may be able to make reovirus therapy more effective.

“These results are exciting as they suggest that in addition to directly killing cancer cells in the short term, the reovirus imparts an important cancer-killing ability to the body’s own immune system,” said Dr. Coffey.



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