Navigation Links
Cancer-Killing Compound From A Fungus

A cancer-killing compound called rasfonin has been synthesized from a fungus for the first time. This fungus was discovered the walls of a New Zealand cave cave. //A chemical found in this fungus causes the cancer cells to commit suicide while not harming healthy cells.

"In 2000, scientists in Japan discovered that this compound might have some tremendous potential as a prototype anticancer agent, but no one has been able to study or develop it because it's so hard to get enough of it from natural sources," says Robert K. Boeckman, professor of chemistry.

"You either grow the fungus that makes it, or you go through a complicated chemical synthesis process that still yields only a minute amount," he says. "Now, after five years of effort, we've worked out a process that lets researchers finally produce enough rasfonin to really start investigating how it functions, and how we might harness it to fight cancer."

In 2000, researchers from Chiba University in Japan and the University of Tokyo simultaneously discovered a compound in certain fungi that selectively destroyed cells depending upon a gene called ras--one of the first known cancer-causing genes. They had found rasfonin, a compound that seemed tailor-made to knock out ras-dependent cancers like pancreatic cancer.

After six years, however, rasfonin's secrets remain a mystery because researchers can't make enough of it to carry out tests.

To bring about a new drug, organic chemists must produce a new chemical in enough quantity to test it under many different circumstances to tease out its modus operandi. Until now, no method existed to generate rasfonin, aside from growing more fungus--a time-consuming and terribly inefficient method. Boeckman, the Marshall D. Gates, Jr. Professor of Chemistry at the University of Rochester, has now revealed a process that produces 67 times more rasfonin than any previous method. For the first time, scientists can obtain enough rasfonin to conduct proper biological tests on it.

"At a guess, I'd say that rasfonin itself will not be the final compound that might come to market," says Boeckman. "But we need to figure out how it works, how it triggers the cancer cell to shut itself down. The key is to find exactly what buttons rasfonin is pushing, and then figure out if there's a way we can safely and more simply push those same buttons. But we couldn't do that until we have enough to test."

Even Boeckman's simplified process is notably complex, employing sophisticated organic reactions. Instead of the original method's 23 steps, Boeckman's has just 16--but finding them took five years of his team's hard work, skill and intuition.

Boeckman's paper, published in the Aug. 30 issue of the Journal of the American Chemical Society, outlines the sequence of steps showing how Boeckman's group inserted, removed, or altered the three-dimensional and chemical structure of their compound until they produced complete rasfonin. Diagrams of the complete process are available on the Web at pubs.acs.org.

"Very soon, researchers should be able to scale up this process rather easily to whatever volume they need," says Boeckman. "It may be a long road to a possible treatment, but at least we're now past the first hurdle."

(Source: Eurekalert)
'"/>




Related medicine news :

1. Cancer-Killing Viruses Employ Multiple Mechanisms
2. Compound of Broccoli combats breast cancer
3. New Compound Could Strengthen The Effect Of Chemotherapy
4. Breathing Cancer Causing Compounds During Pregnancy Found To Affect Offspring
5. Compound from cottonseed for neck and head cancers
6. Compounds Found In The Vegetable Broccoli Could Have Anti-Cancer Properties
7. Adding Sorghum Compounds To Dietary Supplements May Help Lower Cholesterol
8. Compound In Grapes And Red Wine To Counter Alzheimers Disease
9. Sugars Could Contain Key Cancer Inhibiting Compounds
10. Compound From Cyanobacterium Can Fight Alzheimer’
11. Five New Anti-Inflammatory Compounds Produced By Indian Scientists
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... The ... national conference convening academic faculty engaged in or interested in palliative care education and ... will be held in North County San Diego on Sept. 28 and 29, ...
(Date:2/24/2017)... Farifax, VA (PRWEB) , ... February 24, 2017 , ... ... winners for excellence in radiology marketing programs at the annual Building Better ... the Worthington Renaissance Fort Worth Hotel in Fort Worth, Texas. Nine awards are given ...
(Date:2/23/2017)... , ... February 23, 2017 , ... ... official 2017 partnership with The Jensie Gran Fondo of Marin. For the second ... rays with Thinksport’s broad-spectrum, mineral-based sunscreen. , “We are thrilled to provide our ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rare Disease ... will be participating in Rare Disease Day events, hosted by the Rare Disease ... Disease Report, a website, weekly e-newsletter and quarterly publication, will be conducting interviews ...
(Date:2/23/2017)... ... February 23, 2017 , ... Rosica Communications, a ... content marketing, social media management, corporate communications, SEO and cause marketing, is opening ... in nearby New Hampshire, Massachusetts and Canada, Rosica will focus on expanding its ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Following receiving CE Marking in Europe ... AMAR is a major milestone for the country where the device was developed ... market in Israel   ... inclusion in the National Health Basket , Israel , ... E-QURE Corp. (OTCQB: EQUR), a leader in medical devices for the treatment of advanced wound ...
(Date:2/24/2017)... Research and Markets has announced the addition of the ... their offering. ... research Dry eye Drugs Price Analysis and Strategies - 2016, provides drug ... research answers the following questions: What are ... are they positioned in the Global Dry eye market? ...
(Date:2/24/2017)... Feb. 23, 2017 The U.S. Food ... PhenoTest BC Kit, performed on the Pheno System. ... that cause bloodstream infections and provide information about ... to (antibiotic sensitivity). The test also reduces the ... important information, which can guide antibiotic treatment recommendations ...
Breaking Medicine Technology: