Navigation Links
Cancer Gene Mutations Not Uncommon in General Population

Cancer gene mutations are found in about one percent of the total general population, occurring more frequently than previously thought, and may be associated with various// types of cancers, according to researchers at Yale School of Medicine.

Published in the December 6 Journal of the National Cancer Institute (JNCI), the study looked for the presence and rate of BRCA 1 and BRCA 2 mutations in a population of women with newly diagnosed ovarian cancer. They screened not only for the most common mutations but also for variants that may be more rare or difficult to distinguish. They then calculated the incidence of those variants in the general population and in individuals with family members who have had cancer.

Previous research has shown that lifetime risks for breast, ovarian and other cancers are elevated for people carrying the BRCA1/2 mutations. The Yale team found that the lifetime risk to age 80 is not the same for all mutations and some mutations have higher and some lower risks for developing cancers.

“The exact nature of the level of risk for the particular mutations needs to be further explored,” said lead researcher Harvey Risch, M.D., professor in the Division of Chronic Disease Epidemiology in the Department of Epidemiology and Public Health at Yale School of Medicine. “This study is an important first step in that direction.”

Risch and his co-authors screened 1,171 women in Ontario, Canada with ovarian cancer and assessed their risk of cancer based on whether or not they carried a mutation. The women were then asked about cancers among their 8,680 first-degree relatives—their parents, siblings and children.

“We found that cancer risk differed for each gene according to the mutation’s position in the gene,” said Risch, who is also a member of the Yale Cancer Center. “When choosing which individuals to screen for mutations, we should consider all kinds of cancers among family members, not jus t breast and ovary and not just cancers in females.”

Risch and his team will follow up the study with a larger population sample in order to better understand the individual mutations and their differences.

Source-Yale Universiy
SRM
'"/>




Related medicine news :

1. Fibroids unlikely to Turn Cancerous
2. Virus Level could Predict Cervical Cancer Risk
3. Cancer Doctors Okays Controversial Prostate Therapy
4. Potential New Cancer Gene Identified
5. Consensus on "Combination Therapy" for Breast Cancer
6. Cancers of Colon & Rectum linked to Cigarette Smoking
7. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
8. The Cancer Rumour mill working over time
9. Cancer drugs in development nearly doubled since 1995
10. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
11. Cancer patients turning to Internet for information
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... There was a time when tampons and ... going with the flow and turning to menstrual cups, like Lunette . To make ... is introducing their new anthem in this catchy video ! , It’s easy ...
(Date:5/25/2016)... ... 25, 2016 , ... Dr. Travis Schwarz is an experienced dentist who leads ... MO 63366. He serves patients of all ages with a full menu of dental ... is reflected in the superior patient reviews that he has consistently earned during his ...
(Date:5/25/2016)... , ... May 25, 2016 , ... ... services and products in the developing world, is pleased to release their 2015 ... over 5 million unwanted pregnancies, almost 14,000 maternal deaths and 3.8 million unsafe ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... its annual Medical and Prescription Drug survey , an employee benefits ... survey, which was conducted in December 2015, indicates that employers are turning to ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... "FCPX LUT ... quality of your footage," said Christina Austin - CEO of Pixel Film Studios. ... can quickly and easily add stylish color grades to their footage. A LUT is ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... Deutschland und GERMANTOWN, Maryland , ... Zusammenarbeit mit Therawis bedient dringenden ...   QIAGEN N.V. (NASDAQ: ... bekannt, eine Lizenz- und Entwicklungsvereinbarung mit Therawis Diagnostics ... die Onkologie eingegangen zu sein. Ein erstes Projekt ...
(Date:5/25/2016)... 2016  Zymo Research Corp. announced today the ... materials that help researchers obtain the most accurate ... The rapid growth of the study of microbiomes ... standard methods to improve the reproducibility and quality ... at every step of the measurement process including ...
(Date:5/25/2016)... , May 25, 2016 ... Size, Share, Development, Growth and Demand Forecast to 2022 ... Insulin Pump and Others)" published by P&S Market Research, ... $9,998.3 million in 2015, and it is expected to ... on type, the insulin pump segment is expected to ...
Breaking Medicine Technology: