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Cancer Drug Induces HDAC Inhibitor and Enhance Long-term Memory

HDAC inhibitor to enhance memory, we need to administer the drug during this critical period when gene expression is required.,he added.

Wood and his colleagues discovered that the protein CBP must be present for HDAC inhibitors to improve memory,When tested in mice genetically engineered without CBP, the HDAC inhibitors did not improve memory. When CBP is blocked in humans, it can lead to neurodegeneration associated with Huntingtons disease and cognitive deficits in Rubenstein-Taybi syndrome. HDAC inhibitors may help overcome that blockage and lead to better neural function in people with those disorders and perhaps improve memory as well.


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