Navigation Links
Cancer Cells Trigger Supporting Cells to Turn Cancerous

With the fight against cancer focusing at the molecular and genetic levels, the role played by the surrounding non-cancerous cells is coming under increasing scrutiny.// Now scientists at the University of North Carolina at Chapel Hill have demonstrated that these supporting cells are indeed key players in the ultimate development and aggressiveness of cancer.

These findings were arrived at after studying a genetically engineered mouse model of prostate cancer. The researchers also accelerated the development of the cancer in the tumor cells. This rapid rate caused a change in the fibroblasts in the surrounding cells. These fibroblasts, which are connective tissue cells, began to proliferate rapidly. Eventually these fibroblasts lost the protective action of the tumor suppressor, p53. This meant that the cells continued to merrily divide thereby evolving as cancer cells. "This occurred in 100 percent of the animals studied. It's a strong selective pressure," said Dr. Terry Van Dyke, professor of genetics and biochemistry and biophysics in the School of Medicine, member of the UNC Lineberger Comprehensive Cancer Center and lead author of the study. "Now the whole organ is evolving as a cancer, not just a single population of cells." Van Dyke added that the interaction between the predominant cancer cell and the surrounding cells played a key role in the development of the cancer. "Think of it as a microcosm of evolution, such that every change that goes on in the cancer cell can impact cells around it. It's a back-and-forth cross-talk via which the whole entity evolves, not just a subset of cells within the cancer. It's an environment where changes in the surrounding cells are selected that will help tumor growth."

Although the study has no immediate implication in the fight against cancer, it does provide valuable insights into what goes on in the supporting cells. Future anti-cancer therapies can be evolved after taking these interactions int o consideration. The findings of the UNC team are published in the December 16 issue of the journal Cell. Graduate student Reginald Hill and postdoctoral researcher Dr. Yurong Song. Dr. Robert D. Cardiff, professor of pathology at the University of California at Davis, also collaborated in the study.

Contact: L.H. Lang 919-843-9687 University of North Carolina School of Medicine

Related medicine news :

1. Fibroids unlikely to Turn Cancerous
2. Virus Level could Predict Cervical Cancer Risk
3. Cancer Doctors Okays Controversial Prostate Therapy
4. Potential New Cancer Gene Identified
5. Consensus on "Combination Therapy" for Breast Cancer
6. Cancers of Colon & Rectum linked to Cigarette Smoking
7. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
8. The Cancer Rumour mill working over time
9. Cancer drugs in development nearly doubled since 1995
10. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
11. Cancer patients turning to Internet for information
Post Your Comments:

(Date:6/24/2016)... ... , ... Marcy was in a crisis. Her son James, eight, was out of control. Prone ... physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If ... at my other children and say he was going to kill them. If we ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon and the ... in the world, and the most handsome men, look naturally attractive. Plastic surgery ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Story Highlights: ... the health care industry is causing providers to review ... Deloitte offers a suite of solutions for health care ... cost optimization: labor resource analysis, revenue cycle optimization and ... outcomes and better economics ...
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
Breaking Medicine Technology: