Navigation Links
Cancer Cells Reprogram Energy Needs To Grow And Spread

Studying a rare inherited syndrome, researchers at Johns Hopkins have found that cancer cells can reprogram themselves to turn down their own energy-making machinery and use less oxygen, and that these changes might help cancer cells survive and spread.

The Hopkins scientists report that the loss of a single gene in kidney cancer cells causes them to stop making mitochondria, the tiny powerhouses of the cell that consume oxygen to generate energy.

Instead, the cancer cells use the less efficient process of fermentation, which generates less energy but does not require oxygen. As a result, the cancer cells must take in large amounts of glucose. The appetite of cancer cells for glucose is so great that it can be used to identify small groups of tumor cells that have spread throughout the body.

Although changes in mitochondria have been described in many cancers, the Hopkins study shows for the first time how a cancer-causing mutation can block their production.

There must be a strong advantage to cancer cells to stop using a highly efficient process in favor of one that generates much less energy, says Gregg Semenza, M.D., Ph.D., professor of pediatrics and director of the vascular biology program in the Institute for Cell Engineering at Johns Hopkins.

But turning down the thermostat in a sense, may give the cancer cell a survival edge. Reporting in the May 8 issue of Cancer Cell, Semenza and his colleagues found that if they reversed the switch and forced kidney cancer cells to start making mitochondria again, the cells produced increased amounts of free radicals, which can cause cells to stop dividing or even die.

Semenzas team uncovered the mitochondrial mechanism in a study of Von Hippel-Lindau (VHL) syndrome, caused by a single gene mutation and characterized by the tendency to develop tumors in many parts of the body, including the kidney, brain and adrenal glands.

Semenza and colleagues measured mitochondria content and oxygen use in kidney cancer cells that contain no VHL protein and in the same cells with VHL engineered back in. Restoring VHL caused the cells to make two to three times more mitochondria and use two to three times more oxygen.

VHL normally blocks the action of HIF-1, a protein that the Hopkins group discovered in 1992. Cells normally make HIF-1 only under low oxygen conditions, when fermentation is necessary to make energy. However, in the absence of VHL, HIF-1 is active even when oxygen is plentiful and switches on genes that help a cell take up more glucose.

This current work shows that excess HIF-1 counteracts a protein called MYC, which normally stimulates cells to make mitochondria. Because MYC is turned on in many other cancers, these results suggest that shutting down the mitochondria must be a very important event in kidney cancer, Semenza notes.

There is currently no treatment available for patients with advanced kidney cancer. Scientists at pharmaceutical companies, the National Cancer Institute, and laboratories at Hopkins and other universities are investigating whether drugs that inhibit HIF-1 may be useful for cancer therapy.


'"/>




Related medicine news :

1. Fibroids unlikely to Turn Cancerous
2. Virus Level could Predict Cervical Cancer Risk
3. Cancer Doctors Okays Controversial Prostate Therapy
4. Potential New Cancer Gene Identified
5. Consensus on "Combination Therapy" for Breast Cancer
6. Cancers of Colon & Rectum linked to Cigarette Smoking
7. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
8. The Cancer Rumour mill working over time
9. Cancer drugs in development nearly doubled since 1995
10. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
11. Cancer patients turning to Internet for information
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... ... , ... 21 Middle East and South Asia Leaders Selected as Eisenhower Fellows ... and civil society in 11 countries across the Middle East and South Asia to ... exchange of knowledge and ideas with the leading minds in their fields. , ...
(Date:6/23/2017)... ... 23, 2017 , ... PureLife Dental is pleased to announce that California Dental ... As part of the amalgam separator endorsement, all CDA members may purchase an ECO ... the retail value. This partnership between PureLife and CDA is especially timely as it ...
(Date:6/23/2017)... ... June 23, 2017 , ... American Farmer, will feature Chr. ... is slated to air fourth quarter 2017. American Farmer airs Tuesdays at 8:30aET on ... Danish pharmacist, founded Chr. Hansen in Denmark in 1874 after a groundbreaking discovery of ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... management, financial planning, and related services to families and business owners in and ... charity drive to benefit senior citizens in the area. , Meals on Wheels ...
(Date:6/23/2017)... ... , ... All-Star Insurance, a family managed agency that offers insurance management assistance ... the launch of a new charity drive to benefit women in the area diagnosed ... that an estimated 252, 710 new cases of invasive or high risk breast cancer ...
Breaking Medicine News(10 mins):
(Date:6/2/2017)... LAWRENCE, Mass. , June 2, 2017  NxStage ... advancing renal care, today announced new findings demonstrating positive ... NxStage ® System One™. The data will be ... 2017, in Madrid, Spain . ... Knowledge to Improve Home Dialysis Network in ...
(Date:5/29/2017)... TEL AVIV, Israel, May 29, 2017  Cellect Biotechnology ... of innovative technology which enables the functional selection of ... financial results for the first quarter ended March 31 ... pleased with our accomplishments in the first quarter of ... the first quarter, we announced the treatment of the ...
(Date:5/22/2017)... , May 22, 2017  Lilac Corp, ... Gene-Eden-VIR/Novirin, announces the launch of a new ... the results of a clinical study that showed ... treatment with Gene-Eden-VIR/Novirin in individuals suffering from HPV ... note that there are no other treatments that ...
Breaking Medicine Technology: