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Cancer Cells Forming Blood Vessels Send Their Copper to the Edge

rcept vital copper being translocated outside of the cell during angiogenesis, the process stops, preventing growth of the tumor.”

The implications of the research do not end with the effect on angiogenesis. The dynamics of cellular copper this study revealed also have broad implications on the regulation of the metal ion content in metal-binding proteins. If such dramatic changes in where cellular copper is stored and used can happen so rapidly during angiogenesis, then the interactions of metal ions, such as copper, with the proteins and macromolecules that bind them in the cell must have very fluid dynamics themselves.

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