Navigation Links
Caloric Restriction in Non-obese People Extends Life Span

Caloric Restriction in non-obese people too is not without benefits. Caloric Restriction causes less oxidative damage in muscle cells which delays// aging and extends life span.

This new study was conducted by Anthony Civitarese, Eric Ravussin, and colleagues (Pennington Biomedical Research Center).Oxidative damage has been linked to aging, and this could explain how limiting calorie intake without malnutrition extends life span.

A calorie-restricted diet provides all the nutrients necessary for a healthy life but minimizes the energy (calories) supplied in the diet. This type of diet increases the life span of mice and delays the onset of age-related chronic diseases such as cancers, heart disease, and stroke in rodents. There are also hints that people who eat a calorie-restricted diet might live longer than those who overeat. In addition, calorie-restricted diets beneficially affect several biomarkers of aging, including decreased insulin sensitivity (a precursor to diabetes).

But how might caloric restriction slow aging? A major factor in the age-related decline of bodily functions is the accumulation of "oxidative damage" in the body's proteins, fats, and DNA. Oxidants—in particular, chemicals called "free radicals"—are produced when food is converted to energy by cellular structures called mitochondria. One theory for h ow caloric restriction slows aging is that it lowers free-radical production by inducing the formation of efficient mitochondria.

Civitarese and colleagues enrolled 36 healthy overweight but non-obese young people into their study. A third of them received 100% of their energy requirements in their diet; the caloric restriction (CR) group had their calorie intake reduced by 25%; and the caloric restriction plus exercise (CREX) group had their calorie intake reduced by 12.5% and their energy expenditure increased by 12.5%.

The researchers found that a 25% caloric deficit for 6 months, a chieved by diet alone or by diet plus exercise, decreased 24hr whole body energy expenditure (i.e. overall calories burned), which suggests improved mitochondrial function. Their analysis of genes involved in mitochondria formation indicated that CR and CREX both increased the number of mitochondria in muscle. Both interventions also reduced the amount of DNA damage—a marker of oxidative stress—in the participants' muscles.

The researchers also examined gene expression in the study participants. In yeast, worms, and flies the activation of the Sir2 gene increases life span and regulates cellular metabolism. An important question is whether caloric restriction can regulate SIRT1 (the mammalian equivalent of Sir2) in humans. Civitarese and colleagues found that indeed fewer calories can improve whole body metabolism in conjunction with an increase in SIRT1 gene expression in skeletal muscle. These results raise the possibility that SIRT1 may contribute to more efficient metabolism, less oxidative stress, and increase longevity in humans as it does in lower organism.

The results suggest that even short-term caloric restriction can produce beneficial physiological changes leading to improved health. Whether caloric restriction and the associated health benefits can be sustained over longer term remains to be established in humans.

Source-Eurekalert
RI
'"/>




Related medicine news :

1. Progression Of ALS May Be Prevented By A High Caloric Diet
2. FDA Imposes New Restrictions On Roches Accutane
3. Drink till you drop dead in English Pubs- Restriction on Timings Lifted
4. Bird Flu Restrictions To Be Lifted In Scotland
5. Restriction of Carbohydrates to Prevent Alzheimers Disease
6. No More Dietary Restriction for Heartburn Patients - Study Says
7. Liberated British Mothers Want No Restriction on Breast Feeding In Public
8. Restrictions Imposed on Sale of Edible Common Salt
9. Bush Supports Restriction to ‘Morning–After’ Pll
10. Calorie Restriction May Prevent, Reduce Alzheimer’s Neuropatholog
11. Gene Responsible for Ageing Process Discovered – and Calorie Restriction Could Hel
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... Aliso Viejo, California (PRWEB) , ... June 27, 2016 , ... ... that are fully customizable inside of Final Cut Pro X," said Christina Austin - ... with another unique style. Final Cut Pro X users can now reveal ...
(Date:6/27/2016)... Overland Park, KS (PRWEB) , ... June 27, 2016 , ... ... leader in retailers of Eyeglasses . , Millions of individuals in the United ... life, eyeglasses have become a way to both correct vision and make a fashion ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: ... and sells medical devices and wearable sleep respiratory products ... cooperation agreement with Hongyuan Supply Chain Management Co., Ltd. ... 20, 2016, to develop Dehaier,s new Internet medical technology ... will leverage Hongyuan Supply Chain,s sales platform to reach ...
Breaking Medicine Technology: