Navigation Links
Calcium Receptor Vital For Stem Cell Migration to Bone Marrow

A new discovery of a dictator molecule that governs the migration of blood stem cells to the bone marrow, resulting in subsequent production of blood cell components and immune stem cells could // hold the key to the development of more effective stem cell therapy for malignant and non-malignant conditions in the future.

"This is another remarkable example of how bone and bone marrow interact. A receptor known to participate in the body's regulation of calcium and bone also is critical for stem cells to engraft in the bone marrow and regenerate blood and immune cells", said David Scadden, one of the senior researchers.

"It reminds us how tissues interact and how looking closely at where stem cells reside may tell us a lot about how to manipulate them", he added. Bone marrow transplantation is a life saving treatment option for a number of people suffering from hematological malignancies and other condition such as sickle cell anemia and thalassemia.

The hematopoietic stem cells that have a remarkable regenerative capacity play a very critical role in the production of blood cell components such as the red blood cell, white blood cell and platelets. It also governs the production of various cellular components of the immune system. More than 10 million of these cells are being produced everyday.

The success of bone marrow transplantation lies in the direction of the obtained stem cells from the donor (through bone marrow aspiration) to a specific region such as the brain or bone marrow to induce renewal and recovery. The stem cell preparation is usually administered in the form of an intravenous infusion.

The stem cells are usually found in the peripheral layer, close to the inner surface of the bone, within the bone marrow cavity. Previous studies had already established that the stem cells are regulated by the adjacent bone forming cells (osteoblasts) to some degree. Hence it is quite probable that factors that influence bone formation could play a role in the migration of blood stem cells to the bone marrow.

Based on this assumption, the researchers analyzed the effects of a calcium receptor (CaR, necessary for absorption of extracellular calcium and bone growth) on stem cell migration. Studies conducted on transgenic animal models found out that the receptor played a very crucial role in the blood stem cell migration as expected.

Transgenic mice that had deficient CaR receptors had low levels of blood stem cells. This observation was only seen in CaR receptor, proving the potential role played by these molecules in migration of stem cells. The production of stem cells by the fetal liver was found to be independent of the absence of the calcium receptor. Furthermore, mice with reduced levels of the Car receptor were found to have a poor adherence to collagen I, a bone specific protein conducted by osteoblasts.

"Since there are already drugs available that target this receptor, we may be able to quickly adapt these findings in animals to the treatment of human patients", concluded Dr. Scadden.


'"/>




Related medicine news :

1. Dangers of Low Calcium Intake
2. Calcium reduces colon cancer risk
3. Calcium-blocker delays atherosclerosis than beta-blockers
4. Can Calcium Help Reduce Weight?
5. The Role Of Calcium In The Formation Of Kidney Stones
6. The Role Of Calcium In The Formation Of Kidney Stones
7. The Role Of Calcium In The Formation Of Kidney Stones
8. The Benefits Of Calcium Supplements
9. Calcium-rich Diet Good For Youngsters
10. Calcium and Vitamin D Supplements Could Be Effective In Treating Patients With Osteoporosis
11. Calcium and Vitamin D reduces risk of Premenstrual syndrome
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/9/2016)... ... , ... "I have gout, and I wanted to treat it naturally," said ... to relieve gout and pain caused by varicose veins. I drank it every morning ... relieved what VA doctors called the worst sinusitis case they'd seen and relieved gas, ...
(Date:12/9/2016)... ... December 09, 2016 , ... The Holy Name Medical Center ... NY, on December 3rd, to benefit Holy Name Medical Center's programs and services. ... raised over $1 million - the largest event in the Center's history, both ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... by the Undersea and Hyperbaric Medical Society (UHMS), the leading authority in hyperbaric ... patient safety. Only a few hospitals and facilities have earned this distinction. This ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... Therapy Management (MTM), adherence, and other pharmacist-delivered patient care services, has announced the ... and Eric Hoessel to vice president of sales. , Litsinger joined Mirixa ...
(Date:12/8/2016)... ... 08, 2016 , ... SunView Software aims to redefine IT ... both engaging and easy to use. Coming off the heels of a successful ... its plans to roll out new AI-powered self-service enhancements to help organizations implement ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... 9, 2016 Research and Markets has ... report to their offering. ... The report forecasts the global optical transceiver market ... The report covers the present scenario and the ... calculate the market size, the report considers the revenue generated from ...
(Date:12/9/2016)... aTyr Pharma, Inc. (Nasdaq: LIFE ), a biotherapeutics company ... severe, rare diseases, today announced that senior management will participate in ... Conference at the InterContinental Barclay Hotel in New York ... ET. About aTyr Pharma ... aTyr Pharma is engaged in the ...
(Date:12/9/2016)... Bermuda , Dec. 9, 2016  Axovant ... leading clinical-stage biopharmaceutical company focused on the treatment ... the data from a Phase 2b trial evaluating ... care donepezil, compared with donepezil plus placebo in ... that the addition of intepirdine to treatment was ...
Breaking Medicine Technology: