Navigation Links
CT Imaging With Novel Contrast Agent May Predict Heart Attack in Waiting

A new imaging technology may hold the key to not only stopping heart attacks in their tracks but also preventing them for ever occurring//. Researchers at Mount Sinai School of Medicine have shown the use computed tomography (CT) imaging along with a novel contrast agent know as N1177 can detect dangerous, high-risk plaque which cause heart attack and stroke. The findings may help physicians diagnosis a heart attack before the attack occurs.

High-risk plaque is characterized by their cellular and biologic structure. High-risk plaque rich in macrophages or cells can rupture, eventually causing a heart attack or stroke. Early identification of high-risk plaque in coronary arteries may be useful to prevent cardiac events but one major hurdle in detecting high-risk plaque is the lack of an imaging modality that allows physicians to see the composition of dangerous plaque, explains study author Zahi A. Fayad, PhD, FAHA, FACC, Professor of Radiology and Medicine (Cardiology) and director of the Translational and Molecular Imaging Institute at Mount Sinai School of Medicine. “Coronary CT imaging has advanced the diagnosis and prognosis of heart disease,” says Dr. Fayad. “But, what if we had the opportunity to prevent a heart attack from happening? This modality may allow us to do just that.”

A team of researchers led by Dr. Fayad tested an iodinated nanoparticulate contrast agent called N1177 for the detection of macrophages in an animal model with 64-slice CT. High-risk plaque in this animal model contained high levels of macrophages which are similar in size and content to human coronary plaques. Researchers compared the enhancement of macrophage rich plaque after the injection of N1177 and a conventional CT contrast agent. The enhancement of the macrophage rich plaque after the injection of N1177 was significantly higher and specific inside of the vessel wall than after injecting the conventional CT contrast agent.

“We were amazed a t these results. The introduction of N1177 allows us for the first time to look directly at the coronary arteries and pinpoint these dangerous, heart attack causing plaque,” said Dr. Fayad.

“N1177 had successfully progressed through Phase 1 clinical trials for use as a cancer staging agent,” said Don Skerrett, chief executive officer of NanoScan Imaging, LLC, and provider of N1177. “The unique properties of N1177 make it a versatile agent with a range of applications including: intravenous administration for the assessment of atherosclerosis and identification of vulnerable plaque, inhalation delivery for improved lung cancer staging and subcutaneous delivery for assessing cancerous extension into lymph nodes.”

The Mount Sinai researchers also believe this development may have broader clinical implication.

“N1177-enhanced CT will be helpful for diagnosis and prognosis of disease states. In the future, this technology may allow for the targeting of macrophages to specifically dispense therapeutic agents to disease tissue.”

Source-Newsise
SRM
'"/>




Related medicine news :

1. Imaging Modality That Might Help Diagnose Depression
2. Being Obese Increases Ones Risk Of A wrong Diagnosis During Medical Imaging
3. Optical Imaging Added To Ultrasound To Improve Imaging Of Breast Cancer
4. Using Eyes As The Line Of Reference For Fetal Brain Imaging
5. Three In One Ultrasound Probe For 3-D Imaging Of Heart And Tissue Destruction Developed
6. New Computerized Imaging Systems Help In Better Dental Treatment Planning
7. Magnetic Resonance Imaging Can Now Be Used For Mind Reading
8. New Cardiac Angiography Technique For Improved Imaging Of Coronary Veins
9. Brain Is More Active While Hiding The Truth, Reveals fMRI Imaging
10. 3-D Imaging For Monitoring Reactor Systems, Power Plants
11. Brian Imaging Can Foretell Results Of Treating Depression
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/7/2016)... ... February 07, 2016 , ... Women's Excellence staff, in all four locations, ... National Wear Red Day is the first Friday each February and a day to ... 1 in 3 deaths among women each year – more than all cancers combined. ...
(Date:2/6/2016)... ... February 06, 2016 , ... US Sports Camps is proud to sponsor ... event brings together top non-profit leaders, ultimate organizations, and coaches from around the US. ... Bay Area Disc Program Director of Youth and Education, describes this year YUCC as ...
(Date:2/5/2016)... ... February 05, 2016 , ... Steven Tonkinson, 36, of Coconut Grove, ... year since it started in 2003. This year, he ran all 26.2 miles with ... and NBA team the Miami Heat. , This Sunday, while many are watching the ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... stage for new clinical and scientific initiatives have all marked the last 12 ... appointed President and CEO of the nation’s oldest cancer center, Candace S. Johnson, ...
(Date:2/5/2016)... York, New York (PRWEB) , ... February 05, 2016 , ... ... life? The answer may be at the tips of your toes. Foot massage, whether ... as well as pure comfort and relaxation. The American Board of Multiple Specialties ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... 2016  Patients in Alabama seeking ... therapy no longer have to travel out of state. ... Urology Centers of Alabama to provide a total ... qualifying patients. Alabama is ... of prostate cancer using many different modalities. They are the ...
(Date:2/5/2016)... 5, 2016 --> ... states that the global active pharmaceuticals ingredients (APIs) market ... to reach US$185.9 bn by 2020. It is expected ... to 2020. The title of the report is "Active ... Geography, and by Therapeutic Area) - Global Industry Analysis, ...
(Date:2/5/2016)... Site Profile: --> Site ... People, announced their latest primary healthcare case study where speech recognition ... and to save the practice money. Site Profile: ... Challenge: --> ,- Wirral CCG ,- VoicePower client since ... Wirral CCG ,- VoicePower client since 2013 Challenge: ...
Breaking Medicine Technology: