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CD86 Found On B Cells Boosts Immune Response

According to researchers from Ohio state university it was found that CD86 present on the B lymphocytes increase the antibody produced by the lymphocyte.//

CD86 is a protein and it used to stimulate other immune cells such as T cells to respond to a stimulus or antigen. The study by Ohio State University scientists is published in a recent issue of The Journal of Immunology. The research, conducted in mouse cells, provides important details about how B cells make antibodies in response to infections.

Antibodies are proteins that attach to viruses, bacteria and other infectious agents to disable them. The findings could lead to new ways of boosting the immune response against bacteria that cause pneumonia, a leading killer of people with weakened immunity such as cancer and HIV/AIDS, and of controlling autoimmune diseases.

‘Our findings describe a previously unknown signaling pathway in B cells that helps regulate antibody production,’ says principal investigator Virginia M. Sanders, professor in department of molecular virology, immunology and medical genetics and an OSU Comprehensive Cancer Center researcher. ‘The findings show that CD86 actually sends signals into the B cell itself, causing it to make a greater amount of antibody. If this is verified in human cells, they could be clinically important.’ B cells begin making antibodies after they detect bits of bacteria, viruses or cancer cells in the body. But first the cells must be activated by contact with T cells in lymph nodes. During that interaction, CD86 proteins on the B cells fit like a key into a protein on the T cells called CD28.

If these and other proteins on the two cells also fit together properly, the T cell releases a substance that causes the B cell to proliferate and churn out antibodies against the antigen. But there was no indication that the interaction between the CD86 protein and a T cell had any influence on the B cell itself. Earlier work by San
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