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CCR5 Mutation Confers Immunity Against HIV But Not Against West Nile Virus Illness

5 percent of 247 WNV-positive samples from Arizona were from patients who had two copies of the CCR5 mutation. But only 0.7% showed the presence of 2 copies in case of the control group (145 WNV-negative blood samples).

In case of the WNV-positive samples from Colorado 4.1% of 148 samples came from individuals who had gene mutation on both the copies. Among the Coloradans who were WNV-positive and who self-reported their race as white, the percentage of homozygous individuals was 8.3.

In conclusion the researches said that CCR5 gene is very closely associated with the development of WNV infection. It would be of great significance to those who were been treated with CCR5 blockers to know that they are prone to WNV infection and should strictly limit mosquito exposure.


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