Navigation Links
C -reactive Protein is the Marker for Cardiovascular Disease

According to a new study of children ages 5 to 7,C-reactive protein, a marker of inflammation that is often used to detect cardiovascular disease, may also indicate cognitive impairment in children with obstructive sleep apnea.

Children with OSA have increased levels of hsCRP [high-sensitivty C-reactive protein] and also exhibit decreased cognitive performances, said lead researcher David Gozal, M.D., of the University of Louisville in Kentucky. Furthermore, hsCRP levels are significantly increased among patients with OSA and cognitive dysfunction.

These findings were published in the second issue of the July American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

To identify children for the study, parents in the Jefferson County (KY) Public School system were invited to complete a questionnaire about their childrens sleeping habits. Responses indicating almost no likelihood of OSA and those indicating a high likelihood of OSA were randomly selected, and the children were invited to a sleep research center.

Obese children were excluded from the study, because the condition is now viewed as a low-grade systemic inflammatory disorder, and is associated with increased risk for cognitive deficits.

At the sleep center, the children underwent overnight polysomnographic assessment and then, in the morning, completed tests to determine their reasoning and conceptual abilities.

The results of the individual tests were aggregated into a General Conceptual Ability (GCA) score, with a mean of 100 and a standard deviation of 15 Of a total of 278 children who completed all phases of the evaluation, 73 served as controls. They had no evidence of OSA and their cognitive scores were all normal.

Among the 102 children with OSA, 57 had GCA scores less than 85 percent. The mean level of hsCRP in children with OSA and abnormal scores was approximatel y 250 percent higher than the control group and approximately 200 percent higher than the level for children with OSA who did not exhibit cognitive impairment.

The authors suggest that an important question yet to be answered is whether OSA treatment would eliminate any cognitive deficits. They cite an earlier study they conducted which found that after an adenotonsillectomy, hsCRP levels in children with OSA were usually reduced.

According to the authors, however, the current findings reinforce the concept that systemic inflammation is a constitutive component and consequence of OSA and that the presence of increased systemic inflammation, as dictated by hsCRP levels and potentially the levels of other inflammatory markers, will increase the probability for decreased neurocognitive function.


'"/>




Related medicine news :

1. Artery Stiffness Linked To Increasing Levels Of C-reactive protein
2. C-reactive Protein (CRP) Levels Could Assess Future Lung Cancer Risk In Smokers
3. Lean Protein Could Be Key to Obesity Drugs
4. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
5. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
6. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
7. Protein in urine foresees heart disease
8. Levels Of Blood Proteins May Help Heart Disease Care
9. Protein signals need for heart surgery
10. Protein and fat improve memory
11. Clotting Protein plays a role in nerve repair
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... ... in post-acute health care, have expanded their existing home health joint venture through ... AccentCare has been operating a joint venture home health company with Asante, delivering ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the Los ... article to the newly revamped Cosmetic Town journal section, featuring articles ... procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi says ...
(Date:10/12/2017)... ... 12, 2017 , ... Leading pediatric oncology experts at Children’s National Health ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired ... Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and ... 2017 Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness will ... Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph ...
(Date:10/12/2017)... ... , ... In the United States, single-family home owners pay ... York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is $7,000 a ... rates, which contributes to the relatively lower cost of living in places like ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Divoti USA will engrave and process all non-coated stainless ... FDA requirements, which stipulates new criteria regarding medical device manufacture and ... ID jewelry such as Medical ID Bracelets, can rest assured that ... the new FDA requirements . ... Divoti offers this dark mark fiber laser engraving process with ...
(Date:10/11/2017)... FRISCO, Texas , Oct. 11, 2017 /PRNewswire/ ... healthcare services, has amplified its effort during National ... patients about hereditary cancer risks. ... Journal of Clinical Oncology calculated that more than ... to have inherited mutations in BRCA1 or BRCA2 and ...
(Date:10/7/2017)... IRVING, Texas , Oct. 6, 2017   ... industry with more than $100 billion in purchasing power, ... industry news and information. The Newsroom is ... chain and industry trends, infographics, expert bios, news releases, ... Besides having access to a wealth of resources at ...
Breaking Medicine Technology: