Navigation Links
'Bubble Boy' Gene Therapy Causes Cancer?

A new study published in the journal Nature has found that Gene therapy, which is used to treat children who possess no immune system could cause cancer//. US researcher, citing an animal study say that the treatment is used for children with X-SCID is more risky than previously thought.

However, experts from Great Ormond Street where nine children with the disease were successfully treated say that gene therapy in low doses does not cause any problems. They were of the opinion that the other studies used unnaturally high doses of the gene.

Gene therapy has had a mixed response with a French trail halted as three children developed leukemia. US researchers say this therapy, which inserts genes into the system damages healthy cells and causes cancer. X-SCID is a disease that develops due to the presence of a mutation in the IL2RG gene. This gene is responsible for the presentation of a protein that is vital to the development of several immune cells.

In the current study, a team of researchers from the Salk Institute for Biological Studies in La Jolla, California studied the effect of infecting the IL2RG gene into mice over a long period of time. The mice were injected with the same gene used to treat X-SCID and were followed for a period of 18 months. Researchers found that a third of the mice developed lymphoma within 10 months. 'We were surprised by the strength of the association,' said Dr Neils-Bjarne Woods, one of the scientists who carried out the research. 'These results suggest that curing X-SCID by replacing IL2RG in the manner it is currently being done puts patients at an increased risk of developing cancer.'

A French trial was halted after three children developed T-cell leukemia in 2002. Two cases developed since the IL2RG incorporated itself next to a cancer-causing gene, but the reason for the third case remains unknown. The Salk Institute researchers say that they could offer an explanation as to why this was happening.

'The bottom line here is that if you replace a gene that has multiple effects, you have to know more about its regulation and its ability to affect other genes, and that requires extensive preclinical work and a much more careful analysis,' said lead researcher Professor Inder Verma.

The gene therapy team at Great Ormond Street Hospital said that the study was not helpful, 'This is a very preliminary study published in an incomplete form. The researchers have taken artificially high doses of these genes and given them to animals. I'm not sure how it is relevant to human treatment,' said Professor Adrian Thrasher. 'We know already that, in lower doses, the gene therapy does not have that effect.'

Related medicine news :

1. Cancer Doctors Okays Controversial Prostate Therapy
2. Consensus on "Combination Therapy" for Breast Cancer
3. Gene Therapy shows promise in treating Hemophilia
4. "Make AIDS Therapy affordable" - Physicians demand
5. Hormone replacement Therapy a headache
6. Simple Therapy
7. Therapy for stopping the spread of cancer cells
8. Gene Therapy Destroys Pancreatic Cancer Cells
9. Letrozole Beats Tamoxifen in Breast Cancer Therapy
10. Garlic Supplements Impede HIV Therapy
11. Gene Therapy For Cystic Fibrosis
Post Your Comments:

(Date:11/30/2015)... ... 2015 , ... Thermi™, a world leader in thermistor-regulated energy ... temperature controlled radiofrequency platform has received CE marking and may now be sold ... as a clinical endpoint. The technology has been available in the United ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... the driverless vehicle experience this summer, ushering in a new era of publicly ... driverless and electric shuttle, will continue to offer guests an up-close look at ...
(Date:11/30/2015)... ... November 30, 2015 , ... On Saturday, October 24th, 2015, at the Mill ... fundraising event, a 5K walk known as “Making Strides Against Breast Cancer”. Patients and ... is also located in Battle Creek, joined in for this campaign that sought to ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... off its annual fundraising campaign to raise funds for its research, education, support, ... 10% of the organization’s annual funding. , The Mesothelioma Applied Research Foundation, which ...
(Date:11/30/2015)... ... November 30, 2015 , ... According to Los Angeles bariatric surgeon Michael ... not necessarily caused by real hunger, but instead by a hormone called ghrelin ... that, while many patients are aware that weight loss surgery can help patients lose ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 2015 (HK$,000)For the Six Months Ended 30 September 2015 2014RestatedChange%Turnover 545,575 ... 421,979 , 384,242 , 9.8 ... 34,719 , (18.3) Medical Insurance Administration Service Income ... 16.1 Medical Devices and Accessories Sales , 89,645 ... Medicines Sales , 2,822 , 2,917 ...
(Date:11/30/2015)... WOODCLIFF LAKE, N.J. and SAN ... Inc. and Arena Pharmaceuticals, Inc. (NASDAQ: ARNA ) ... (FDA) has accepted for filing the New Drug Application ... approved, the extended release formulation will offer patients a ... ® ) is currently approved as ...
(Date:11/30/2015)... CHICAGO , Nov. 30, 2015   Nuance ... The National Decision Support Company (NDSC) today ... support and collaboration capabilities that utilize the American College ... and healthcare provider organizations to comply with current ... --> --> By combining clinical ...
Breaking Medicine Technology: