Navigation Links
Breast reconstruction may be possible with fat stem cells

Breast cancer survivors will be able to do away with invasive breast reconstruction surgery, replaced by an approach involving stem cells //extracted from their own fat, suggest University of Pittsburgh researchers who are investigating the potential these cells may have for renewing new breast tissue.

In animal models, the researchers hope to prove that an injection of fat-derived stem cells that are seeded onto microscopic scaffold structures will enable the production of a durable, replacement soft tissue. The team, led by J. Peter Rubin, M.D., assistant professor of plastic and reconstructive surgery at the University of Pittsburgh School of Medicine, recently received a three-year grant from the National Cancer Institute to further explore this unique approach.

"The surgical options for breast reconstruction involve either the use of implants or a procedure whereby fat tissue taken from another part of the body is shaped into the form of a breast. Neither is ideal nor without risk. The use of adipose- or fat-derived stem cells may represent a better solution for soft tissue reconstruction in breast cancer patients," said Dr. Rubin, who also is co-director of the Aesthetic Surgery Center at the University of Pittsburgh Medical Center.

The use of stem cells to treat disease or regenerate tissue is believed to hold promise because of their potential to develop into different specialized cell types. Indeed, when exposed to specific conditions in the laboratory, fat-derived stem cells have been shown to differentiate into cells characteristic of those from tissues such as fat, bone, cartilage, nerve, muscle and blood vessels.

Dr. Rubin and his colleagues are focusing their efforts on an approach that involves combining the fat-derived stem cells with microscopic beads composed of a type of extracellular matrix (ECM) that has regenerative properties. Preliminary results indicate that the stem cells can easily attach thems elves to these beads and are able to differentiate into mature fat cells. When injected under the skin in a rat model, the cellular combination eventually formed what they describe as a "mound" of tissue.

The fat-derived stem cells being used in the study are obtained from breast cancer patients.

"We need to demonstrate that fat-derived stem cells taken from a breast cancer patient behave no differently than those from other women. Moreover, our studies will seek to understand what effect, if any, these stem cells may have on cancer cells. A major question is whether they will in some way promote the growth of cancer cells. We certainly hope this proves not to be the case," Dr. Rubin cautioned.

In 2001, researchers from the University of California Los Angeles and the University of Pittsburgh first reported that adult stem cells could be isolated from adipose tissue, more commonly known as fat. Since then, laboratory studies have suggested adipose-derived stem cells have potential for treating heart attack, stroke or bone injury, although there have been no clinical trials in the U.S. to date. Experts estimate that one pound of whole fat removed in a tummy tuck, for example, can yield up to 200 million stem cells, which in culture can be expanded by 10 times over the course of two weeks. If and when fat-derived stem cells are tried in patients for breast reconstruction, Dr. Rubin predicts surgeons will obtain the cells from the patients' own stores of abdominal fat.

According to the American Cancer Society, more than 214,000 new cases of invasive breast cancer will be diagnosed by the end of 2006. For women who require mastectomy, the loss of one or both breasts can cause significant discomfort and psychosocial distress. More than 80,000 breast reconstruction operations are performed each year, according to American Society of Plastic Surgeons statistics.

Source-Eurekalert
'"/>




Related medicine news :

1. Consensus on "Combination Therapy" for Breast Cancer
2. Breast cancer treatment to be determined by gene test
3. Breast Feeding prevents obesity later on in life
4. Breast milk is essential
5. Breast Cancer Surgery Causes Psychological problems
6. Breast cancer evidence
7. Letrozole Beats Tamoxifen in Breast Cancer Therapy
8. Breast screening among diabetic women
9. Breast feeding can alter hormones
10. Diet, Sunlight connected to Breast Cancer Risk
11. Additional Radiotheraphy for Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... , ... June 24, 2016 , ... People across the ... Genome magazine’s Code Talker Award, an essay contest in which patients and their families ... to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education ...
(Date:6/24/2016)... Frederick, Maryland (PRWEB) , ... June 24, 2016 ... ... Mid-Atlantic Angels is actively feeding the Frederick area economy by obtaining investment capital ... support over the past 2½ years that have already resulted in more than ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the upcoming 2016 Miss Arizona pageant as its official Medspa Sponsor. Dr. Josh ... Mesa, and Chandler, Arizona. , Dr. Olson says the decision to support ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology: