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Breast Cancer linked to Gene Risk

RCA2 phenocopies in women who tested negative for the mutations.

A phenocopy happens when a patient tests negative for the genetic fault but develops the condition to which it predisposes them. The findings of the research have been published in the Journal of Medical Genetics. According to the researchers the phenocopy is probably due to other alterations, or modifier genes, that mimic the changes produced by the specific genetic fault.

Evans said, "It is clear it is not the simple story of you either carry a high-risk gene or you don't. It is a spectrum of risks due to a whole host of genetic factors."

He added, "Even when you are in a high-risk family with BRCA1 and BRCA2, you still have to take into account these other genetic factors that may be in those families."

The International Agency for Research on Cancer (IARC) in Lyon, France has found that breast cancer is the most common cancer in women, with more than a million cases detected worldwide each year.
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