( s only by using a bacterial-like adjuva...)Breast Cancer Vaccine Stimulates Potent Immune Response to Cancer Cells,Health

s only by using a bacterial-like adjuvant administered with the right peptide," she said.

In addition, Dr. Nava-Parada said that other studies fail to accurately represent human cancers because they measure acute rejection of a tumor cell line that is produced in the laboratory and then injected into healthy animal models. Study models like the one described in this AACR presentation are thought to be more realistic because the study considers the entire natural history of the tumor in an animal that harbors the HER-2/neu gene.

"When the animal has a precancerous lesion, we vaccinate it and closely follow the appearance of the spontaneous tumor through its life. Conducting the research in this manner allows us to gain a clearer insight into a real-life cancer patient’s situation," she said.

Cancer vaccines are intended for patients with a strong genetic predisposition or personal history of cancer; patients who do not respond to traditional therapies; or, as a preventive measure for patients who have successfully completed traditional courses of treatment, such as surgery, radiation and/or chemotherapy.

Cancer Vaccine Mouse Models and Research Data Lost in Hurricane Katrina

Dr. Nava-Parada was a post-doctoral fellow at Mayo Clinic where she worked in the laboratory of Esteban Celis, M.D., Ph.D., a specialist in immunology and cancer research pursuing the development of a vaccine to treat and prevent breast cancer. In November 2004, Drs. Celis and Nava-Parada moved the research from Minnesota to Louisiana where they planned to continue the work with Tulane University and Louisiana State University. But Hurricane Katrina struck before they could resume the research. The data and colony of mice developed for the study were destroyed.

"When I lost the work, I decided to return to Mayo where Dr. Larry Pease, Ph.D., (chief of immunology) graciously gave me space in his lab to continue this work," Dr.
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