Navigation Links
Breakthrough in Type II Diabetes

"This is a big step forward in dissecting the pathways and mechanisms of diabetes. It is fascinating." Yes the researchers of Yale University have seen a break through in the identification of the missing protein in the adult onset Type II Diabetes mellitus.

They have discovered that mice lacking a gene that produces the enzyme called Akt2 or //Protein Kinase B are born without diabetes but develop symptoms of glucose intolerance after two months, roughly the same age that onset begins in humans.

Heading this mission of profound dimension Dr.Kim said that if studies in humans show that the lack of this protein has similar effects, the finding could lead to development of a therapeutic target for preventing Type-2 diabetes.

This study is is supported by Dr. Morris Birnbaum, a Howard Hughes Medical Institute investigator at the University of Pennsylvania Medical school, who devised the "Akt2 knock out mice". In the knockout mice, they discovered a partial defect in insulin-stimulated glucose uptake in the animals' muscle tissue. Further studies showed that the liver of the Akt2 knockout mice did not respond to insulin by lowering glucose production, and their tissues were consuming less glucose in response to insulin.

"This defect in insulin action in the liver and skeletal muscle altered glucose homeostasis throughout the body. Combined with the delayed onset, (it) suggests that Akt2 might have a role in the diabetes. The researchers are correct in stating that the finding presents an opportunity to test potential targets for drug development and hence the gene therapy.

But for the difficulty in using human subjects in such research it is that most adults are unaware they are becoming glucose intolerant until they are diagnosed with Type 2 diabetes at their later age.

Let us hope that future collaborations between the Yale and University of Pennsylvania researc h teams will result in further understanding the disease.

"This is the future of how we will come to understand the pathology of diabetes."


'"/>




Related medicine news :

1. Sperm washing helps couples – Breakthrough in focu
2. ZD1839 Proves Effective - A Breakthrough in fighting Lung Cancer
3. Breakthrough in eye treatment
4. Genetic Breakthrough in Common Eye Problem
5. Breakthrough in cancer therapy
6. Breakthrough In Stem Cell Work
7. A Likely Breakthrough For Prostate Cancer Patients
8. New DNA Breakthrough Can Change Future Of Medicine
9. Breakthrough In New Vaccine For Malaria
10. Medical Breakthrough - Kidney Transplant Recipient Survives Without Drugs
11. Breakthrough In Tasmanian Devil Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/21/2017)... ... July 21, 2017 , ... ... students improve their chances of acceptance to a residency in a United States ... earned degrees outside the U.S. , According to data released by the ECFMG®, ...
(Date:7/21/2017)... ... July 21, 2017 , ... West Dermatology is pleased ... Vu, PA-C. Beginning July 17, 2017, Ms. Vu will join West Dermatology’s large network ... experience in dermatology, skin cancer , and more. She graduated from the University ...
(Date:7/21/2017)... ... July 21, 2017 , ... How physicians and ... the rise, say researchers presenting their work at the American Orthopaedic Society ... combination of evaluating the patterns of change in concussion symptom presentation, diagnostic tools ...
(Date:7/20/2017)... ... July 20, 2017 , ... Acute myeloid leukemia (AML) is ... rapidly without treatment. Newly diagnosed patients face intense chemotherapy regimens and a stem ... With such a challenging diagnosis that requires immediate action, patients and caregivers ...
(Date:7/20/2017)... ... ... For individuals with extended hospital stays or who are residents of nursing ... specially designed to accommodate patients with a wide range of ailments or special needs, ... has invented the patent-pending PORTABLE ARM REST, a specially designed armrest that features many ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... and Company (NYSE: LLY ) has entered into ... litigation in the U.S. District Court for the Eastern District ... (tadalafil) unit dose patent. This patent was previously set ... agreement, Cialis exclusivity is now expected to end at the ... patent for Cialis is valid and infringed by companies seeking ...
(Date:7/11/2017)... 11, 2017  The global market for liquid biopsy ... $394.1 million in 2016.  Although in early stages, the ... in particular as a result of the gradual shift ... recent introduction of a significant number of new liquid ... of tumor biomarkers to guide treatment decisions. ...
(Date:7/11/2017)... July 11, 2017 Oramed Pharmaceuticals Inc. (NASDAQ: ... pharmaceutical company focused on the development of oral drug ... Drug Administration (FDA) has agreed to schedule an End-of-Phase ... IIb trial of its oral insulin capsule ORMD-0801 in ... trial met primary and secondary endpoints by indicating a ...
Breaking Medicine Technology: