Navigation Links
Breakthrough In The Identity Of Compounds That Encourage Stem Cell Growth

Scientists at Harvard University have identified key compounds that stimulate stem cell growth in the brain. //

The researchers whose findings, is set to appear in the September 2006 issue of The FASEB Journal hope that this discovery might one day lead to restored function for people who are affected by diseases like the Parkinson's, strokes, multiple sclerosis, and a wide range of neurological disorders. The researchers have explained that this could provide important clues as to which compounds may be responsible for causing key brain cells, neurons, to regenerate that could eventually restore the functions of the brain.

The research study focused on two compounds--LTB4 and LXA4. Both play a role in inflammation and are regulators of proliferation of several cell types. When stem cells isolated from the brains of mouse embryos were exposed to LTB4 they proliferated and differentiated, giving rise to additional stem cells and to differentiated neurons with limited or absent capacity to divide. When exposed to LXA4, these cells experienced decreased growth and apoptosis.

"This study opens doors to new therapeutic approaches for a wide range neurological disorders and injuries that were once considered incurable," said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal.

The study also provided so insight into the cellular and molecular mechanisms involved when LTB4 stimulates neuronal stem cells. According to the study, cells generated as the result of LTB4 exposure had high levels of LTB4 receptors, whereas the level of LTB4 receptors was considerably lower in similar cells not generated by LTB4 stimulation. The investigators were further able to show that LTB4 up-regulated several molecules involved in cell cycling and growth, such as cyclins and epidermal growth factor receptor, and decreased those such as caspase 8 which play a role in apoptosis. LXA4 had the opposite effects.

Source-Eurekalert
VIK
'"/>




Page: 1

Related medicine news :

1. Sperm washing helps couples – Breakthrough in focu
2. ZD1839 Proves Effective - A Breakthrough in fighting Lung Cancer
3. Breakthrough in eye treatment
4. Genetic Breakthrough in Common Eye Problem
5. Breakthrough in cancer therapy
6. Breakthrough in Type II Diabetes
7. Breakthrough In Stem Cell Work
8. A Likely Breakthrough For Prostate Cancer Patients
9. New DNA Breakthrough Can Change Future Of Medicine
10. Breakthrough In New Vaccine For Malaria
11. Medical Breakthrough - Kidney Transplant Recipient Survives Without Drugs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... The OSHA ... Training Institute Education Center headquartered in Northern California, has issued an important reminder ... at their worksites. Employers with workers exposed to high temperatures should establish ...
(Date:6/27/2016)... ... , ... "FCPX editors can now reveal their media with growing colorful split ... Austin - CEO of Pixel Film Studios. , ProSlice Color brings the split ... now reveal the media of their split screens with growing colorful panels. , ProSlice ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... announced today its affiliation with Tennessee Counseling Association. This new relationship ... of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA ...
(Date:6/27/2016)... (PRWEB) , ... June 27, ... ... in the patient payment industry today announced its strategic partnership with Connance, ... system workflows. , The two companies’ proven, proprietary technology combine to provide ...
(Date:6/27/2016)... ... 27, 2016 , ... A revolution is underway. Brooklyn-based ... experience for the millions of people who require these medical transport services annually. ... through the use of technology. Now, SmartEMS has put forth an industry-changing app ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... VIEW, Calif. , June 23, 2016 ... a.m. CST on Thursday, July 7, 2016 , , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  , ... Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa ... The global pharmaceutical industry is witnessing an ...
Breaking Medicine Technology: