Navigation Links
Breakthrough In Parkinson's research

The accumulation of clumps of the protein, alpha-synuclein, in the brain, in is considered to be the hallmark of Parkinson's disease// , according to Aaron Gitler, a postdoctoral scientist , at the Whitehead Institute in Cambridge, Massachusetts. He, along with fellow postdoctoral researcher, Anil Cashikar, are investigating the ways of preventing formation of these clumps, and also to understand if this might prevent the death of neurons, whose deterioration results in the symptoms of Parkinson’s disease.

They began their work with the simple yeast cells, employing an array engineered by the Harvard Institute of Proteonomics, and infected those cells with alpha-synuclein. They reasoned that if they identified genes that were expressed in a rescued cell, that would alert them about how alpha-synuclein harmed a cell.
.
Most of the genes they identified were involved in the production of cellular proteins and its folding into the appropriate shape. Working with researchers at the University of Missouri, Kansas City, they demonstrated that a mutated form of alpha-synuclein destroyed a key protein in this process, resulting in cell death.

The next step was to find a gene that could produce this key transport protein, in order to save the cells.

"We were surprised that when we tested this gene in higher animals -- fruit flies, worms, rat cells -- remarkably we could reverse Parkinson's symptoms in higher animals," Gitler said. "There are obvious implications for drug targets and the basic mechanism of how the disease occurs."

The researchers tried various methods of increasing production of the transport protein and in each case; the nerve cells were restored to health.

Their research findings appear in the June 23 issue of the journal Science.

Gitler added. "We hope that in the long run we can get a very good understanding of this and other cellular defects," he said. "Knowing these details will allow us and others to design therapies for Parkinson's disease and other disease."

Medical director of the National Parkinson Foundation and co-director of the University of Florida's Movement Disorders Center, Dr. Michael S. Okun, said” the new study provides potentially important information for researchers interested in the neurodegenerative process that leads to Parkinson's disease. The information from this study will be potentially useful to investigators around the world interested in why brain cells die in Parkinson's disease, and the results will hopefully be applied to more complex research model systems," Okun said.

Parkinson's disease is a brain disorder that occurs when certain nerve cell impairment or death results . Symptoms include tremors, stiffness, slowness of movement, muffled speech and depression, and difficulty in co ordination.

1.5 million Americans have the disease, with 60,000 new cases being diagnosed annually. According to the National Parkinson Foundation , the condition usually begins to affect after 65 years.


'"/>




Related medicine news :

1. Sperm washing helps couples – Breakthrough in focu
2. ZD1839 Proves Effective - A Breakthrough in fighting Lung Cancer
3. Breakthrough in eye treatment
4. Genetic Breakthrough in Common Eye Problem
5. Breakthrough in cancer therapy
6. Breakthrough in Type II Diabetes
7. Breakthrough In Stem Cell Work
8. A Likely Breakthrough For Prostate Cancer Patients
9. New DNA Breakthrough Can Change Future Of Medicine
10. Breakthrough In New Vaccine For Malaria
11. Medical Breakthrough - Kidney Transplant Recipient Survives Without Drugs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... January 20, 2017 , ... Bionic Sports Nutrition LLC, ... of life, announced it had a successful January ECRM Trade Show in Hilton Head, ... United States, which allows it to provide its products to all clients at reasonable ...
(Date:1/20/2017)... ... January 20, 2017 , ... "TransFlare 4K Mystique comes with 44 colorful mysterious ... X," said Christina Austin - CEO of Pixel Film Studios. , TransFlare 4K ... 4K Mystique lens flare and light leak transitions have a very high-dynamic range for ...
(Date:1/20/2017)... ... 20, 2017 , ... “I Forgive You”: a fine examination of how God handles sin, ... creation of published author, Stephen Miller, who, for over ten long years has been waiting ... Born in Trinidad and Tobago, he has been serving the Lord for over twenty years, ...
(Date:1/20/2017)... ... 2017 , ... “The Land of More and More”: a brilliant story ... and shares the simple and achievable answer. “The Land of More and More” is ... Missionary Church in Angola, Indiana where he works with the children’s ministry department. ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... expansion and facility enhancement of their 503A compounding pharmacy located in Ocala, Florida. ... demand of physicians and patients throughout the United States for high-quality human ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... , Jan. 19, 2017 The Global Therapy ... and access to partnering deals and agreements entered into ... in partnering deals - Top deals by value - ... development, technology type The report provides understanding and ... by the world,s leading healthcare companies. The report ...
(Date:1/19/2017)... Report Details ... Alzheimer,s Disease Therapeutics and ... our new study reveals trends, R&D progress, and predicted ... the Alzheimer,s disease therapeutics and diagnostics market. Our new ... - How is the Alzheimer,s disease therapeutics and diagnostics ...
(Date:1/19/2017)... 2017  Stealth BioTherapeutics Inc. ( Stealth ), a ... today announced new additions to its senior leadership team: ... Officer, and Daniel Geffken as interim Chief ... Carr , Pharm.D. has been promoted to Chief Clinical ... welcome Doug and Daniel to our management team, as ...
Breaking Medicine Technology: