( boration with the Butantan Institute on...)Brazilian Boost for Bird Flu Vaccines,Health

boration with the Butantan Institute on the development of a potential H5N1 influenza vaccine.

According to Raw, use of MPLA could allow Brazil and other developing countries to produce their own vaccines, instead of relying on imports from developed countries.

There are currently no vaccines for H5N1 avian influenza available. The WHO says that vaccines are under development in several countries, but because a vaccine needs to closely match the pandemic virus in circulation, large-scale production would not start until the virus has been properly identified.

Thus, no vaccine is expected to be widely available until several months after the start of a pandemic.

According to the WHO, manufacturers from ten countries are developing prototype vaccines in cell cultures or in eggs inoculated with the virus. More then 40 clinical trials have been completed or are ongoing to test whether the experimental vaccines will work, and to determine the best formulation to boost production capacity.

But the WHO warns that current global production capacity falls far short of the demand expected during a pandemic. It estimates that about 12 billion doses are required to vaccinate the entire world's population with the two-doses needed to protect each person.

Current capacity is estimated at less than 400 million doses per year and this is not expected to exceed 2.3 billion doses per year by 2008–2009.

Countries such as China, India, Thailand and Vietnam are taking steps to ensure that they have their own vaccines available. Last month, Indonesia stirred controversy by signing an exclusive agreement to supply virus samples to a US pharmaceutical company in exchange for technology to manufacture a vaccine.

The WHO is helping several developing countries, including Cambodia, Egypt, Laos, Nigeria and Vietnam, to establish their own flu vaccine production facilities.

Source-Bio-Bio
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