Navigation Links
Brazilian Boost for Bird Flu Vaccines

Brazilian scientists have developed a modifying agent which could make vaccines for the H5N1 bird flu virus cheaper, more effective, and easier to produce//.

The development could help developing countries at the forefront of any bird flu pandemic struggling to access and afford the vaccines and drugs produced and stockpiled by developed countries.

Researchers from the Butantan Institute, based in S?o Paulo, Brazil, claim that an adjuvant called Monophosphoryl Lipid A (MPLA) was effective in boosting the immune response to strains of Vietnamese and Indonesian avian flu virus in mice.

An adjuvant is a chemical substance that boosts a vaccine's effectiveness by increasing its ability to stimulate the immune system.

According to Isaías Raw, director of the institute, MPLA reduced the amount of antigen — virus protein — needed to cause an immune response to one quarter of that previously required, reducing the cost of vaccine production.

Raw says were a pandemic to occur now, the adjuvant would enable 80–100 million doses of seasonal flu vaccine to be produced by the end of April.

Clinical trials in humans are planned, with results expected at the end 2008.

John Oxford, scientific director of Retroscreen Virology Ltd and professor of virology at UK-based Queen Mary's School of Medicine and Dentistry, said the adjuvant "looks to be a most interesting and practical step forward that will be needed in the face of a pandemic."

He also stressed the importance of increased hygiene and isolation procedures as well as the building a stockpile of antiviral drugs.

Marie-Paule Kieny, director of the World Health Organization (WHO) Initiative for Vaccine Research, cautioned that results were still only available for mice and that it was too early to assess the vaccine's effectiveness in humans.

But she welcomed the development and said the WHO had initiated colla boration with the Butantan Institute on the development of a potential H5N1 influenza vaccine.

According to Raw, use of MPLA could allow Brazil and other developing countries to produce their own vaccines, instead of relying on imports from developed countries.

There are currently no vaccines for H5N1 avian influenza available. The WHO says that vaccines are under development in several countries, but because a vaccine needs to closely match the pandemic virus in circulation, large-scale production would not start until the virus has been properly identified.

Thus, no vaccine is expected to be widely available until several months after the start of a pandemic.

According to the WHO, manufacturers from ten countries are developing prototype vaccines in cell cultures or in eggs inoculated with the virus. More then 40 clinical trials have been completed or are ongoing to test whether the experimental vaccines will work, and to determine the best formulation to boost production capacity.

But the WHO warns that current global production capacity falls far short of the demand expected during a pandemic. It estimates that about 12 billion doses are required to vaccinate the entire world's population with the two-doses needed to protect each person.

Current capacity is estimated at less than 400 million doses per year and this is not expected to exceed 2.3 billion doses per year by 2008–2009.

Countries such as China, India, Thailand and Vietnam are taking steps to ensure that they have their own vaccines available. Last month, Indonesia stirred controversy by signing an exclusive agreement to supply virus samples to a US pharmaceutical company in exchange for technology to manufacture a vaccine.

The WHO is helping several developing countries, including Cambodia, Egypt, Laos, Nigeria and Vietnam, to establish their own flu vaccine production facilities.

Source-Bio-Bio Technology'"/>




Related medicine news :

1. Brazilian Women to Be Vaccinated To Prevent Uterine Cancer
2. Hepatitis G May Boost HIV Survival
3. Drug Combinations May Boost Stroke Risk
4. Reduced Fatigue Boosts Mental Health
5. Therapy Boosts Chemotherapy Effects
6. Need for Hepatitis Booster Questioned
7. Vasopressin Found To Boost Survival In Sudden Cardiac arrest
8. Exercising To Music Found To Boost Brain Power
9. Consuming Fish During Pregnancy Boosts Child’s I
10. Vitamin Supplements During Pregnancy to Boost Fetal Development
11. Immune Boost With LHRH To Help Cancer And Transplant Patients
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2016)... ... February 12, 2016 , ... The ThedaCare ... San Francisco General Hospital on April 5-7. The series is a multi-day, multi-workshop ... habits. The workshops cover a broad range of topics, including coaching skills, the ...
(Date:2/12/2016)... ... 2016 , ... Fisher House Foundation Chairman and CEO Kenneth Fisher joined Governor ... Alliance president Scott Bensing, and Peggy Kearns Director, VA Southern Nevada Healthcare System yesterday ... This will be the first Fisher House in Nevada, and will provide free lodging ...
(Date:2/12/2016)... ... ... Vail knee specialist Robert LaPrade, MD, PhD was named one of ... of physicians establishing, leading and partnering with ambulatory surgery centers across the United States. ... also known as an ASC, is a modern health care facility focused on providing ...
(Date:2/12/2016)... ... ... Donor Network West, the organ procurement organization that heals lives through organ ... Regional Medical Center. Under the collaboration, the first of its kind, specific organ donors ... certain time frame for donor families for the recovery of organs. , Organ ...
(Date:2/12/2016)... ... 12, 2016 , ... J Thomas & Associates Insurance Agency, ... to act as Agents of Change in the community, announces a new partnership ... to fulfill immediate needs and help them move into permanent housing. Donations to ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016 The primary goal ... future adoption patterns on the usage of liquid biopsy. ... following: - Timeframe of liquid biopsy adoption ... cfDNA and Evs—by organization type - Sample inflow to ... blood, saliva, stool, serum, and so on. - Correlation ...
(Date:2/11/2016)... 2016 PRO-DEX, INC. (NasdaqCM: PDEX) today announced financial ... 2015. The Company also filed its Quarterly Report on Form ... the Securities and Exchange Commission today. --> ... --> --> Net sales for ... or 95%, to $5.4 million from $2.8 million for the ...
(Date:2/11/2016)... , Feb. 11, 2016  Kindred Biosciences, Inc. ... saving and improving the lives of pets, today announced ... of the New Animal Drug Application (NADA) for Zimeta™ ... field study (KB0120) of Zimeta for the control of ... Company. --> --> ...
Breaking Medicine Technology: