Navigation Links
Brazil Spider Offers Hope for Those Suffering from Erectile Dysfunction

In Brazil, emergency room staff can immediately spot the victims of a bite from the Brazilian wandering spider (Phoneutria nigriventer). Patients not only experience// overall pain and an increase in blood pressure, they also sport an uncomfortable erection. And therein perhaps lies the key to the quest for more Viagras. Scientists say they have figured out the chemical that seems to be responsible for the penis boost.

“The erection is a side effect that everybody who gets stung by this spider will experience along with the pain and discomfort,” said study team member Romulo Leite of the Medical College of Georgia. “We’re hoping eventually this will end up in the development of real drugs for the treatment of erectile dysfunction.”

The research was presented at a poster session of the American Physiological Society (APS) annual meeting at Washington.

A recent, nationally representative study by researchers at Johns Hopkins University found that about 18 million men in the United States suffer from erectile dysfunction. Research has shown that about one in three men with mild to moderate forms of erectile dysfunction don’t respond to Viagra, with some of these men having success with either Levitra or Cialis. And men with severe erectile dysfunction have less success with the drugs.

Kenia Pedrosa Nunes of the Medical College Georgia, Leite and colleagues separated the different components of the spider venom and ran tests on rats to eek out the erectile enhancer. Dubbed Tx2-6, the compound turned out to be a relatively short string of amino acids called a peptide.

Then, they injected the venom-chemical into rats stimulated to begin an erection. A tiny needle-like device inserted into each rat’s penis measured the pressure change, which corresponds with the increase in blood flow to the blood vessels inside the penis. Compared with control rats, those injected with the peptide showed a significant increase in penis pressure.

The scientists also found an increase in nitric oxide within the two main cylindrical cavities that run the length of the penis and are called corpora cavernosa. The significance of the nitric oxide is clear when the science behind an erection is considered: The brain senses sexual arousal in the body and certain neurons produce nitric oxide, a message telling the body to get started in making an erection. A cascade of biochemical steps occurs, one of which includes the production of an enzyme dubbed cGMP. This enzyme causes the smooth muscles of the penis’ two cylinders to relax so that blood can rush in and fill up the now expandable tubes. (A human penis can hold about 10 times more blood when erect compared with its non-erect state.)

“All of this leads to vaso-dilation of vessels that go through the penis and also relaxation of those [cylindrical tube muscles],” Leite told LiveScience. “They need to relax so the blood will come inside and that’s how you get an erection, because the blood gets trapped into the penis.”

But erections don’t last forever. The erectile party crasher, a substance called PDE-5 breaks down the cGMP and in turn transforms the erect penis into its normal limp state.

The most popular erectile-dysfunction drugs—Viagra, Cialis and Levtra—work by blocking this party crasher.

The spider chemical works in a different manner, affecting an earlier step in the erection process. Somehow, the toxin ups the amount of nitric oxide, which sort of sets into motion an erection. The scientists suggest that a combination of a synthetic version of the spider venom with a drug like Viagra would result in a magnified effect.

“So the combination of the two drugs could be even more efficient in patients that don’t respond well to Viagra,” Leite said.

SourceMedindia
GPL/V
'"/>




Related medicine news :

1. Brazil & Kenya Seek Support For A New Resolution At WHO’s Annual Mee
2. Brazilian Women to Be Vaccinated To Prevent Uterine Cancer
3. Malaria and TB Kills Indian Kids in Brazil
4. 13,000 Cases of Dengue Found in Brazil in January
5. Down Syndrome Dolls in Brazil After Child Actors Success
6. Brazil’s Claim to Fame - Fat Women and Drunk Men, Survey Find
7. Brazilian Boost for Bird Flu Vaccines
8. Brazil Will Purchase Merck’s Antiretroviral If Price Not Lowere
9. Brazil Government In Contention With Merck Over Anti-AIDS Drug
10. Pancreatitis: Minimially Invasive Procedure Offers Long-Term Pain Relief
11. Drug Offers Hope for Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health ... technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing ... form that can be easily incorporated into liquid products, while reducing costs to end ...
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... DevOps and Agile Software Development, has been awarded a contract by the Center ... Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of ... announced today its plans to open a flagship location in Covington, LA at 401 ... Rooms To Go store next to Office Depot in the Holiday Square shopping center. ...
(Date:10/12/2017)... ... 12, 2017 , ... Information about the technology: , Otomagnetics ... enable prevention of a major side effect of chemotherapy in children. Cisplatin and ... For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Texas , Oct. 11, 2017  True ... services, has amplified its effort during National Breast ... about hereditary cancer risks. ... of Clinical Oncology calculated that more than 10 ... have inherited mutations in BRCA1 or BRCA2 and have ...
(Date:10/7/2017)... , Oct. 6, 2017   Provista, a ... than $100 billion in purchasing power, today announced a ... information. The Newsroom is the online home ... trends, infographics, expert bios, news releases, slideshows and events. ... to a wealth of resources at their fingertips, viewers ...
(Date:10/4/2017)... 4, 2017 OBP Medical , ... medical devices, today announced regulatory approval from ... (or Agência Nacional de Vigilância Sanitária (ANVISA)) to ... surgical retractor with integrated LED light source and ... and exposure of a tissue pocket or cavity ...
Breaking Medicine Technology: