Navigation Links
Brain’s "Default Mode" Awry in Schizophreni

The 'default mode,' or baseline condition when the brain is idling, is not properly coordinated in patients with schizophrenia and this aberrant activity// may be caused by poor connectivity between brain networks, a Yale School of Medicine researcher reports.

Co-author Godfrey Pearlson, M.D., professor of psychiatry, said he and his colleagues found that regions of the brain known previously to be individually abnormal in patients with schizophrenia, also function abnormally in concert in the default mode network.

'In addition, the extent of the default mode abnormalities correlated with the severity of auditory hallucinations, delusional thoughts, and attention deficits that are hallmarks of schizophrenia,' Pearlson said.

Although the exact role of the default network is unknown, it is thought to involve response to stimuli as well as self-referential and reflective activity that includes memory retrieval, inner speech, mental images, emotions, and planning of future events.

Schizophrenia is a psychotic disorder that alters patients’ perception, thought processes, and behavior as evidenced by hallucinations, delusions, disorganized speech or behavior, social withdrawal, and varied cognitive deficits. Episodic memory and attention are significantly impaired in schizophrenia.

A central feature of schizophrenia is disturbed integration of activity across multiple brain regions, or dysfunctional connectivity between frontal temporal brain regions. Symptoms of schizophrenia have been attributed to a failure of functional integration or aberrant connectivity among regions or systems of the brain.

The study included 21 patients with schizophrenia and 22 healthy subjects. The group performed a straightforward task while undergoing functional magnetic resonance imaging in which they were asked to detect an infrequent target sound within a series of standard and novel sounds. In the healthy subjects, th e default mode network resonated slowly and regularly as observed by blood flow. In the patients with schizophrenia, the activity in the brain increased and was significantly more irregular, although they performed equally well on the task.

Source-YALE University
'"/>




Related medicine news :

1. Brain’s response distinct upon exposure to erotic image
2. Brain’s natural Antioxidant Defense Syste
3. Arthritis Pain Processed in Brain’s fear Zone, First PET Scans Revea
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/22/2017)... San Antonio, TX (PRWEB) , ... May 22, 2017 , ... ... It starts with a body squatted, stretched, jumped, toned and shaped through fitness programs. ... And it is, of course, finished off with an irresistible, radiant smile. CDA ...
(Date:5/21/2017)... Texas (PRWEB) , ... May 19, 2017 , ... ... is pleased to announce the appointment of James (Jim) Vertino as Chief Information ... is a proven, transformational leader who drives innovation and business performance. He defines ...
(Date:5/21/2017)... ... May 21, 2017 , ... For the past ... group of scholars, policymakers, and activists wanting to address equity issues in breastfeeding, ... the third book from a recent series of from this conference. , ...
(Date:5/21/2017)... ... May 21, 2017 , ... ... been longer than six months since you've seen a dentist, it's time for ... year and getting x-rays once per year. , Dental checkups are a relatively ...
(Date:5/19/2017)... , ... May 19, 2017 , ... When Kyle Busch ... his name will already appear on two major research studies that could impact the ... with Dr. Matt Daggett, KCU alumnus and an orthopedic surgeon, alongside an international team ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... 2017 Clarius Mobile Health, a digital ... scanners this week at the American Congress of ... San Diego, CA from ... the perfect tool for clinicians to easily confirm ... evaluate pregnancy-related complications like ectopic pregnancy and placenta ...
(Date:5/4/2017)... May 4, 2017  DarioHealth Corp. (NASDAQ: DRIO), a ... big data solutions, today announced that it is teaming ... STI Technologies Limited to lower diabetes healthcare costs in ... innoviCares card, which is available throughout all provinces and ... will be eligible for additional savings when shopping for ...
(Date:5/4/2017)... BOTHELL, Wash. , May 4, 2017   ... a leading developer, manufacturer and marketer of proprietary clinical ... media ("BioLife" or the "Company"), today announced that ... released after market close on Thursday, May 11, 2017, ... and live webcast at 1:30 p.m. PT that afternoon. ...
Breaking Medicine Technology: