Navigation Links
Brain’s "Default Mode" Awry in Schizophreni

The 'default mode,' or baseline condition when the brain is idling, is not properly coordinated in patients with schizophrenia and this aberrant activity// may be caused by poor connectivity between brain networks, a Yale School of Medicine researcher reports.

Co-author Godfrey Pearlson, M.D., professor of psychiatry, said he and his colleagues found that regions of the brain known previously to be individually abnormal in patients with schizophrenia, also function abnormally in concert in the default mode network.

'In addition, the extent of the default mode abnormalities correlated with the severity of auditory hallucinations, delusional thoughts, and attention deficits that are hallmarks of schizophrenia,' Pearlson said.

Although the exact role of the default network is unknown, it is thought to involve response to stimuli as well as self-referential and reflective activity that includes memory retrieval, inner speech, mental images, emotions, and planning of future events.

Schizophrenia is a psychotic disorder that alters patients’ perception, thought processes, and behavior as evidenced by hallucinations, delusions, disorganized speech or behavior, social withdrawal, and varied cognitive deficits. Episodic memory and attention are significantly impaired in schizophrenia.

A central feature of schizophrenia is disturbed integration of activity across multiple brain regions, or dysfunctional connectivity between frontal temporal brain regions. Symptoms of schizophrenia have been attributed to a failure of functional integration or aberrant connectivity among regions or systems of the brain.

The study included 21 patients with schizophrenia and 22 healthy subjects. The group performed a straightforward task while undergoing functional magnetic resonance imaging in which they were asked to detect an infrequent target sound within a series of standard and novel sounds. In the healthy subjects, th e default mode network resonated slowly and regularly as observed by blood flow. In the patients with schizophrenia, the activity in the brain increased and was significantly more irregular, although they performed equally well on the task.

Source-YALE University
'"/>




Related medicine news :

1. Brain’s response distinct upon exposure to erotic image
2. Brain’s natural Antioxidant Defense Syste
3. Arthritis Pain Processed in Brain’s fear Zone, First PET Scans Revea
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A ... 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the ... history as home to some of the world’s leading providers of cereal and other ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
(Date:6/23/2016)... June 23, 2016 Bracket , a leading ... next generation clinical outcomes platform, Bracket eCOA (SM) 6.0, ... June 26 – 30, 2016 in Philadelphia ... Clinical Outcome Assessment product of its kind to fully integrate ... Bracket eCOA 6.0 is a flexible platform for electronic ...
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
Breaking Medicine Technology: