Navigation Links
Brain Tumor Patients Survival Depends on Predicting Treatment Responses Earlier

WASHINGTON, D.C. A first-of-its-kind study presented at the 54th Annual Meeting of SNM, the world's largest society for molecular imaging and nuclear medicine professionals , declares that use of metabolic or molecular imaging to measure brain tumor patients' response to treatment is a powerful predictor of survival.

"Our study opens the door to the possibility that brain tumor patients may live longer and respond better to drug treatments," said Wei Chen, assistant professor in the Department of Molecular and Medical Pharmacology at the David Geffen School of Medicine, University of California, Los Angeles. "Malignant brain tumors are very difficult to treat. Typically, patients live for three months without treatment and up to a year with treatment," she said.

Using positron emission tomography (PET) imagingwith the radiotracer FLT (fluorothymidine)UCLA researchers were able to determine within one or two weeks after starting the treatment whether patients were responding well to the drugs bevacizumab and irinotecan. This quick response determination "is unheard of" with the traditionally used magnetic resonance imaging, a procedure that looks at the anatomy rather than metabolic activities of tumor cells, she explained. With MRI, it is often difficult to tell tumor growth from changes caused by treatment (such as radiation). In addition, it could take months before it's known whether a patient is responding to treatment, said Chen.

A brain tumor is an abnormal mass of tissue that grows and multiplies uncontrollablytaking up space within the skull and interfering with the brain's vital functions. Malignant brain tumors are rapidly fatal, said Chen. This year, nearly 21,000 people in this country will be diagnosed with brain and other related nervous system tumors in this country and nearly 13,000 individuals will die from them. Neurooncologists are desperately in need of an imaging modality that could evaluate reliably and rapidly the response to a treatment, she added.

"We studied the predictive value of PET with FLT, a marker of cell proliferation, in patients with recurrent malignant brain tumors, said Chen. "We used molecular imaging to measure the changes of metabolism in tumor cells," and FLT-PET provided much higher response rates than MRI, she explained. Additionally, the research shows the FLT-PET imaging is predictive of patients' outcomesindicating that in those cases where patients responded to drug treatment, they lived three times as long as those who did not, she added.

"FLT-PETas an imaging biomarkeris strongly predictive of overall survival for these patients with brain cancer," she noted. "No matter one's age, number of times cancer recurred or number of prior drug treatmentsFLT-PET was the most powerful independent predictor of survival," she said.

The drug bevacizumab is an antiangiogenic agent, which inhibits the development of blood vessels that supply blood and oxygen that contribute to a tumor's growth, said Chen. "Until this study, there were no reliable predictors of therapeutic response for patients with primary brain tumors undergoing treatment with these types of drugs," said Chen. "Our research paves the way for developing drugs that could improve the lives of those with malignant brain tumors," said Chen, adding that research will continue factoring in metabolic response into drug treatment.

PET is a safe, highly specialized, noninvasive imaging technique that uses short-lived radioactive substances to produce three-dimensional images of those substances functioning within the body. A special type of camera works with computers to provide precise pictures of the areas of the body being imaged and molecular images of the body's biological functions.


'"/>




Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Brain death – How to cope with it
3. “Brain fingerprinting”- The new lie detectr
4. Nasal Spray Could Take Drugs Direct to Brain.
5. Virus Combats Brain Tumour
6. Nasal Spray Could Take Drugs Directly to Brain
7. Control of anger disorder connected to Brain Dysfunction
8. High Levels of Protein Linked to Brain Shrinkage
9. Brain damage affects artistic skill
10. Brain cells protected by new compounds
11. Brain changes observed in people with sleep apnoea
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... , ... April 24, 2017 , ... Ridgecrest Herbals makes ... sustainability, innovate new strategies to reduce waste, and support renewable energy. They believe this ... look to nature to find solutions for health issues, and maintain that destroying the ...
(Date:4/24/2017)... ... April 24, 2017 , ... Today, Bright Pink , a national non-profit organization focusing ... a new CEO. , Bright Pink is proud to announce Katie Thiede as their ... to a new role as Chairman of the Board and launched a national search ...
(Date:4/24/2017)... ... 2017 , ... The John P. McGovern Museum of Health and Medical Science ... their cognitive health, and share results with their physicians. Members and guests can sign ... website. , BrainCheck founder, Dr. David Eagleman, formerly at Baylor College of Medicine and ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... ... advisor within the telehealth industry, announces the company’s VideoMedicine mobile platform has launched ... providers. Available 24 hours a day, Quick Care provides patients with the option ...
(Date:4/24/2017)... ... April 24, 2017 , ... MAP Health ... anxiety levels in people with addiction who are served by MAP’s patient engagement ... wearable device that monitors heart and breath rates to identify anxiety levels and ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... provides evidence that an old drug may provide relief for ... that will be presented at the American Academy of ... , April 22 to 28, 2017. When ... drug levodopa has long been considered the gold standard, improving ... the effects of the medication can partially wear off more ...
(Date:4/18/2017)... , April 18, 2017 Cogentix Medical, ... on providing the Urology, Uro/Gyn and Gynecology markets with ... the first quarter ended March 31, 2017 after the ... The Company will host a conference call and ... on Tuesday, May 2, 2017 at 4:30 p.m. Eastern ...
(Date:4/18/2017)... and BLOOMINGTON, Minn. ... (NASDAQ: IMMY ) ("Imprimis"), an ophthalmology-focused ... Lens ("Precision Lens"), today announced the signing of ... agreement, Precision Lens will deploy a dedicated sales ... geographies in the U.S., primarily focused in 13 ...
Breaking Medicine Technology: