Navigation Links
Brain Tumor Patients Survival Depends on Predicting Treatment Responses Earlier

WASHINGTON, D.C. A first-of-its-kind study presented at the 54th Annual Meeting of SNM, the world's largest society for molecular imaging and nuclear medicine professionals , declares that use of metabolic or molecular imaging to measure brain tumor patients' response to treatment is a powerful predictor of survival.

"Our study opens the door to the possibility that brain tumor patients may live longer and respond better to drug treatments," said Wei Chen, assistant professor in the Department of Molecular and Medical Pharmacology at the David Geffen School of Medicine, University of California, Los Angeles. "Malignant brain tumors are very difficult to treat. Typically, patients live for three months without treatment and up to a year with treatment," she said.

Using positron emission tomography (PET) imagingwith the radiotracer FLT (fluorothymidine)UCLA researchers were able to determine within one or two weeks after starting the treatment whether patients were responding well to the drugs bevacizumab and irinotecan. This quick response determination "is unheard of" with the traditionally used magnetic resonance imaging, a procedure that looks at the anatomy rather than metabolic activities of tumor cells, she explained. With MRI, it is often difficult to tell tumor growth from changes caused by treatment (such as radiation). In addition, it could take months before it's known whether a patient is responding to treatment, said Chen.

A brain tumor is an abnormal mass of tissue that grows and multiplies uncontrollablytaking up space within the skull and interfering with the brain's vital functions. Malignant brain tumors are rapidly fatal, said Chen. This year, nearly 21,000 people in this country will be diagnosed with brain and other related nervous system tumors in this country and nearly 13,000 individuals will die from them. Neurooncologists are desperately in need of an imaging modality that could evaluate reliably and rapidly the response to a treatment, she added.

"We studied the predictive value of PET with FLT, a marker of cell proliferation, in patients with recurrent malignant brain tumors, said Chen. "We used molecular imaging to measure the changes of metabolism in tumor cells," and FLT-PET provided much higher response rates than MRI, she explained. Additionally, the research shows the FLT-PET imaging is predictive of patients' outcomesindicating that in those cases where patients responded to drug treatment, they lived three times as long as those who did not, she added.

"FLT-PETas an imaging biomarkeris strongly predictive of overall survival for these patients with brain cancer," she noted. "No matter one's age, number of times cancer recurred or number of prior drug treatmentsFLT-PET was the most powerful independent predictor of survival," she said.

The drug bevacizumab is an antiangiogenic agent, which inhibits the development of blood vessels that supply blood and oxygen that contribute to a tumor's growth, said Chen. "Until this study, there were no reliable predictors of therapeutic response for patients with primary brain tumors undergoing treatment with these types of drugs," said Chen. "Our research paves the way for developing drugs that could improve the lives of those with malignant brain tumors," said Chen, adding that research will continue factoring in metabolic response into drug treatment.

PET is a safe, highly specialized, noninvasive imaging technique that uses short-lived radioactive substances to produce three-dimensional images of those substances functioning within the body. A special type of camera works with computers to provide precise pictures of the areas of the body being imaged and molecular images of the body's biological functions.


'"/>




Related medicine news :

1. Use of Cellular Phones associated with Increased risk of Brain Tumors
2. Brain death – How to cope with it
3. “Brain fingerprinting”- The new lie detectr
4. Nasal Spray Could Take Drugs Direct to Brain.
5. Virus Combats Brain Tumour
6. Nasal Spray Could Take Drugs Directly to Brain
7. Control of anger disorder connected to Brain Dysfunction
8. High Levels of Protein Linked to Brain Shrinkage
9. Brain damage affects artistic skill
10. Brain cells protected by new compounds
11. Brain changes observed in people with sleep apnoea
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/25/2016)... ... ... Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and Mental ... exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took place ... BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive an ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- , , , WHEN: , ... , , , LOCATION: , , , Online, with free ... EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice President ... Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... is witnessing an exceptional era. Several new demand spaces, such as ...
(Date:6/23/2016)... , June 23, 2016 Revolutionary ... Oticon , industry leaders in advanced audiology ... of Oticon Opn ™, the world,s first internet ... possibilities for IoT devices.      (Photo: ... introduces a number of ,world firsts,: , ...
(Date:6/23/2016)... 2016 Research and Markets has ... Global Analysis (United States, China, Japan, Brazil, United Kingdom, ... their offering. Surgical ... business planners, provides surgical procedure volume data in a ... an in-depth analysis of growth drivers and inhibitors, including ...
Breaking Medicine Technology: