( ecular kingpin in the realm of inflamma...)Brain Inflammation A Friend for Alzheimer's Patients,Health

ecular kingpin in the realm of inflammation.

IL-1 beta, a signaling molecule that promotes brain inflammation, was one of the first molecules that scientists found in higher levels in the brains of people with Alzheimers disease compared to healthy people. Its recognized as a critical player in bringing about much of the brain damage that follows a stroke and brain injury, so its no surprise that its presence in the brains of Alzheimers patients would be assumed to be part of the problem.

In the original development of his mouse, Shaftel worked closely with Stephanos Kyrkanides, D.D.S., Ph.D., associate professor in the Eastman Department of Dentistry and an expert on using a class of viruses known as lentiviruses for use in gene therapy. The team used a lentivirus to boost levels of IL-1 beta in select brain regions of its engineered mouse, then applied the technology in mice specially designed to develop Alzheimers disease.

The mice developed normally for six months. Then Shaftel raised the level of IL-1beta in one part of the brain the hippocampus, an area of the brain that specializes in memory and one of the first parts of the brain to be affected by the disease and followed the mice for an additional month, watching for effects in the brain regions that were awash in higher-than-normal levels of IL-1beta. Its the first use of an organism where scientists can boost IL-1beta in select areas and then watch what happens as the process unfolds.

The team expected to see the telltale clumps of material known as amyloid plaques, made up of the peptide amyloid beta, worsen. Instead, to the teams surprise, the brains of the mice with IL-1beta stuck in overdrive had only about half as many plaques as mice without the over-active IL-1beta.

Through extensive experiments, the team showed that the mice simply werent making fewer plaques, but rather that the body was better at getting rid of the plaques. T
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