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Bortezomib for salvage therapy against progressive myeloma

a, leucopenia, peripheral neuropathy and vasculitis) were observed in 7 patients, but no patient interrupted the treatment due to side effects.

The study indicates that the use of bortezomib, in this specific setting, is generally safe and may be effective in a relevant proportion of cases. The authors conclude that bortezomib alone may induce high quality responses as third line salvage therapy with acceptable toxicity in a significant proportion of homogeneously pre-treated myeloma patients with progressive disease after autologous transplantation and thalidomide.
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