Navigation Links
Bortezomib for salvage therapy against progressive myeloma

Despite the initial efficacy of these therapies against multiple myeloma (MM), relapse is invariably the rule. Bortezomib (Velcade, formerly PS-341, Millennium, USA) is a novel first-class agent that inhibits the proteasome, a // multicatalytic cellular enzyme whose activity entails several molecular mechanisms, including, in particular, the NF-kB pathway.

Currently, bortezomib, alone or in combination with dexamethasone and doxorubicin, is under investigation as first-line and maintenance therapy. However, previous studies on advanced disease included a mixture of patients with multiple and heterogeneous previous regimens. Therefore, in order to obtain more careful information about the efficacy and tolerability of this drug in more homogeneously and less heavily pre-treated patients, researchers from Italy focused on the effects of bortezomib on a selected cohort of MM patients who had progressive disease after previous treatments including exclusively AuSCT and thalidomide. They focused on the effects of bortezomib as third line treatment (second salvage therapy) in a very homogeneous group of MM patients induced by AuSCT and relapsed or refractory after thalidomide employed as second line treatment (first salvage therapy).

For the study to be published in the journal Leukemia Research (available online 18 August 2005), twenty-one patients with multiple myeloma, all relapsed after frontline autologous stem cell transplantation and all relapsed again after or resistant to thalidomide (employed as second line treatment) received bortezomib without adjunct of steroids as third line therapy. Three patients died of progressive disease during the first 2 cycles with bortezomib. Eighteen patients received at least 2 cycles and were evaluated for response. According to EBMT criteria, 2 complete (negative immunofixation) and 7 partial remissions were achieved. Duration of response lasted from 2 to 14+ months. Grades 3?4 toxicities (thrombocytopeni
'"/>




Page: 1 2

Related medicine news :

1. Acupuncture May Help Chemotherapy Side Effects
2. Antioxidants protect health tissue in people undergoing radiation therapy.
3. Distraction therapy found very effective in postoperative patients
4. Acupuncture superseeds massage therapy for short term relief of pain
5. Ovarian cancer in relationship with Hormone therapy
6. New therapy better at increasing bone density
7. Gene therapy - Aim to improve blood flow
8. Gene therapy restores sight
9. Heat therapy relieves back pain
10. Radiotherapy helps in colon cancer
11. New therapy for pimples
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Bortezomib for salvage therapy against progressive myeloma

(Date:10/20/2014)... 2014 National Teen Driver Safety Week is ... Academy of Pediatrics (Ohio AAP, http://www.ohioaap.org ) is joining ... of teen drivers to talk to their teens and always ... vehicle crashes are the leading cause of death for U.S. ... fatal crashes, and 859 (42%) of those teen drivers were ...
(Date:10/20/2014)... Punzoné , the first line of ultra-premium ... lot to celebrate this month. October marks Italian Heritage Month ... contributions of Americans of Italian heritage and Italians in America. ... shares its favorite Italian cocktails and encourages everyone to enjoy ... if it is only in a glass. , Punzoné ...
(Date:10/19/2014)... 20, 2014 The leading review ... http://www.top10bestseohosting.com/go/iPage/ ) and GreenGeeks are the best Dedicated ... for those who want to buy high quality ... , The IT manager of Top10BestSEOHosting.com says, “We ... recommended suppliers for everyone. A lot of the ...
(Date:10/19/2014)... 2014 Having been working in the garment ... of customer needs. According to James, one of the company’s ... sequins, or with high-low skirts that add beauty to them. ... Recently, LunaDress has unveiled its new selection of 2014 long ... company’s brand new items are available in over 20 popular ...
(Date:10/19/2014)... NC (PRWEB) October 19, 2014 ... building program has just been released to the ... the online body building and fitness community. The ... attention of DietsAndFitnessGuides.com's Vin Delmonico prompting an investigative ... experience of hitting what is commonly known as ...
Breaking Medicine News(10 mins):Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2Health News:Visual Impact Frequency Training Review: Rusty Moore's Latest Fitness Guide Released 2
... at the Washington Hospital Center studied the use of ... blocked arteries. // ,These blocked arteries are ... as it leads to devastating complications such as amputation. ... high blood pressure are at high risk for losing ...
... grant for the South African AIDS program from the existing ... current financial year (2006- 07). //Finance Minister Trevor Manuel, who ... proposal. ,The minister also said that care of ... priority of the African Government. The year 2006 has even ...
... South Korean firm LG Electronics has said that it will ... with a filter made from using an enzyme contained in ... confer protection against the dreaded bird flu virus. ... against bird flu," LG spokeswoman Park Se-won said. The filter ...
... A nationwide survey conducted among Americans has revealed that ... sex to a mere chance. The results of the ... where concerns about sex selection may be prevalent, leading ... found that only eight percent of people would use ...
... health court, the first one of its kind in the ... motive to pick // out sober and non violent defendants, ... in the jails. ,U.S. House Speaker Dennis Hastert ... Kane County Treatment Alternative Court. ,Kane Chief Judge Donald ...
... of the Union address encouraged Americans to open health savings ... the nation's out-of-control medical costs. It was // ... that HSAs are the means by which the doctors cure ... client leader in Houston for Hewitt Associates said that HSA ...
Cached Medicine News:Health News:Laser Used To Clear Blocked Arteries Preventing Amputation, 2Health News:Americans Not Interested In Choosing Sex Of Child: Survey 2Health News:President Bush proposes HSAs scheme for the benefit of both the workers and the country 2Health News:President Bush proposes HSAs scheme for the benefit of both the workers and the country 3
(Date:10/17/2014)... Calif. , Oct. 17, 2014 A victim ... Orange County doctor with a history of alcohol ... ad for Yes on Prop 46 today, highlighting how Prop ... drug and alcohol testing. The ad pictures ... off reading "911-Report To ER."  Proposition 46 will enact the ...
(Date:10/17/2014)... Oct. 17, 2014 The following is ... Policy: The Green Park Collaborative (GPC) ... and private payers, medical device and pharmaceutical companies, ... experts January 12, 2015 at its first ever ... weight loss treatments.  Participants will discuss study designs ...
(Date:10/17/2014)... , Oct. 17, 2014  UBM Medica US announces ... for endocrinologists and other clinicians who treat patients with ... on effective use of insulin .  ... insulin replacement therapy – daily injections of ... progressive decline in the function of pancreatic beta cells. ...
Breaking Medicine Technology:Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 2Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 4Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 3
... today that it will partner with Direct Relief USA ... shots to community clinic and health center patients who ... organization that works with 1,100 clinics and health centers ... and supplies for their low-income and uninsured patients.  Most ...
... Colo., Sept. 8 N30 Pharmaceuticals, LLC today announced ... a first-in-class inhibitor of s-nitrosoglutathione reductase (GSNOR). ... administered to human beings. N6022 has the potential to ... human diseases, such as asthma, chronic obstructive pulmonary disease ...
Cached Medicine Technology:CVS Caremark to Offer $5 Million in Free Flu Shots to Uninsured Patients of Community Clinics and Health Centers Beginning September 20 2CVS Caremark to Offer $5 Million in Free Flu Shots to Uninsured Patients of Community Clinics and Health Centers Beginning September 20 3CVS Caremark to Offer $5 Million in Free Flu Shots to Uninsured Patients of Community Clinics and Health Centers Beginning September 20 4N30 Pharma Initiates Phase 1 Trials of Novel Reductase Inhibitor 2
Indications For Usage: ,Single patient use on anesthetized patients and respiratory care patients who require a breathing circuit. The product is intended to be replaced at least once every 24 hours....
... Portex® Thermovent® T helps provide protection to the ... small and extremely lightweight making it ideal for ... a high rate of heat and moisture recovery, ... ,All HMEs and filters have ISO standard ...
This adjustable-volume digital micropipet is used to accurately measure and transfer small solution volumes in the 20-200 microliter range....
... The AlphaPette Pipettor is the #1 ... Offers accuracy, comfort, and reliability. Continuously ... volume readout sub-micrometer. Easy interchangeable ejector ... tiny hands. Adjustable rapid pipet tip ...
Medicine Products: