( fect bone turnover in children with can...)Bone Fragility, a Risk for Children With Cancer,Health

fect bone turnover in children with cancer. First, patients with cancer are less physically active. Second, chemotherapy and cranial radiotherapy are linked to decreased bone formation and abnormally low BMD.

This low BMD may persist for years after treatment and is associated with symptoms, which can be as benign as bone pain or as severe as fractures. The authors report that the risk of fractures in children with low BMD significantly increases several fold.

However, several treatments are available to stimulate mineralization and minimize the loss at such a critical bone development stage. These include physical exercise and dietary modification programs as well as drug treatment with a class of drugs used to treat osteoporosis in post-menopausal women called bisphosphonates.

Drs. Sala and Barr conclude that "loss of bone mineral is clearly a common consequence of the treatment of cancer in children and adolescents, fitting the paradigm of chronic disease often attended by therapy." This requires, the authors add, "recognition that osteopenia in children with cancer is of multi-factorial origin requiring comprehensive strategies for amelioration and prevention."

Source-Eurekalert
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